Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering

The aim of this study is to develop a facile and efficient scaffold from electrospun hydroxyethyl cellulose (HEC) functionalized with bone-like calcium phosphate (CaP). The HEC/PVA nanofibers were fabricated by electrospinning and mineralized by incubating in 10× simulated body fluid (SBF) for diffe...

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Main Authors:	Chahal, Sugandha, Hussain, Fathima Shahitha Jahir, Kumar, Anuj, M. Yusof, Mashitah, Abdull Rasad, Mohammad Syaiful Bahari
Format:	Article
Language:	English English
Published:	The Royal Society of Chemistry 2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/42926/ http://irep.iium.edu.my/42926/ http://irep.iium.edu.my/42926/ http://irep.iium.edu.my/42926/1/RSC_Advances.pdf http://irep.iium.edu.my/42926/4/42926_Electrospun%20hydroxyethyl%20cellulose%20nanofibers_SCOPUS.pdf

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spelling	iium-429262017-11-08T04:34:09Z http://irep.iium.edu.my/42926/ Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering Chahal, Sugandha Hussain, Fathima Shahitha Jahir Kumar, Anuj M. Yusof, Mashitah Abdull Rasad, Mohammad Syaiful Bahari Q Science (General) The aim of this study is to develop a facile and efficient scaffold from electrospun hydroxyethyl cellulose (HEC) functionalized with bone-like calcium phosphate (CaP). The HEC/PVA nanofibers were fabricated by electrospinning and mineralized by incubating in 10× simulated body fluid (SBF) for different period of times. After 24h of incubation, the nanofibers were uniformly coated by a thin layer of mineral deposit. SEM, FTIR, and FESEM-EDS analysis confirm the deposition of CaP on the nanofibers. The nanostructured biomaterial maintained its fibrous and porous structure after mineralization. The XRD results suggest that the deposited mineral phase is a mixture of calcium phosphate hydrate and apatite. The mechanical properties of CaP coated scaffolds has similar tensile strength and elastic modulus with that of trabecular and proximal femoral bones. The cytocompatibility of the CaP coated HEC/PVA scaffolds were evaluated using human osteosarcoma cells. The CaP coated HEC/PVA scaffolds supports cellular attachment and proliferation of osteosarcoma cells and will be a promising candidate for bone tissue engineering. The Royal Society of Chemistry 2015-03-17 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42926/1/RSC_Advances.pdf application/pdf en http://irep.iium.edu.my/42926/4/42926_Electrospun%20hydroxyethyl%20cellulose%20nanofibers_SCOPUS.pdf Chahal, Sugandha and Hussain, Fathima Shahitha Jahir and Kumar, Anuj and M. Yusof, Mashitah and Abdull Rasad, Mohammad Syaiful Bahari (2015) Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering. RSC Avances, 5. pp. 29497-29504. http://pubs.rsc.org/en/Journals/JournalIssues/RA?e=1 10.1039/c4ra17087c
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Chahal, Sugandha Hussain, Fathima Shahitha Jahir Kumar, Anuj M. Yusof, Mashitah Abdull Rasad, Mohammad Syaiful Bahari Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
description	The aim of this study is to develop a facile and efficient scaffold from electrospun hydroxyethyl cellulose (HEC) functionalized with bone-like calcium phosphate (CaP). The HEC/PVA nanofibers were fabricated by electrospinning and mineralized by incubating in 10× simulated body fluid (SBF) for different period of times. After 24h of incubation, the nanofibers were uniformly coated by a thin layer of mineral deposit. SEM, FTIR, and FESEM-EDS analysis confirm the deposition of CaP on the nanofibers. The nanostructured biomaterial maintained its fibrous and porous structure after mineralization. The XRD results suggest that the deposited mineral phase is a mixture of calcium phosphate hydrate and apatite. The mechanical properties of CaP coated scaffolds has similar tensile strength and elastic modulus with that of trabecular and proximal femoral bones. The cytocompatibility of the CaP coated HEC/PVA scaffolds were evaluated using human osteosarcoma cells. The CaP coated HEC/PVA scaffolds supports cellular attachment and proliferation of osteosarcoma cells and will be a promising candidate for bone tissue engineering.
format	Article
author	Chahal, Sugandha Hussain, Fathima Shahitha Jahir Kumar, Anuj M. Yusof, Mashitah Abdull Rasad, Mohammad Syaiful Bahari
author_facet	Chahal, Sugandha Hussain, Fathima Shahitha Jahir Kumar, Anuj M. Yusof, Mashitah Abdull Rasad, Mohammad Syaiful Bahari
author_sort	Chahal, Sugandha
title	Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
title_short	Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
title_full	Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
title_fullStr	Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
title_full_unstemmed	Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
title_sort	electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
publisher	The Royal Society of Chemistry
publishDate	2015
url	http://irep.iium.edu.my/42926/ http://irep.iium.edu.my/42926/ http://irep.iium.edu.my/42926/ http://irep.iium.edu.my/42926/1/RSC_Advances.pdf http://irep.iium.edu.my/42926/4/42926_Electrospun%20hydroxyethyl%20cellulose%20nanofibers_SCOPUS.pdf
first_indexed	2023-09-18T21:01:10Z
last_indexed	2023-09-18T21:01:10Z
_version_	1777410632757280768

Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering

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