Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice

Concurrent use of methamphetamine and morphine could give a synergistic effect, where it produce greater rewarding effects, and antagonize the side effects of each other, causing it to have a greater potential to be abused. This poly-drug abuse may lead to behavioral sensitization shown by stereot...

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Main Authors:	Suhaimi, Maryam Saadah, Ridzwan, Irna Elina, Muhamad, Abdul Halim, Mohd Ghazali, Masitah, Kasmuri, Abdul Razak, Mohd Nazar, Nor Ilyani, Hashim, Ridzwan, Syd Mohmad Faudzi, Syed Mohd Syahmi
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/44310/ http://irep.iium.edu.my/44310/1/ICBHSR_2015.pdf

id	iium-44310
recordtype	eprints
spelling	iium-443102015-08-20T00:47:36Z http://irep.iium.edu.my/44310/ Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice Suhaimi, Maryam Saadah Ridzwan, Irna Elina Muhamad, Abdul Halim Mohd Ghazali, Masitah Kasmuri, Abdul Razak Mohd Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi RS Pharmacy and materia medica Concurrent use of methamphetamine and morphine could give a synergistic effect, where it produce greater rewarding effects, and antagonize the side effects of each other, causing it to have a greater potential to be abused. This poly-drug abuse may lead to behavioral sensitization shown by stereotype behavior. The aim of this study is to compare the behavioral effects of priming dose in reinstatement model of morphine- and morphine/methamphetamine-dependent mice. Through conditioned place preference (CPP) test, dependence was successfully established by using 7.5 mg/kg morphine and/or 1 mglkg methamphetamine and then, extinction was achieved by retesting style. The mice were later challenged with priming dose of 2.5 mg/kg morphine and/or 'l mg/kg methamphetamine. Significant preference towards the drug-paired compartment were shown in both morphine- and morphine/methamphetamine-dependent mice (P<0.05 n=12). However, stereotyped behavior was developed only in morphinelmethamphetamine-dependent mice (45-60 mins). This result indicates that concurrent use of morphine and methamphetamine can induce behavioral sensitization in reinstatement modelof morphine/methamphetamine-dependence mice. This finding suggests that stereotype behavior can be one of the parameter to examine drug addiction and craving in animal model and to extend it to human. Thus, this study may lead to potential treatment for poly-drug abuse and the treatment should be designed to inhibit both reinstatement and behavioral sensitization effect of the drug^ Further study on relapse and behavioral sensitization in methamphetamine-dependent mice should be carried out to ascertain any cross-sensitization between morphine and methamphetamine. 2015-01 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/44310/1/ICBHSR_2015.pdf Suhaimi, Maryam Saadah and Ridzwan, Irna Elina and Muhamad, Abdul Halim and Mohd Ghazali, Masitah and Kasmuri, Abdul Razak and Mohd Nazar, Nor Ilyani and Hashim, Ridzwan and Syd Mohmad Faudzi, Syed Mohd Syahmi (2015) Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice. In: International Conference on Biomedical & Health Sciences Research (ICBHSR 2015), 25-27 Jan. 2015, The Everly Hotel, Putrajaya. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Suhaimi, Maryam Saadah Ridzwan, Irna Elina Muhamad, Abdul Halim Mohd Ghazali, Masitah Kasmuri, Abdul Razak Mohd Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice
description	Concurrent use of methamphetamine and morphine could give a synergistic effect, where it produce greater rewarding effects, and antagonize the side effects of each other, causing it to have a greater potential to be abused. This poly-drug abuse may lead to behavioral sensitization shown by stereotype behavior. The aim of this study is to compare the behavioral effects of priming dose in reinstatement model of morphine- and morphine/methamphetamine-dependent mice. Through conditioned place preference (CPP) test, dependence was successfully established by using 7.5 mg/kg morphine and/or 1 mglkg methamphetamine and then, extinction was achieved by retesting style. The mice were later challenged with priming dose of 2.5 mg/kg morphine and/or 'l mg/kg methamphetamine. Significant preference towards the drug-paired compartment were shown in both morphine- and morphine/methamphetamine-dependent mice (P<0.05 n=12). However, stereotyped behavior was developed only in morphinelmethamphetamine-dependent mice (45-60 mins). This result indicates that concurrent use of morphine and methamphetamine can induce behavioral sensitization in reinstatement modelof morphine/methamphetamine-dependence mice. This finding suggests that stereotype behavior can be one of the parameter to examine drug addiction and craving in animal model and to extend it to human. Thus, this study may lead to potential treatment for poly-drug abuse and the treatment should be designed to inhibit both reinstatement and behavioral sensitization effect of the drug^ Further study on relapse and behavioral sensitization in methamphetamine-dependent mice should be carried out to ascertain any cross-sensitization between morphine and methamphetamine.
format	Conference or Workshop Item
author	Suhaimi, Maryam Saadah Ridzwan, Irna Elina Muhamad, Abdul Halim Mohd Ghazali, Masitah Kasmuri, Abdul Razak Mohd Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi
author_facet	Suhaimi, Maryam Saadah Ridzwan, Irna Elina Muhamad, Abdul Halim Mohd Ghazali, Masitah Kasmuri, Abdul Razak Mohd Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi
author_sort	Suhaimi, Maryam Saadah
title	Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice
title_short	Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice
title_full	Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice
title_fullStr	Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice
title_full_unstemmed	Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice
title_sort	priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice
publishDate	2015
url	http://irep.iium.edu.my/44310/ http://irep.iium.edu.my/44310/1/ICBHSR_2015.pdf
first_indexed	2023-09-18T21:03:01Z
last_indexed	2023-09-18T21:03:01Z
_version_	1777410749195354112

Priming dose of morphine/methamphetamine combination induced stereotyped behavior in morphine/methamphetamine-dependent mice

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