The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats

Background: The National Health and Morbidity Survey in 2011 estimated that 35.1% (5.7 million) of Malaysian adults aged 18 and older suffer from hypertension. Hypertension is still treated by conventional medicine despite its exact aetiology being unknown. Studies showed that oxidative stress and...

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Main Authors:	Mohd Zainudin, Maizura, Zakaria, Zaiton, Megat Mohd Nordin, Nor Anita
Format:	Article
Language:	English English English
Published:	BioMed Central 2015
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/1/PIPER_BMC_ARTICLE.pdf http://irep.iium.edu.my/42713/7/42713_the_use_of_piper.pdf http://irep.iium.edu.my/42713/10/42713_The%20use%20of%20piper%20sarmentosum%20leaves%20aqueous_SCOPUS.pdf

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recordtype	eprints
spelling	iium-427132017-11-07T08:26:13Z http://irep.iium.edu.my/42713/ The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats Mohd Zainudin, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita R Medicine (General) RM Therapeutics. Pharmacology Background: The National Health and Morbidity Survey in 2011 estimated that 35.1% (5.7 million) of Malaysian adults aged 18 and older suffer from hypertension. Hypertension is still treated by conventional medicine despite its exact aetiology being unknown. Studies showed that oxidative stress and low availability of nitric oxide (NO) causes an increase in vascular wall tension and increase blood pressure. Piper sarmentosum (PS) a traditional Malay herbal plant is well known for its high antioxidant content. Antioxidant is useful in improving cardiovascular diseases particularly hypertension. Thus, it is beneficial to determine the effect of PS leaves aqueous extract (Kadukmy™) on the blood pressure, NO level, oxidative stress markers and serum cholesterol level of the Spontaneous Hypertensive Rats (SHR). Methods: Rats were devided into five groups consisting of three treatment groups and two control groups. Baseline blood investigations were done before and following commencement of treatment. Spontaneous hypertensive rats were treated for 28 consecutive days and the blood pressure was measured weekly. Results: Kadukmy™ administration showed a significant reduction in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) (P < 0.05), increased serum NO level (P < 0.05), reduced serum malondialdehyde (MDA) level (P < 0.05) and reduction of serum total cholesterol level in groups treated with Kadukmy-1™. Conclusions: The result of the present study revealed that Kadukmy™ exerts its antioxidant activity to reduce oxidative stress damage, increase NO production and able to reduce blood pressure and cholesterol level. BioMed Central 2015-03-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42713/1/PIPER_BMC_ARTICLE.pdf application/pdf en http://irep.iium.edu.my/42713/7/42713_the_use_of_piper.pdf application/pdf en http://irep.iium.edu.my/42713/10/42713_The%20use%20of%20piper%20sarmentosum%20leaves%20aqueous_SCOPUS.pdf Mohd Zainudin, Maizura and Zakaria, Zaiton and Megat Mohd Nordin, Nor Anita (2015) The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats. BMC Complementary and Alternative Medicine, 15 (1). pp. 1-10. ISSN 1472-6882 http://www.biomedcentral.com/1472-6882/15/54. 10.1186/s12906-015-0565-z
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General) RM Therapeutics. Pharmacology
spellingShingle	R Medicine (General) RM Therapeutics. Pharmacology Mohd Zainudin, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
description	Background: The National Health and Morbidity Survey in 2011 estimated that 35.1% (5.7 million) of Malaysian adults aged 18 and older suffer from hypertension. Hypertension is still treated by conventional medicine despite its exact aetiology being unknown. Studies showed that oxidative stress and low availability of nitric oxide (NO) causes an increase in vascular wall tension and increase blood pressure. Piper sarmentosum (PS) a traditional Malay herbal plant is well known for its high antioxidant content. Antioxidant is useful in improving cardiovascular diseases particularly hypertension. Thus, it is beneficial to determine the effect of PS leaves aqueous extract (Kadukmy™) on the blood pressure, NO level, oxidative stress markers and serum cholesterol level of the Spontaneous Hypertensive Rats (SHR). Methods: Rats were devided into five groups consisting of three treatment groups and two control groups. Baseline blood investigations were done before and following commencement of treatment. Spontaneous hypertensive rats were treated for 28 consecutive days and the blood pressure was measured weekly. Results: Kadukmy™ administration showed a significant reduction in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) (P < 0.05), increased serum NO level (P < 0.05), reduced serum malondialdehyde (MDA) level (P < 0.05) and reduction of serum total cholesterol level in groups treated with Kadukmy-1™. Conclusions: The result of the present study revealed that Kadukmy™ exerts its antioxidant activity to reduce oxidative stress damage, increase NO production and able to reduce blood pressure and cholesterol level.
format	Article
author	Mohd Zainudin, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita
author_facet	Mohd Zainudin, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita
author_sort	Mohd Zainudin, Maizura
title	The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
title_short	The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
title_full	The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
title_fullStr	The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
title_full_unstemmed	The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
title_sort	use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
publisher	BioMed Central
publishDate	2015
url	http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/1/PIPER_BMC_ARTICLE.pdf http://irep.iium.edu.my/42713/7/42713_the_use_of_piper.pdf http://irep.iium.edu.my/42713/10/42713_The%20use%20of%20piper%20sarmentosum%20leaves%20aqueous_SCOPUS.pdf
first_indexed	2023-09-18T21:00:52Z
last_indexed	2023-09-18T21:00:52Z
_version_	1777410613937438720

The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats

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