Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes

S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS...

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Main Authors:	How, Fiona Ni Foong, Crouse, Karen A., M. Tahir, M. Ibrahim, Tarafder , M.T.H., Cowley, Andrew R.
Format:	Article
Language:	English
Published:	Elsevier 2008
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/1/Polyhedron_27_%282008%29_3325%E2%80%933329.pdf

id	iium-44289
recordtype	eprints
spelling	iium-442892017-08-17T08:10:27Z http://irep.iium.edu.my/44289/ Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R. QD Chemistry S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z' = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C=S, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond. SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia) while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens. Elsevier 2008-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44289/1/Polyhedron_27_%282008%29_3325%E2%80%933329.pdf How, Fiona Ni Foong and Crouse, Karen A. and M. Tahir, M. Ibrahim and Tarafder , M.T.H. and Cowley, Andrew R. (2008) Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes. Polyhedron, 27. pp. 3325-3329. ISSN 0277-5387 http://www.journals.elsevier.com/polyhedron/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R. Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
description	S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z' = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C=S, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond. SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia) while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens.
format	Article
author	How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R.
author_facet	How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R.
author_sort	How, Fiona Ni Foong
title	Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
title_short	Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
title_full	Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
title_fullStr	Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
title_full_unstemmed	Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
title_sort	synthesis, characterization and biological studies of s-benzyl-b-n-(benzoyl) dithiocarbazate and its metal complexes
publisher	Elsevier
publishDate	2008
url	http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/1/Polyhedron_27_%282008%29_3325%E2%80%933329.pdf
first_indexed	2023-09-18T21:02:59Z
last_indexed	2023-09-18T21:02:59Z
_version_	1777410746991247360

Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes

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