Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2008
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/1/Polyhedron_27_%282008%29_3325%E2%80%933329.pdf |
| Summary: | S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur
(OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated
complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative
bidentate ligand. The ligand and its metal complexes have been characterized by a variety of
physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z' = 2 in its thione
form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C=S, while the
S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond.
SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia)
while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective
activity towards targeted pathogens. |
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