Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice

This study was conducted to evaluate the phytochemical content and antimalarial properties of the essential oil from the leaves of Malaysian Plectranthus amboinicus. The essential oil was prepared by using steam distillation technique and subjected to phytochemical screening by using GC-MS. Antimala...

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Main Author:	Oothuman, Pakeer
Format:	Monograph
Language:	English
Published:	s.n 2015
Subjects:	QR Microbiology
Online Access:	http://irep.iium.edu.my/43763/ http://irep.iium.edu.my/43763/2/NORAZSIDA_full_version_of_research_report-1.pdf

id	iium-43763
recordtype	eprints
spelling	iium-437632015-11-02T00:38:31Z http://irep.iium.edu.my/43763/ Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice Oothuman, Pakeer QR Microbiology This study was conducted to evaluate the phytochemical content and antimalarial properties of the essential oil from the leaves of Malaysian Plectranthus amboinicus. The essential oil was prepared by using steam distillation technique and subjected to phytochemical screening by using GC-MS. Antimalarial activity of different extract doses of 50, 200, 400 and 1000 µL/kg were tested in vivo against Plasmodium berghei (PZZ1/100) infections in mice (6 mice for each group) during early, established and residual infections. Totally 7 compounds were identified and account for about 88.59% of total oil. The major chemical compounds were carvacrol (85.14%), followed by thymoquinone (1.65%), terpinen-4-ol (0.70%), octenol (0.62%), thymol (0.23%), dioctylazelate (0.15%) and phthalic acid (0.10%). Antimalarial assay suggested this essential oil as a potential prophylactic agent (% chemo suppression: 45.23%, 18.28%, 45.38% and 58.26% while treated with 50, 200, 400 and 1000 µL/kg of essential oil respectively) and curative agent (% chemo suppression: 54.10%, 47.35%, 56.75% and 65.38% while treated with 50, 200, 400 and 1000 µL/kg of essential oil respectively) . Statistically no reduction of parasitemia was seen calculated for suppressive test. Thus, the isolation of active compound of this extract may give a promising drug molecule to be used as prophylactic and curative agent of malaria. s.n 2015-07-06 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/43763/2/NORAZSIDA_full_version_of_research_report-1.pdf Oothuman, Pakeer (2015) Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice. Research Report. s.n. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QR Microbiology
spellingShingle	QR Microbiology Oothuman, Pakeer Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice
description	This study was conducted to evaluate the phytochemical content and antimalarial properties of the essential oil from the leaves of Malaysian Plectranthus amboinicus. The essential oil was prepared by using steam distillation technique and subjected to phytochemical screening by using GC-MS. Antimalarial activity of different extract doses of 50, 200, 400 and 1000 µL/kg were tested in vivo against Plasmodium berghei (PZZ1/100) infections in mice (6 mice for each group) during early, established and residual infections. Totally 7 compounds were identified and account for about 88.59% of total oil. The major chemical compounds were carvacrol (85.14%), followed by thymoquinone (1.65%), terpinen-4-ol (0.70%), octenol (0.62%), thymol (0.23%), dioctylazelate (0.15%) and phthalic acid (0.10%). Antimalarial assay suggested this essential oil as a potential prophylactic agent (% chemo suppression: 45.23%, 18.28%, 45.38% and 58.26% while treated with 50, 200, 400 and 1000 µL/kg of essential oil respectively) and curative agent (% chemo suppression: 54.10%, 47.35%, 56.75% and 65.38% while treated with 50, 200, 400 and 1000 µL/kg of essential oil respectively) . Statistically no reduction of parasitemia was seen calculated for suppressive test. Thus, the isolation of active compound of this extract may give a promising drug molecule to be used as prophylactic and curative agent of malaria.
format	Monograph
author	Oothuman, Pakeer
author_facet	Oothuman, Pakeer
author_sort	Oothuman, Pakeer
title	Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice
title_short	Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice
title_full	Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice
title_fullStr	Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice
title_full_unstemmed	Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice
title_sort	evaluation of the use of the essential oil of malaysian plectranthus amboinicus (lour) spreng as antimalarial in mice
publisher	s.n
publishDate	2015
url	http://irep.iium.edu.my/43763/ http://irep.iium.edu.my/43763/2/NORAZSIDA_full_version_of_research_report-1.pdf
first_indexed	2023-09-18T21:02:18Z
last_indexed	2023-09-18T21:02:18Z
_version_	1777410704323641344

Evaluation of the use of the essential oil of Malaysian Plectranthus Amboinicus (LOUR) spreng as antimalarial in mice

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