$Retinal vasculature fractal dimension measures vessel density$

Retinal vasculature fractal dimension measures vessel density

Purpose: The goal of this study was to provide the empirical evidence of fractal dimension as an indirect measure of retinal vasculature density. Materials and methods: Two hundred retinal samples of right eye [57.0% females (n = 114) and 43.0% males (n = 86)] were selected from baseline visit. A...

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Main Authors:	Ab Hamid, Fadilah, Che Azemin, Mohd Zulfaezal, Salam, Adzura, Aminuddin, Amilia, Mohd Daud, Norsyazwani, Zahari, Ilyanoon
Format:	Article
Language:	English English English English
Published:	Taylor and Francis Ltd 2016
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/45020/ http://irep.iium.edu.my/45020/ http://irep.iium.edu.my/45020/ http://irep.iium.edu.my/45020/1/current_eye_research.pdf http://irep.iium.edu.my/45020/4/45020_Retinal%20Vasculature%20Fractal.pdf http://irep.iium.edu.my/45020/5/45020_Retinal%20Vasculature%20Fractal_WOS.pdf http://irep.iium.edu.my/45020/6/45020_Retinal%20Vasculature%20Fractal_SCOPUS.pdf

id	iium-45020
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spelling	iium-450202017-04-12T04:03:52Z http://irep.iium.edu.my/45020/ Retinal vasculature fractal dimension measures vessel density Ab Hamid, Fadilah Che Azemin, Mohd Zulfaezal Salam, Adzura Aminuddin, Amilia Mohd Daud, Norsyazwani Zahari, Ilyanoon RE Ophthalmology Purpose: The goal of this study was to provide the empirical evidence of fractal dimension as an indirect measure of retinal vasculature density. Materials and methods: Two hundred retinal samples of right eye [57.0% females (n = 114) and 43.0% males (n = 86)] were selected from baseline visit. A custom-written software was used for vessel segmentation. Vessel segmentation is the process of transforming two-dimensional color images into binary images (i.e. black and white pixels). The circular area of approximately 2.6 optic disc radii surrounding the center of optic disc was cropped. The non-vessels fragments were removed. FracLac was used to measure the fractal dimension and vessel density of retinal vessels. Results: This study suggested that 14.1% of the region of interest (i.e. approximately 2.6 optic disk radii) comprised retinal vessel structure. Using correlation analysis, vessel density measurement and fractal dimension estimation are linearly and strongly correlated (R = 0.942, R2 = 0.89, p50.001). Polynomial regression model suggests quadratic regression as the best fit for our data (linear: R2 = 0.1024, 198 d.f., p50.001, quadratic: R2 = 0.1236, 197 d.f., p50.001, cubic: R2 = 0.1236, 196 d.f., p50.001). Conclusions: This study demonstrated the ability of vessel density measurement to detect the changes in the morphology of retinal microvascular associated with increasing age. Thus, vessel density can be suggested to be another parameter in the quantification of retinal microvasculature Taylor and Francis Ltd 2016-06-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45020/1/current_eye_research.pdf application/pdf en http://irep.iium.edu.my/45020/4/45020_Retinal%20Vasculature%20Fractal.pdf application/pdf en http://irep.iium.edu.my/45020/5/45020_Retinal%20Vasculature%20Fractal_WOS.pdf application/pdf en http://irep.iium.edu.my/45020/6/45020_Retinal%20Vasculature%20Fractal_SCOPUS.pdf Ab Hamid, Fadilah and Che Azemin, Mohd Zulfaezal and Salam, Adzura and Aminuddin, Amilia and Mohd Daud, Norsyazwani and Zahari, Ilyanoon (2016) Retinal vasculature fractal dimension measures vessel density. Current Eye Research, 41 (6). pp. 823-831. ISSN 0271-3683 E-ISSN 1460-2202 http://dx.doi.org/10.3109/02713683.2015.1056375 10.3109/02713683.2015.1056375
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Ab Hamid, Fadilah Che Azemin, Mohd Zulfaezal Salam, Adzura Aminuddin, Amilia Mohd Daud, Norsyazwani Zahari, Ilyanoon Retinal vasculature fractal dimension measures vessel density
description	Purpose: The goal of this study was to provide the empirical evidence of fractal dimension as an indirect measure of retinal vasculature density. Materials and methods: Two hundred retinal samples of right eye [57.0% females (n = 114) and 43.0% males (n = 86)] were selected from baseline visit. A custom-written software was used for vessel segmentation. Vessel segmentation is the process of transforming two-dimensional color images into binary images (i.e. black and white pixels). The circular area of approximately 2.6 optic disc radii surrounding the center of optic disc was cropped. The non-vessels fragments were removed. FracLac was used to measure the fractal dimension and vessel density of retinal vessels. Results: This study suggested that 14.1% of the region of interest (i.e. approximately 2.6 optic disk radii) comprised retinal vessel structure. Using correlation analysis, vessel density measurement and fractal dimension estimation are linearly and strongly correlated (R = 0.942, R2 = 0.89, p50.001). Polynomial regression model suggests quadratic regression as the best fit for our data (linear: R2 = 0.1024, 198 d.f., p50.001, quadratic: R2 = 0.1236, 197 d.f., p50.001, cubic: R2 = 0.1236, 196 d.f., p50.001). Conclusions: This study demonstrated the ability of vessel density measurement to detect the changes in the morphology of retinal microvascular associated with increasing age. Thus, vessel density can be suggested to be another parameter in the quantification of retinal microvasculature
format	Article
author	Ab Hamid, Fadilah Che Azemin, Mohd Zulfaezal Salam, Adzura Aminuddin, Amilia Mohd Daud, Norsyazwani Zahari, Ilyanoon
author_facet	Ab Hamid, Fadilah Che Azemin, Mohd Zulfaezal Salam, Adzura Aminuddin, Amilia Mohd Daud, Norsyazwani Zahari, Ilyanoon
author_sort	Ab Hamid, Fadilah
title	Retinal vasculature fractal dimension measures vessel density
title_short	Retinal vasculature fractal dimension measures vessel density
title_full	Retinal vasculature fractal dimension measures vessel density
title_fullStr	Retinal vasculature fractal dimension measures vessel density
title_full_unstemmed	Retinal vasculature fractal dimension measures vessel density
title_sort	retinal vasculature fractal dimension measures vessel density
publisher	Taylor and Francis Ltd
publishDate	2016
url	http://irep.iium.edu.my/45020/ http://irep.iium.edu.my/45020/ http://irep.iium.edu.my/45020/ http://irep.iium.edu.my/45020/1/current_eye_research.pdf http://irep.iium.edu.my/45020/4/45020_Retinal%20Vasculature%20Fractal.pdf http://irep.iium.edu.my/45020/5/45020_Retinal%20Vasculature%20Fractal_WOS.pdf http://irep.iium.edu.my/45020/6/45020_Retinal%20Vasculature%20Fractal_SCOPUS.pdf
first_indexed	2023-09-18T21:04:02Z
last_indexed	2023-09-18T21:04:02Z
_version_	1777410813158490112

Retinal vasculature fractal dimension measures vessel density

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