Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.

Recent advances in neuro-oncology have revealed different pathways of molecular oncogenesis in malignant gliomas including loss of heterozygosity on chromosomal regions harboring tumor suppressor genes. In the present study, we performed polymerase chain reaction-loss of heterozygosity (PCR-LOH) ana...

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Main Authors:	Zainuddin, Norafiza, Jaafar, Hasnan, Isa, Mohd. Nizam, Abdullah, Jafri Malin
Format:	Article
Language:	English
Published:	Maney Publishing 2004
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/43755/ http://irep.iium.edu.my/43755/ http://irep.iium.edu.my/43755/ http://irep.iium.edu.my/43755/2/Loss_of_heterozygosity_on_chromosomes.pdf

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recordtype	eprints
spelling	iium-437552015-07-28T02:09:34Z http://irep.iium.edu.my/43755/ Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma. Zainuddin, Norafiza Jaafar, Hasnan Isa, Mohd. Nizam Abdullah, Jafri Malin RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Recent advances in neuro-oncology have revealed different pathways of molecular oncogenesis in malignant gliomas including loss of heterozygosity on chromosomal regions harboring tumor suppressor genes. In the present study, we performed polymerase chain reaction-loss of heterozygosity (PCR-LOH) analysis using microsatellite markers to identify loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in the Malays with malignant gliomas. Of 12 cases with allelic losses, seven (58.3%) cases showed LOH on chromosome 10q, three (25.0%) cases showed LOH on chromosome 9p, four (33.3%) cases showed LOH on chromosome 17p and two (16.7%) cases showed LOH on chromosome 13q. The cases include five (41.7%) cases of glioblastoma multiforme, three (25.0%) cases of anaplastic astrocytoma, three (25.0%) cases of anaplastic oligodendroglioma and one (8.3%) case of anaplastic ependymoma. Four cases showed loss of heterozygosity on more than one locus. Our findings showed that loss of heterozygosity on specific chromosomal regions contributes to the molecular pathway of glioma progression in Malay population. In addition, these data provide useful evidence of molecular genetic alterations of malignant glioma in South East Asian patients, particularly in the East Coast of Malaysia. Maney Publishing 2004 Article PeerReviewed application/pdf en http://irep.iium.edu.my/43755/2/Loss_of_heterozygosity_on_chromosomes.pdf Zainuddin, Norafiza and Jaafar, Hasnan and Isa, Mohd. Nizam and Abdullah, Jafri Malin (2004) Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma. Neurological Research , 26 (1). pp. 88-92. ISSN 0161-6412 http://maneypublishing.com/index.php/journals/ner/ http://dx.doi.org/10.1179/016164104773026598
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Zainuddin, Norafiza Jaafar, Hasnan Isa, Mohd. Nizam Abdullah, Jafri Malin Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
description	Recent advances in neuro-oncology have revealed different pathways of molecular oncogenesis in malignant gliomas including loss of heterozygosity on chromosomal regions harboring tumor suppressor genes. In the present study, we performed polymerase chain reaction-loss of heterozygosity (PCR-LOH) analysis using microsatellite markers to identify loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in the Malays with malignant gliomas. Of 12 cases with allelic losses, seven (58.3%) cases showed LOH on chromosome 10q, three (25.0%) cases showed LOH on chromosome 9p, four (33.3%) cases showed LOH on chromosome 17p and two (16.7%) cases showed LOH on chromosome 13q. The cases include five (41.7%) cases of glioblastoma multiforme, three (25.0%) cases of anaplastic astrocytoma, three (25.0%) cases of anaplastic oligodendroglioma and one (8.3%) case of anaplastic ependymoma. Four cases showed loss of heterozygosity on more than one locus. Our findings showed that loss of heterozygosity on specific chromosomal regions contributes to the molecular pathway of glioma progression in Malay population. In addition, these data provide useful evidence of molecular genetic alterations of malignant glioma in South East Asian patients, particularly in the East Coast of Malaysia.
format	Article
author	Zainuddin, Norafiza Jaafar, Hasnan Isa, Mohd. Nizam Abdullah, Jafri Malin
author_facet	Zainuddin, Norafiza Jaafar, Hasnan Isa, Mohd. Nizam Abdullah, Jafri Malin
author_sort	Zainuddin, Norafiza
title	Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
title_short	Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
title_full	Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
title_fullStr	Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
title_full_unstemmed	Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
title_sort	loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
publisher	Maney Publishing
publishDate	2004
url	http://irep.iium.edu.my/43755/ http://irep.iium.edu.my/43755/ http://irep.iium.edu.my/43755/ http://irep.iium.edu.my/43755/2/Loss_of_heterozygosity_on_chromosomes.pdf
first_indexed	2023-09-18T21:02:17Z
last_indexed	2023-09-18T21:02:17Z
_version_	1777410703743778816

Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.

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