Diffusion of betamethasone 17-Valerate from palm olein-based vehicle

The current study aims to produce pharmaceutical formulation using palm olein as the oil phase with betamethasone 17-valerate as the active ingredient and to compare efficacy with that of commercial products. Creams were prepared using Span® 20 and Tween® 20 as surfactants, Carbopol® 940 as thickene...

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Main Authors:	Win, Thazin, Ahmad, Kausar, Md. Jaffri, Juliana, Edueng, Khadijah
Format:	Conference or Workshop Item
Language:	English
Published:	2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/44989/ http://irep.iium.edu.my/44989/1/Symposium_CRDDS2014_DiffusionBetamethasone_kausar20151007.pdf

id	iium-44989
recordtype	eprints
spelling	iium-449892015-11-19T01:49:53Z http://irep.iium.edu.my/44989/ Diffusion of betamethasone 17-Valerate from palm olein-based vehicle Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah RS Pharmacy and materia medica The current study aims to produce pharmaceutical formulation using palm olein as the oil phase with betamethasone 17-valerate as the active ingredient and to compare efficacy with that of commercial products. Creams were prepared using Span® 20 and Tween® 20 as surfactants, Carbopol® 940 as thickener, methyl paraben, propyl paraben and chlorocresol as preservatives, propylene glycol as solubilizer and distilled water as aqueous phase. The formulations were characterized, subjected to stability studies for 3 months and degradation of betamethasone 17-valerate in the formulations was analysed using HPLC. Evaluation on drug release with three different viscosities was further performed with Hanson Verticle Diffusion Cell System using cellulose acetate and rat skin as membranes and the samples were quantified with HPLC. The results were compared to that of three commmercially available products. The optimized formulation showed particle size ranging from 3 to 14 µm, viscosity 68.2±1.43 mPa.s, yield stress 36.5± 0.2 Pa, thixotropy 647± 58, pH 5.8± 0.1 and zeta potential -51 ± 11 mV. The creams exhibited pseudoplastic behaviour and found to be thixotropic. Less than 5 % of drug is degraded during the 3-month period when subjected to 3 different temperatures. The drug release rates from palm-olein-in-water emulsions were 4.5 times higher than that of commercial products. In conclusion, these findings proved that the creams produced from palm-olein-in-water emulsion could be a superior alternative vehicle for topical drug delivery system. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/44989/1/Symposium_CRDDS2014_DiffusionBetamethasone_kausar20151007.pdf Win, Thazin and Ahmad, Kausar and Md. Jaffri, Juliana and Edueng, Khadijah (2014) Diffusion of betamethasone 17-Valerate from palm olein-based vehicle. In: CRDDS2014, Controlled Release & Drug Delivery Symposium 2014, 23rd-24th Mar. 2014, DK2 & DK3, Universiti Kebangsaan Malaysia Kuala Lumpur Kampus.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
description	The current study aims to produce pharmaceutical formulation using palm olein as the oil phase with betamethasone 17-valerate as the active ingredient and to compare efficacy with that of commercial products. Creams were prepared using Span® 20 and Tween® 20 as surfactants, Carbopol® 940 as thickener, methyl paraben, propyl paraben and chlorocresol as preservatives, propylene glycol as solubilizer and distilled water as aqueous phase. The formulations were characterized, subjected to stability studies for 3 months and degradation of betamethasone 17-valerate in the formulations was analysed using HPLC. Evaluation on drug release with three different viscosities was further performed with Hanson Verticle Diffusion Cell System using cellulose acetate and rat skin as membranes and the samples were quantified with HPLC. The results were compared to that of three commmercially available products. The optimized formulation showed particle size ranging from 3 to 14 µm, viscosity 68.2±1.43 mPa.s, yield stress 36.5± 0.2 Pa, thixotropy 647± 58, pH 5.8± 0.1 and zeta potential -51 ± 11 mV. The creams exhibited pseudoplastic behaviour and found to be thixotropic. Less than 5 % of drug is degraded during the 3-month period when subjected to 3 different temperatures. The drug release rates from palm-olein-in-water emulsions were 4.5 times higher than that of commercial products. In conclusion, these findings proved that the creams produced from palm-olein-in-water emulsion could be a superior alternative vehicle for topical drug delivery system.
format	Conference or Workshop Item
author	Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah
author_facet	Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah
author_sort	Win, Thazin
title	Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_short	Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_full	Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_fullStr	Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_full_unstemmed	Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_sort	diffusion of betamethasone 17-valerate from palm olein-based vehicle
publishDate	2014
url	http://irep.iium.edu.my/44989/ http://irep.iium.edu.my/44989/1/Symposium_CRDDS2014_DiffusionBetamethasone_kausar20151007.pdf
first_indexed	2023-09-18T21:03:59Z
last_indexed	2023-09-18T21:03:59Z
_version_	1777410809932021760

Diffusion of betamethasone 17-Valerate from palm olein-based vehicle

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