Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction

Compared to methadone, buprenorphine has a unique pharmacological profile in which it is a partial agonist at the mu- and NOP, but antagonist at the kappa-opioid receptors. This gives advantage to buprenorphine to have lesser abusive tendency and has ability to reduce relapse to drug taking. Previou...

Full description

Bibliographic Details
Main Authors:	Ahmad Bidin, Mohammad Ashraf, Rosman, Nurul Nazierah, Suhaimi, Maryam Saadah, Syd Mohmad Faudzi, Syed Mohd Syahmi, Ridzwan, Irna Elina
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/44337/ http://irep.iium.edu.my/44337/1/44337.pdf

id	iium-44337
recordtype	eprints
spelling	iium-443372016-05-23T03:06:51Z http://irep.iium.edu.my/44337/ Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction Ahmad Bidin, Mohammad Ashraf Rosman, Nurul Nazierah Suhaimi, Maryam Saadah Syd Mohmad Faudzi, Syed Mohd Syahmi Ridzwan, Irna Elina RS Pharmacy and materia medica Compared to methadone, buprenorphine has a unique pharmacological profile in which it is a partial agonist at the mu- and NOP, but antagonist at the kappa-opioid receptors. This gives advantage to buprenorphine to have lesser abusive tendency and has ability to reduce relapse to drug taking. Previous studies had shown that stress, which has been linked to relapse, increased the release of dynorphin (an endogenous kappa-opioid receptor agonist) and potentiates the rewarding effects of morphine. In this study, we tested if buprenorphine treatment has ability to block the drug seeking behaviour in mice using a conditioned place preference (CPP) paradigm. Initially, a modified forced-swim test (FST) was conducted for two consecutive days to induce stress by testing for immobility in mice. A significant difference between control and treatment groups (n = 8 for each group, P < 0.05) was observed on day 2 of FST trial which indicates the ability of buprenorphine (0.3 mg/kg) to reduce stress. Following FST, the mice were conditioned in two different compartments using biased method. The time spent in each compartment was calculated. It was found that there was no significant difference (P > 0.05) in the time spent for the treatment group (n = 8) during post morphine-conditioning session compared to their baseline, which suggested that buprenorphine has the ability to prevent morphine-seeking behaviour as compared to the control group (n = 8, P < 0.05) . These results suggest the advantage of buprenorphine as therapeutic agent to treat stress-induced relapse in drug addiction. 2015-06-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/44337/1/44337.pdf Ahmad Bidin, Mohammad Ashraf and Rosman, Nurul Nazierah and Suhaimi, Maryam Saadah and Syd Mohmad Faudzi, Syed Mohd Syahmi and Ridzwan, Irna Elina (2015) Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction. In: International Conference on Addiction Science (iCAS 2015), 8-9th June 2015, UniSZA.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ahmad Bidin, Mohammad Ashraf Rosman, Nurul Nazierah Suhaimi, Maryam Saadah Syd Mohmad Faudzi, Syed Mohd Syahmi Ridzwan, Irna Elina Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction
description	Compared to methadone, buprenorphine has a unique pharmacological profile in which it is a partial agonist at the mu- and NOP, but antagonist at the kappa-opioid receptors. This gives advantage to buprenorphine to have lesser abusive tendency and has ability to reduce relapse to drug taking. Previous studies had shown that stress, which has been linked to relapse, increased the release of dynorphin (an endogenous kappa-opioid receptor agonist) and potentiates the rewarding effects of morphine. In this study, we tested if buprenorphine treatment has ability to block the drug seeking behaviour in mice using a conditioned place preference (CPP) paradigm. Initially, a modified forced-swim test (FST) was conducted for two consecutive days to induce stress by testing for immobility in mice. A significant difference between control and treatment groups (n = 8 for each group, P < 0.05) was observed on day 2 of FST trial which indicates the ability of buprenorphine (0.3 mg/kg) to reduce stress. Following FST, the mice were conditioned in two different compartments using biased method. The time spent in each compartment was calculated. It was found that there was no significant difference (P > 0.05) in the time spent for the treatment group (n = 8) during post morphine-conditioning session compared to their baseline, which suggested that buprenorphine has the ability to prevent morphine-seeking behaviour as compared to the control group (n = 8, P < 0.05) . These results suggest the advantage of buprenorphine as therapeutic agent to treat stress-induced relapse in drug addiction.
format	Conference or Workshop Item
author	Ahmad Bidin, Mohammad Ashraf Rosman, Nurul Nazierah Suhaimi, Maryam Saadah Syd Mohmad Faudzi, Syed Mohd Syahmi Ridzwan, Irna Elina
author_facet	Ahmad Bidin, Mohammad Ashraf Rosman, Nurul Nazierah Suhaimi, Maryam Saadah Syd Mohmad Faudzi, Syed Mohd Syahmi Ridzwan, Irna Elina
author_sort	Ahmad Bidin, Mohammad Ashraf
title	Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction
title_short	Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction
title_full	Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction
title_fullStr	Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction
title_full_unstemmed	Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction
title_sort	anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction
publishDate	2015
url	http://irep.iium.edu.my/44337/ http://irep.iium.edu.my/44337/1/44337.pdf
first_indexed	2023-09-18T21:03:04Z
last_indexed	2023-09-18T21:03:04Z
_version_	1777410752334790656

Anti-stress properties of buprenorphine: a better choice for stress-induced relapse to drug addiction

Similar Items