Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis

Background: Osteoarthritis (OA) is a common form of arthritis that affects major joint structures including the subchondral bone plate (Sbp) and trabecular bone (Tb). Previous studies have shown that the patterns of subchondral bone (Sb) changes in the medial and lateral sides of tibial epiphysis, i...

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Main Authors:	Ahmad Rafani, Fikri, Mohammad Subri, Abdul Hadi, Mohd Sabri, Muhammad Farhan, Robson Brown, Kate, Sharif, Mohammed, Zamli , Zaitunnatakhin
Format:	Article
Language:	English English
Published:	Universiti Putra Malaysia 2015
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/44631/ http://irep.iium.edu.my/44631/1/IABS-2015-poster_Zaitunnatakhin_Zamli.pdf http://irep.iium.edu.my/44631/4/IABS_2015.pdf

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spelling	iium-446312018-12-20T04:36:50Z http://irep.iium.edu.my/44631/ Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis Ahmad Rafani, Fikri Mohammad Subri, Abdul Hadi Mohd Sabri, Muhammad Farhan Robson Brown, Kate Sharif, Mohammed Zamli , Zaitunnatakhin R Medicine (General) Background: Osteoarthritis (OA) is a common form of arthritis that affects major joint structures including the subchondral bone plate (Sbp) and trabecular bone (Tb). Previous studies have shown that the patterns of subchondral bone (Sb) changes in the medial and lateral sides of tibial epiphysis, in both human and animal models of OA are different. The aim of the current study is to investigate detailed structural changes of Sbp and Tb in sub-regions within each side of the tibia during the initiation and progression of OA in Dunkin Hartley (DH) which develop OA around 12 weeks of age and Bristol Strains 2 (BS2) guinea pigs that develop OA around 24 weeks. Methods: The micro-computed tomography (Micro-CT) images of the proximal part of the right tibia of six males DH (n=24) and BS2 (n=24) guinea pigs were obtained from previous study, and collected at 10, 16, 24, and 30 weeks of age. Micro-CT analyzer software was used to quantify the Sbp thickness (SbpTh); Tb morphometric and bone mineral density (BMD) in four sub-regions (i.e. anteromedial, anterolateral, posteromedial, and posterolateral) within each side of the tibial epiphysis. The data were then compared between anterior and posterior sub-regions, the medial and lateral sub-regions, and time points. Results: Sb changes in the four sub-regions were generally more prominent in the medial than lateral side, and in the DH than BS2. In the medial side of the tibia, the posteromedial or PMM sub-region of DH showed a significantly greater of SbpTh [PMM: 463.43 Universiti Putra Malaysia 2015-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44631/1/IABS-2015-poster_Zaitunnatakhin_Zamli.pdf application/pdf en http://irep.iium.edu.my/44631/4/IABS_2015.pdf Ahmad Rafani, Fikri and Mohammad Subri, Abdul Hadi and Mohd Sabri, Muhammad Farhan and Robson Brown, Kate and Sharif, Mohammed and Zamli , Zaitunnatakhin (2015) Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis. The Malaysian Journal of Microscopy, 11 (supp.1). p. 46. ISSN 1823-7010
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Ahmad Rafani, Fikri Mohammad Subri, Abdul Hadi Mohd Sabri, Muhammad Farhan Robson Brown, Kate Sharif, Mohammed Zamli , Zaitunnatakhin Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis
description	Background: Osteoarthritis (OA) is a common form of arthritis that affects major joint structures including the subchondral bone plate (Sbp) and trabecular bone (Tb). Previous studies have shown that the patterns of subchondral bone (Sb) changes in the medial and lateral sides of tibial epiphysis, in both human and animal models of OA are different. The aim of the current study is to investigate detailed structural changes of Sbp and Tb in sub-regions within each side of the tibia during the initiation and progression of OA in Dunkin Hartley (DH) which develop OA around 12 weeks of age and Bristol Strains 2 (BS2) guinea pigs that develop OA around 24 weeks. Methods: The micro-computed tomography (Micro-CT) images of the proximal part of the right tibia of six males DH (n=24) and BS2 (n=24) guinea pigs were obtained from previous study, and collected at 10, 16, 24, and 30 weeks of age. Micro-CT analyzer software was used to quantify the Sbp thickness (SbpTh); Tb morphometric and bone mineral density (BMD) in four sub-regions (i.e. anteromedial, anterolateral, posteromedial, and posterolateral) within each side of the tibial epiphysis. The data were then compared between anterior and posterior sub-regions, the medial and lateral sub-regions, and time points. Results: Sb changes in the four sub-regions were generally more prominent in the medial than lateral side, and in the DH than BS2. In the medial side of the tibia, the posteromedial or PMM sub-region of DH showed a significantly greater of SbpTh [PMM: 463.43
format	Article
author	Ahmad Rafani, Fikri Mohammad Subri, Abdul Hadi Mohd Sabri, Muhammad Farhan Robson Brown, Kate Sharif, Mohammed Zamli , Zaitunnatakhin
author_facet	Ahmad Rafani, Fikri Mohammad Subri, Abdul Hadi Mohd Sabri, Muhammad Farhan Robson Brown, Kate Sharif, Mohammed Zamli , Zaitunnatakhin
author_sort	Ahmad Rafani, Fikri
title	Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis
title_short	Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis
title_full	Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis
title_fullStr	Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis
title_full_unstemmed	Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis
title_sort	temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis
publisher	Universiti Putra Malaysia
publishDate	2015
url	http://irep.iium.edu.my/44631/ http://irep.iium.edu.my/44631/1/IABS-2015-poster_Zaitunnatakhin_Zamli.pdf http://irep.iium.edu.my/44631/4/IABS_2015.pdf
first_indexed	2023-09-18T21:03:26Z
last_indexed	2023-09-18T21:03:26Z
_version_	1777410775385636864

Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis

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