Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions

Aim and purpose: To investigate the difference in biological behavior between Giant Cell Lesion in oral cavity with Giant Cells tumors in long bones by using transforming growth factor beta (IHC) marker. Materials and method: Total of 40 cases of giant cell lesions (C.G.C.G., P.G.C.G. and G.C.T) w...

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Main Authors:	Abdul Jabbar, Omar, Mustafa Al-Ahmad, Basma Ezzat, Faisal, Ghasak Ghazi
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/45156/ http://irep.iium.edu.my/45156/ http://irep.iium.edu.my/45156/1/2015-International_Dental_Journal_%28my_abstract_in_page_31%29.pdf

id	iium-45156
recordtype	eprints
spelling	iium-451562016-05-23T03:32:17Z http://irep.iium.edu.my/45156/ Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions Abdul Jabbar, Omar Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi RK Dentistry Aim and purpose: To investigate the difference in biological behavior between Giant Cell Lesion in oral cavity with Giant Cells tumors in long bones by using transforming growth factor beta (IHC) marker. Materials and method: Total of 40 cases of giant cell lesions (C.G.C.G., P.G.C.G. and G.C.T) were included in this study. 17 cases were of G.C.T, 14 of C.G.C.G. and 9 cases were of P.G.C.G. Immunohistochemical staining technique by TGF-b marker was conducted upon these cases showing positive expression in both multinucleated giant cells (MGC) and mononucleated stromal cells (MC) which are considered to be the main histopathological constituent of giant cell lesions.Results: The PGCL showed lightly higher expression of TGF B1 in (MC) than CGCL and GCT but with a non-significant difference value. In comparison of PGCL and CGCL with GCT, they showed higher expression of TGF-b in MGC (p < 0.05). Summary and conclusions: Our results suggest that, in CGCL and PCGL the TGF-b may be important for osteoclastogenesis and bone resorption. 2015 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/45156/1/2015-International_Dental_Journal_%28my_abstract_in_page_31%29.pdf Abdul Jabbar, Omar and Mustafa Al-Ahmad, Basma Ezzat and Faisal, Ghasak Ghazi (2015) Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions. In: FDI 2015 - Annual World Dental Congress, 22-25 Sep 2015, Bangkok. http://onlinelibrary.wiley.com/doi/10.1111/idj.12194/abstract
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RK Dentistry
spellingShingle	RK Dentistry Abdul Jabbar, Omar Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
description	Aim and purpose: To investigate the difference in biological behavior between Giant Cell Lesion in oral cavity with Giant Cells tumors in long bones by using transforming growth factor beta (IHC) marker. Materials and method: Total of 40 cases of giant cell lesions (C.G.C.G., P.G.C.G. and G.C.T) were included in this study. 17 cases were of G.C.T, 14 of C.G.C.G. and 9 cases were of P.G.C.G. Immunohistochemical staining technique by TGF-b marker was conducted upon these cases showing positive expression in both multinucleated giant cells (MGC) and mononucleated stromal cells (MC) which are considered to be the main histopathological constituent of giant cell lesions.Results: The PGCL showed lightly higher expression of TGF B1 in (MC) than CGCL and GCT but with a non-significant difference value. In comparison of PGCL and CGCL with GCT, they showed higher expression of TGF-b in MGC (p < 0.05). Summary and conclusions: Our results suggest that, in CGCL and PCGL the TGF-b may be important for osteoclastogenesis and bone resorption.
format	Conference or Workshop Item
author	Abdul Jabbar, Omar Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi
author_facet	Abdul Jabbar, Omar Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi
author_sort	Abdul Jabbar, Omar
title	Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_short	Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_full	Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_fullStr	Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_full_unstemmed	Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_sort	immunoexpression of tgf-b in giant cell tumour, central and peripheral giant cell lesions
publishDate	2015
url	http://irep.iium.edu.my/45156/ http://irep.iium.edu.my/45156/ http://irep.iium.edu.my/45156/1/2015-International_Dental_Journal_%28my_abstract_in_page_31%29.pdf
first_indexed	2023-09-18T21:04:17Z
last_indexed	2023-09-18T21:04:17Z
_version_	1777410828946898944

Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions

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