The effect of diet control on the leptin levels in diabetic pregnant women

Leptin is an adipokine that has strong correlation with the body mass index (BMI). Gestational diabetes mellitus (GDM) is a common medical complication associated with pregnancy. Leptin may lose its correlation with the body mass index (BMI) during diabetes due to hormonal rearrangement. Diet cont...

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Main Authors:	Al-Kubaisi, Muna Khaleel Dheyab, Awang, Mokhtar, Abdulrazzaq, Saad Mohammed, Ahmed, A.A., John, Akbar
Format:	Article
Language:	English
Published:	The Faculty of Medicine, International Islamic University Malaysia 2015
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/43974/ http://irep.iium.edu.my/43974/ http://irep.iium.edu.my/43974/1/IMJM_Vol14No1_Page_59-63_The_Effect_of_Diet_Control_on_the_Leptin_Levels_in_Diabetic_Pregnant_Women.pdf

id	iium-43974
recordtype	eprints
spelling	iium-439742017-08-08T01:52:19Z http://irep.iium.edu.my/43974/ The effect of diet control on the leptin levels in diabetic pregnant women Al-Kubaisi, Muna Khaleel Dheyab Awang, Mokhtar Abdulrazzaq, Saad Mohammed Ahmed, A.A. John, Akbar R Medicine (General) Leptin is an adipokine that has strong correlation with the body mass index (BMI). Gestational diabetes mellitus (GDM) is a common medical complication associated with pregnancy. Leptin may lose its correlation with the body mass index (BMI) during diabetes due to hormonal rearrangement. Diet control is the first line management in GDM. Leptin reported to increase in pregnancy and further increases in diabetic patients during GDM screening. There is paucity in the reports concerning Leptin levels in GDM patients on diet control. The present study was aimed to evaluate the changes in maternal leptin in pregnancy complicated by GDM on diet control compared to the normal pregnancy in the 3rd trimesters by comparing the means and to find the correlation of Leptin with the body mass index in both groups. Methods: The study included 2 groups: normal pregnancy (n = 40) and pregnancy with GDM under diet control (n = 60) both groups are at 38-40 weeks of gestation. Leptin concentration in serum was measured in both groups and statistically tested using student t test. The BMI were measured and correlated with the Leptin level in test groups. Results: the results indicated that Leptin will nearly triple in the third trimester (38±30 ng/ml) of pregnancy compared to the standard normal non-pregnant. Leptin level was significantly lower in diabetic women on diet control (28±16 ng/ ml) when compared with the non-diabetics (38±30 ng/ml). The hormone has no correlation with the age of the patients but have a positive correlation with the body mass index before and during pregnancy in both groups. Conclusion: Leptin is increasing in pregnancy as part of the physiological changes. Dieting can decrease Leptin level in diabetics’ pregnant women. Diet can restore the hormonal dysregulation of Leptin. Assessment of Leptin level might be used as an indicator for good diet control during pregnancy. The Faculty of Medicine, International Islamic University Malaysia 2015-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/43974/1/IMJM_Vol14No1_Page_59-63_The_Effect_of_Diet_Control_on_the_Leptin_Levels_in_Diabetic_Pregnant_Women.pdf Al-Kubaisi, Muna Khaleel Dheyab and Awang, Mokhtar and Abdulrazzaq, Saad Mohammed and Ahmed, A.A. and John, Akbar (2015) The effect of diet control on the leptin levels in diabetic pregnant women. The International Medical Journal Malaysia, 14 (1). pp. 59-63. ISSN 1823-4631 http://iiumedic.net/imjm/v1/volume-14-no-1-june-2015/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Al-Kubaisi, Muna Khaleel Dheyab Awang, Mokhtar Abdulrazzaq, Saad Mohammed Ahmed, A.A. John, Akbar The effect of diet control on the leptin levels in diabetic pregnant women
description	Leptin is an adipokine that has strong correlation with the body mass index (BMI). Gestational diabetes mellitus (GDM) is a common medical complication associated with pregnancy. Leptin may lose its correlation with the body mass index (BMI) during diabetes due to hormonal rearrangement. Diet control is the first line management in GDM. Leptin reported to increase in pregnancy and further increases in diabetic patients during GDM screening. There is paucity in the reports concerning Leptin levels in GDM patients on diet control. The present study was aimed to evaluate the changes in maternal leptin in pregnancy complicated by GDM on diet control compared to the normal pregnancy in the 3rd trimesters by comparing the means and to find the correlation of Leptin with the body mass index in both groups. Methods: The study included 2 groups: normal pregnancy (n = 40) and pregnancy with GDM under diet control (n = 60) both groups are at 38-40 weeks of gestation. Leptin concentration in serum was measured in both groups and statistically tested using student t test. The BMI were measured and correlated with the Leptin level in test groups. Results: the results indicated that Leptin will nearly triple in the third trimester (38±30 ng/ml) of pregnancy compared to the standard normal non-pregnant. Leptin level was significantly lower in diabetic women on diet control (28±16 ng/ ml) when compared with the non-diabetics (38±30 ng/ml). The hormone has no correlation with the age of the patients but have a positive correlation with the body mass index before and during pregnancy in both groups. Conclusion: Leptin is increasing in pregnancy as part of the physiological changes. Dieting can decrease Leptin level in diabetics’ pregnant women. Diet can restore the hormonal dysregulation of Leptin. Assessment of Leptin level might be used as an indicator for good diet control during pregnancy.
format	Article
author	Al-Kubaisi, Muna Khaleel Dheyab Awang, Mokhtar Abdulrazzaq, Saad Mohammed Ahmed, A.A. John, Akbar
author_facet	Al-Kubaisi, Muna Khaleel Dheyab Awang, Mokhtar Abdulrazzaq, Saad Mohammed Ahmed, A.A. John, Akbar
author_sort	Al-Kubaisi, Muna Khaleel Dheyab
title	The effect of diet control on the leptin levels in diabetic pregnant women
title_short	The effect of diet control on the leptin levels in diabetic pregnant women
title_full	The effect of diet control on the leptin levels in diabetic pregnant women
title_fullStr	The effect of diet control on the leptin levels in diabetic pregnant women
title_full_unstemmed	The effect of diet control on the leptin levels in diabetic pregnant women
title_sort	effect of diet control on the leptin levels in diabetic pregnant women
publisher	The Faculty of Medicine, International Islamic University Malaysia
publishDate	2015
url	http://irep.iium.edu.my/43974/ http://irep.iium.edu.my/43974/ http://irep.iium.edu.my/43974/1/IMJM_Vol14No1_Page_59-63_The_Effect_of_Diet_Control_on_the_Leptin_Levels_in_Diabetic_Pregnant_Women.pdf
first_indexed	2023-09-18T21:02:33Z
last_indexed	2023-09-18T21:02:33Z
_version_	1777410720241025024

The effect of diet control on the leptin levels in diabetic pregnant women

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