TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia

TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations...

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Main Authors: Zainuddin, Norafiza, Murray, Fiona, Kanduri, Meena, Gunnarsson, Rebeqa, E. Smedby, Karin, Enblad, Gunilla, Jurlander, Jesper, Juliusson, Gunnar, Rosenquist, Richard
Format: Article
Language:English
Published: Pergamon 2011
Subjects:
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:http://irep.iium.edu.my/4434/
http://irep.iium.edu.my/4434/
http://irep.iium.edu.my/4434/
http://irep.iium.edu.my/4434/1/p53_CLL.pdf
id iium-4434
recordtype eprints
spelling iium-44342013-06-19T07:24:55Z http://irep.iium.edu.my/4434/ TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia Zainuddin, Norafiza Murray, Fiona Kanduri, Meena Gunnarsson, Rebeqa E. Smedby, Karin Enblad, Gunilla Jurlander, Jesper Juliusson, Gunnar Rosenquist, Richard RC0254 Neoplasms. Tumors. Oncology (including Cancer) TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3–6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. Pergamon 2011-02-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/4434/1/p53_CLL.pdf Zainuddin, Norafiza and Murray, Fiona and Kanduri, Meena and Gunnarsson, Rebeqa and E. Smedby, Karin and Enblad, Gunilla and Jurlander, Jesper and Juliusson, Gunnar and Rosenquist, Richard (2011) TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia. Leukemia Research, 35 (2). pp. 272-274. ISSN 0145-2126 http://www.sciencedirect.com/science/article/pii/S0145212610004285 10.1016/j.leukres.2010.08.023
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Zainuddin, Norafiza
Murray, Fiona
Kanduri, Meena
Gunnarsson, Rebeqa
E. Smedby, Karin
Enblad, Gunilla
Jurlander, Jesper
Juliusson, Gunnar
Rosenquist, Richard
TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia
description TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3–6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression.
format Article
author Zainuddin, Norafiza
Murray, Fiona
Kanduri, Meena
Gunnarsson, Rebeqa
E. Smedby, Karin
Enblad, Gunilla
Jurlander, Jesper
Juliusson, Gunnar
Rosenquist, Richard
author_facet Zainuddin, Norafiza
Murray, Fiona
Kanduri, Meena
Gunnarsson, Rebeqa
E. Smedby, Karin
Enblad, Gunilla
Jurlander, Jesper
Juliusson, Gunnar
Rosenquist, Richard
author_sort Zainuddin, Norafiza
title TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia
title_short TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia
title_full TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia
title_fullStr TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia
title_full_unstemmed TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia
title_sort tp53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia
publisher Pergamon
publishDate 2011
url http://irep.iium.edu.my/4434/
http://irep.iium.edu.my/4434/
http://irep.iium.edu.my/4434/
http://irep.iium.edu.my/4434/1/p53_CLL.pdf
first_indexed 2023-09-18T20:12:39Z
last_indexed 2023-09-18T20:12:39Z
_version_ 1777407580270755840

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