In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract

Introduction: Currently, researchers are aiming to explore herbal plants to replace synthetic drugs because herbal plants contain high active compounds and fewer side effects. Our study was done to determine the antibacterial activity of Eurycoma longifolia Jack (E. longifolia) root using ethanol...

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Main Authors:	Faisal, Ghasak Ghazi, Najmuldeen, Ghazi Faisal, Zakaria, Siti Mastura
Format:	Article
Language:	English
Published:	The Faculty of Medicine, International Islamic University Malaysia 2015
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/43526/ http://irep.iium.edu.my/43526/ http://irep.iium.edu.my/43526/1/IMJM%2520Vol14No1%2520Page%252077-81%2520In%2520Vitro%2520Antibacterial%2520Activity%2520of%2520Eurycoma%2520Longifolia.pdf

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spelling	iium-435262017-08-03T08:28:39Z http://irep.iium.edu.my/43526/ In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract Faisal, Ghasak Ghazi Najmuldeen, Ghazi Faisal Zakaria, Siti Mastura R Medicine (General) RB Pathology Introduction: Currently, researchers are aiming to explore herbal plants to replace synthetic drugs because herbal plants contain high active compounds and fewer side effects. Our study was done to determine the antibacterial activity of Eurycoma longifolia Jack (E. longifolia) root using ethanol based extract. Methods: Five types of pathogenic bacterial strains were used; Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa). Disc diffusion assay and Minimum Inhibitory Concentration (MIC) tests were used to determine the inhibition zone and turbidity of suspension which reflects the antibacterial activity of the extract. Results: The ethanolic extract of E. longifolia Jack root extract showed positive results against Gram-positive bacteria (S. aureus and B. cereus) and Gramnegative (S. typhi). B.cereus and S.typhi showed inhibition zone values of 11.76mm and 14.33mm at the extract concentration of 150mg/ml that were higher than the positive control values (9.00, 12.67mm) respectively. However, E. coli and P. aeruginosa did not show any inhibition by the ethanol-based extract. Conclusion: From the results we can conclude that E.Longifolia root extract possesses antibacterial activity that can be further explored to produce new medicinal products. The Faculty of Medicine, International Islamic University Malaysia 2015-06-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/43526/1/IMJM%2520Vol14No1%2520Page%252077-81%2520In%2520Vitro%2520Antibacterial%2520Activity%2520of%2520Eurycoma%2520Longifolia.pdf Faisal, Ghasak Ghazi and Najmuldeen, Ghazi Faisal and Zakaria, Siti Mastura (2015) In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract. The International Medical Journal Malaysia, 14 (1). pp. 77-81. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2014%20No%201/3%20Original%20Articles/IMJM%20Vol14No1%20Page%2077-81%20In%20Vitro%20Antibacterial%20Activity%20of%20Eurycoma%20Longifolia.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Faisal, Ghasak Ghazi Najmuldeen, Ghazi Faisal Zakaria, Siti Mastura In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract
description	Introduction: Currently, researchers are aiming to explore herbal plants to replace synthetic drugs because herbal plants contain high active compounds and fewer side effects. Our study was done to determine the antibacterial activity of Eurycoma longifolia Jack (E. longifolia) root using ethanol based extract. Methods: Five types of pathogenic bacterial strains were used; Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa). Disc diffusion assay and Minimum Inhibitory Concentration (MIC) tests were used to determine the inhibition zone and turbidity of suspension which reflects the antibacterial activity of the extract. Results: The ethanolic extract of E. longifolia Jack root extract showed positive results against Gram-positive bacteria (S. aureus and B. cereus) and Gramnegative (S. typhi). B.cereus and S.typhi showed inhibition zone values of 11.76mm and 14.33mm at the extract concentration of 150mg/ml that were higher than the positive control values (9.00, 12.67mm) respectively. However, E. coli and P. aeruginosa did not show any inhibition by the ethanol-based extract. Conclusion: From the results we can conclude that E.Longifolia root extract possesses antibacterial activity that can be further explored to produce new medicinal products.
format	Article
author	Faisal, Ghasak Ghazi Najmuldeen, Ghazi Faisal Zakaria, Siti Mastura
author_facet	Faisal, Ghasak Ghazi Najmuldeen, Ghazi Faisal Zakaria, Siti Mastura
author_sort	Faisal, Ghasak Ghazi
title	In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract
title_short	In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract
title_full	In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract
title_fullStr	In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract
title_full_unstemmed	In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract
title_sort	in vitro antibacterial activity of eurycoma longifolia jack (tongkat ali) root extract
publisher	The Faculty of Medicine, International Islamic University Malaysia
publishDate	2015
url	http://irep.iium.edu.my/43526/ http://irep.iium.edu.my/43526/ http://irep.iium.edu.my/43526/1/IMJM%2520Vol14No1%2520Page%252077-81%2520In%2520Vitro%2520Antibacterial%2520Activity%2520of%2520Eurycoma%2520Longifolia.pdf
first_indexed	2023-09-18T21:02:01Z
last_indexed	2023-09-18T21:02:01Z
_version_	1777410686613192704

In vitro antibacterial activity of Eurycoma longifolia jack (Tongkat ali) root extract

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