Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats

Objective: of this study was to evaluate the antihypertensive potential of Thymoquinone TQ and to investigate the underlying mechanism of action. Method: Hypertension was induced in in Sprague Dawley rats (n = 40) by administration of L-Nitro-Arginine Methyl Ester (L-NAME) in drinking water for 4...

Full description

Bibliographic Details
Main Authors:	Azzubaidi, Marwan Saad, Noor, Noriah Mohd, Mizher, Hussam A.
Format:	Article
Language:	English English
Published:	Wolters Kluwer 2015
Subjects:	R Medicine (General) RC Internal medicine RM Therapeutics. Pharmacology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/43748/ http://irep.iium.edu.my/43748/ http://irep.iium.edu.my/43748/5/43748.pdf http://irep.iium.edu.my/43748/8/J_HT.pdf

id	iium-43748
recordtype	eprints
spelling	iium-437482015-07-14T02:13:38Z http://irep.iium.edu.my/43748/ Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats Azzubaidi, Marwan Saad Noor, Noriah Mohd Mizher, Hussam A. R Medicine (General) RC Internal medicine RM Therapeutics. Pharmacology RM300 Drugs and their action Objective: of this study was to evaluate the antihypertensive potential of Thymoquinone TQ and to investigate the underlying mechanism of action. Method: Hypertension was induced in in Sprague Dawley rats (n = 40) by administration of L-Nitro-Arginine Methyl Ester (L-NAME) in drinking water for 4 weeks. At the end of induction period, rats were divided into 6 groups (n = 8); TQ2.5+L-NAME, TQ5+L-NAME, TQ10+L-NAME, captopril+L-NAME, L-NAME only and control. Mean arterial pressure (MAP) and hear rate (HR) were recorded by the non-invasive tail cuff technique weekly for 28 days. Then animals were sacrificed and blood was collected for determination of ACE activity and aldosterone concentration using ELISA. Lipid profile (total cholesterol, LDL, HDL, TRG) was assayed twice; at the end of induction period and at the end of treatment period. Results: TQ reversed the established hypertension in TQ5 and TQ10 groups, and prevented further increase in MAP in TQ2.5 group. Unlike captopril treated group, TQ antihypertensive activity was associated with an increase in serum aldosterone concentration and ACE activity. TQ treatment at the high dose significantly lowered total cholesterol and LDL levels in comparison with the healthy control group at the end of the 4th week of treatment. Conclusion: This study confirms the antihypertensive effect of TQ which did not take place through inhibition of ACE, but probably through blocking angiotensin II receptors. Wolters Kluwer 2015-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/43748/5/43748.pdf application/pdf en http://irep.iium.edu.my/43748/8/J_HT.pdf Azzubaidi, Marwan Saad and Noor, Noriah Mohd and Mizher, Hussam A. (2015) Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats. Journal of Hypertension, 33 (supp 2). e7-e7. ISSN 0263-6352 http://journals.lww.com/jhypertension/pages/default.aspx
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RC Internal medicine RM Therapeutics. Pharmacology RM300 Drugs and their action
spellingShingle	R Medicine (General) RC Internal medicine RM Therapeutics. Pharmacology RM300 Drugs and their action Azzubaidi, Marwan Saad Noor, Noriah Mohd Mizher, Hussam A. Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
description	Objective: of this study was to evaluate the antihypertensive potential of Thymoquinone TQ and to investigate the underlying mechanism of action. Method: Hypertension was induced in in Sprague Dawley rats (n = 40) by administration of L-Nitro-Arginine Methyl Ester (L-NAME) in drinking water for 4 weeks. At the end of induction period, rats were divided into 6 groups (n = 8); TQ2.5+L-NAME, TQ5+L-NAME, TQ10+L-NAME, captopril+L-NAME, L-NAME only and control. Mean arterial pressure (MAP) and hear rate (HR) were recorded by the non-invasive tail cuff technique weekly for 28 days. Then animals were sacrificed and blood was collected for determination of ACE activity and aldosterone concentration using ELISA. Lipid profile (total cholesterol, LDL, HDL, TRG) was assayed twice; at the end of induction period and at the end of treatment period. Results: TQ reversed the established hypertension in TQ5 and TQ10 groups, and prevented further increase in MAP in TQ2.5 group. Unlike captopril treated group, TQ antihypertensive activity was associated with an increase in serum aldosterone concentration and ACE activity. TQ treatment at the high dose significantly lowered total cholesterol and LDL levels in comparison with the healthy control group at the end of the 4th week of treatment. Conclusion: This study confirms the antihypertensive effect of TQ which did not take place through inhibition of ACE, but probably through blocking angiotensin II receptors.
format	Article
author	Azzubaidi, Marwan Saad Noor, Noriah Mohd Mizher, Hussam A.
author_facet	Azzubaidi, Marwan Saad Noor, Noriah Mohd Mizher, Hussam A.
author_sort	Azzubaidi, Marwan Saad
title	Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
title_short	Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
title_full	Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
title_fullStr	Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
title_full_unstemmed	Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
title_sort	antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
publisher	Wolters Kluwer
publishDate	2015
url	http://irep.iium.edu.my/43748/ http://irep.iium.edu.my/43748/ http://irep.iium.edu.my/43748/5/43748.pdf http://irep.iium.edu.my/43748/8/J_HT.pdf
first_indexed	2023-09-18T21:02:17Z
last_indexed	2023-09-18T21:02:17Z
_version_	1777410702985658368

Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats

Similar Items