Evaluation of the skin penetration behaviour of sunscreen actives

INTRODUCTION The effectiveness of sunscreens depends on the absorption characteristics of each single UV filter substance. The objective of this study was to determine the penetration profile of UV filter substances using the imaging technique of DermaLab Combo probe and analytical technique of U...

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Main Authors:	Ab. Hadi, Hazrina, Awadh, Ammar Ihsan Jawad
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/45043/ http://irep.iium.edu.my/45043/1/45043.pdf

id	iium-45043
recordtype	eprints
spelling	iium-450432015-11-27T06:51:25Z http://irep.iium.edu.my/45043/ Evaluation of the skin penetration behaviour of sunscreen actives Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad RS Pharmacy and materia medica INTRODUCTION The effectiveness of sunscreens depends on the absorption characteristics of each single UV filter substance. The objective of this study was to determine the penetration profile of UV filter substances using the imaging technique of DermaLab Combo probe and analytical technique of UV/VIS Spectroscopy. MATERIALS AND METHODS 2 mg/cm2 of sunscreen lotion brand Banana Boat SPF 50 PA +++ on of the flexor arms of 10 volunteers. Tape stripping was conducted 30 minutes after the application. After one minute, the strip was then peeled. The videoscope image was taken after each tape strip until 8 tape strips. RESULTS AND DISCUSSION Both results obtained with UV/VIS spectroscopy and videoscope indicate the 1st tape strip contains high concentration of UV-A and UV-B filter compounds. This shows that the removed tape strips consist of the amount of stratum corneum as well as the topically applied substances that are transferred to the tape [1]. The 2nd tape strip has small concentration of topically applied substances of UV-B filters that can relate to less sunscreen distributed within a marked skin area. 3rd tape showed to have lower absorbance value detected and less sunscreen distribution on the skin after tape stripping. There is no significant absorbance detected and measured by UV/VIS spectrophotometer for the fourth until eighth tape strips although there is sunscreen distribution on a marked skin surface. The absorbance of topically applied substances might be reduced if the substances do not distributed homogenously [2]. The data of sunscreen distribution and the absorbance reading are shown in Fig. 1 and Fig. 2, respectively. Fig. 1. Videoscope observation on the distribution of sunscreen on the skin before and after the tape stripping using DermaLab Combo 2015 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/45043/1/45043.pdf Ab. Hadi, Hazrina and Awadh, Ammar Ihsan Jawad (2015) Evaluation of the skin penetration behaviour of sunscreen actives. In: The 6th APS International PharmSci 2015, 7th-9th Sept. 2015, East Midlands Conference Centre, Nottingham. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad Evaluation of the skin penetration behaviour of sunscreen actives
description	INTRODUCTION The effectiveness of sunscreens depends on the absorption characteristics of each single UV filter substance. The objective of this study was to determine the penetration profile of UV filter substances using the imaging technique of DermaLab Combo probe and analytical technique of UV/VIS Spectroscopy. MATERIALS AND METHODS 2 mg/cm2 of sunscreen lotion brand Banana Boat SPF 50 PA +++ on of the flexor arms of 10 volunteers. Tape stripping was conducted 30 minutes after the application. After one minute, the strip was then peeled. The videoscope image was taken after each tape strip until 8 tape strips. RESULTS AND DISCUSSION Both results obtained with UV/VIS spectroscopy and videoscope indicate the 1st tape strip contains high concentration of UV-A and UV-B filter compounds. This shows that the removed tape strips consist of the amount of stratum corneum as well as the topically applied substances that are transferred to the tape [1]. The 2nd tape strip has small concentration of topically applied substances of UV-B filters that can relate to less sunscreen distributed within a marked skin area. 3rd tape showed to have lower absorbance value detected and less sunscreen distribution on the skin after tape stripping. There is no significant absorbance detected and measured by UV/VIS spectrophotometer for the fourth until eighth tape strips although there is sunscreen distribution on a marked skin surface. The absorbance of topically applied substances might be reduced if the substances do not distributed homogenously [2]. The data of sunscreen distribution and the absorbance reading are shown in Fig. 1 and Fig. 2, respectively. Fig. 1. Videoscope observation on the distribution of sunscreen on the skin before and after the tape stripping using DermaLab Combo
format	Conference or Workshop Item
author	Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad
author_facet	Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad
author_sort	Ab. Hadi, Hazrina
title	Evaluation of the skin penetration behaviour of sunscreen actives
title_short	Evaluation of the skin penetration behaviour of sunscreen actives
title_full	Evaluation of the skin penetration behaviour of sunscreen actives
title_fullStr	Evaluation of the skin penetration behaviour of sunscreen actives
title_full_unstemmed	Evaluation of the skin penetration behaviour of sunscreen actives
title_sort	evaluation of the skin penetration behaviour of sunscreen actives
publishDate	2015
url	http://irep.iium.edu.my/45043/ http://irep.iium.edu.my/45043/1/45043.pdf
first_indexed	2023-09-18T21:04:04Z
last_indexed	2023-09-18T21:04:04Z
_version_	1777410815230476288

Evaluation of the skin penetration behaviour of sunscreen actives

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