Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats
Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer's disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid ar...
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Elsevier
2015
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iium-445742017-11-15T00:47:03Z http://irep.iium.edu.my/44574/ Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats Saxena, Anil Kumar Abdul Majeed, Saif Saad Gurtu, Sunil Mohamed, Wael M. Y. R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer's disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms, which is thought to play a significant role in chronic degenerative neurological disorders, the present study was planned to assess the ROS status by measuring the levels of anti-oxidant enzymes that might occur during chronic cerebral hypoperfusion. Antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue at eight weeks of 2VO induction in rats. Results show significantly elevated levels of GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occurs in response to increased oxidative stress following ischemic insult. Elsevier 2015-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44574/1/Publication-Anil.pdf application/pdf en http://irep.iium.edu.my/44574/4/44574_Investigation%20of%20redox%20status%20in%20chronic%20cerebral%20hypoperfusion-induced%20neurodegeneration%20in%20rats_SCOPUS.pdf Saxena, Anil Kumar and Abdul Majeed, Saif Saad and Gurtu, Sunil and Mohamed, Wael M. Y. (2015) Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats. Applied & Translational Genomics, 5 (1). pp. 30-32. ISSN 2212-0661 http://www.sciencedirect.com/science/article/pii/S2212066115300089 10.1016/j.atg.2015.05.004 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease |
| spellingShingle |
R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease Saxena, Anil Kumar Abdul Majeed, Saif Saad Gurtu, Sunil Mohamed, Wael M. Y. Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| description |
Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer's disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms, which is thought to play a significant role in chronic degenerative neurological disorders, the present study was planned to assess the ROS status by measuring the levels of anti-oxidant enzymes that might occur during chronic cerebral hypoperfusion. Antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue at eight weeks of 2VO induction in rats. Results show significantly elevated levels of GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occurs in response to increased oxidative stress following ischemic insult. |
| format |
Article |
| author |
Saxena, Anil Kumar Abdul Majeed, Saif Saad Gurtu, Sunil Mohamed, Wael M. Y. |
| author_facet |
Saxena, Anil Kumar Abdul Majeed, Saif Saad Gurtu, Sunil Mohamed, Wael M. Y. |
| author_sort |
Saxena, Anil Kumar |
| title |
Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_short |
Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_full |
Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_fullStr |
Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_full_unstemmed |
Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_sort |
investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| publisher |
Elsevier |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/44574/ http://irep.iium.edu.my/44574/ http://irep.iium.edu.my/44574/ http://irep.iium.edu.my/44574/1/Publication-Anil.pdf http://irep.iium.edu.my/44574/4/44574_Investigation%20of%20redox%20status%20in%20chronic%20cerebral%20hypoperfusion-induced%20neurodegeneration%20in%20rats_SCOPUS.pdf |
| first_indexed |
2023-09-18T21:03:22Z |
| last_indexed |
2023-09-18T21:03:22Z |
| _version_ |
1777410771141001216 |