Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics

Cosmos caudatus (“Ulam Raja” in Malaysia) is a plant used in Malaysia to enhance vitality and has been studied for its antidiabetic activity. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted...

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Main Authors:	Khatib, Alfi, Javadi, Neda, Abas, Faridah, Abdul Hamid, Azizah, Simoh, Sanimah, Shaari, Khozirah, Ismail, Intan Safinar, Mediani, Ahmed
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/44594/ http://irep.iium.edu.my/44594/ http://irep.iium.edu.my/44594/1/44594.pdf

id	iium-44594
recordtype	eprints
spelling	iium-445942016-08-10T03:56:52Z http://irep.iium.edu.my/44594/ Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Q Science (General) Cosmos caudatus (“Ulam Raja” in Malaysia) is a plant used in Malaysia to enhance vitality and has been studied for its antidiabetic activity. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol were employed. Gas chromatography-mass spectrometry (GC-MS) and multivariate data analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained loading scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different quality of samples. GCMS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. Through this approach several chemical makers e.g. catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified as an α-glucosidase inhibitors of this herb. 2015-08-24 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/44594/1/44594.pdf Khatib, Alfi and Javadi, Neda and Abas, Faridah and Abdul Hamid, Azizah and Simoh, Sanimah and Shaari, Khozirah and Ismail, Intan Safinar and Mediani, Ahmed (2015) Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics. In: 29th Scientific Meeting of Malaysian Society of Pharmacology and Physiolgy (MSPP), 24-25 August 2015, Setia City Convention Centre, Shah Alam, Malaysia. (Unpublished) http://medicine.uitm.edu.my/mspp2015/index.php/scientific-program/free-oral-communications-session-1
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
description	Cosmos caudatus (“Ulam Raja” in Malaysia) is a plant used in Malaysia to enhance vitality and has been studied for its antidiabetic activity. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol were employed. Gas chromatography-mass spectrometry (GC-MS) and multivariate data analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained loading scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different quality of samples. GCMS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. Through this approach several chemical makers e.g. catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified as an α-glucosidase inhibitors of this herb.
format	Conference or Workshop Item
author	Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed
author_facet	Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed
author_sort	Khatib, Alfi
title	Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
title_short	Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
title_full	Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
title_fullStr	Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
title_full_unstemmed	Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
title_sort	identification of alpha-glucosidase inhibitors in cosmos caudatus leaves using gc-ms based metabolomics
publishDate	2015
url	http://irep.iium.edu.my/44594/ http://irep.iium.edu.my/44594/ http://irep.iium.edu.my/44594/1/44594.pdf
first_indexed	2023-09-18T21:03:23Z
last_indexed	2023-09-18T21:03:23Z
_version_	1777410772472692736

Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics

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