The use of piper sarmentosum leaves aqueous extract (kadukmy™) as antihypertensive agent in spontaneous hypertensive rats
Background: The National Health and Morbidity Survey in 2011 estimated that 35.1% (5.7 million) of Malaysian adults aged 18 and older suffer from hypertension. Hypertension is still treated by conventional medicine despite its exact aetiology being unknown. Studies showed that oxidative stress and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
BioMed Central
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/ http://irep.iium.edu.my/42713/1/PIPER_BMC_ARTICLE.pdf http://irep.iium.edu.my/42713/7/42713_the_use_of_piper.pdf http://irep.iium.edu.my/42713/10/42713_The%20use%20of%20piper%20sarmentosum%20leaves%20aqueous_SCOPUS.pdf |
| Summary: | Background: The National Health and Morbidity Survey in 2011 estimated that 35.1% (5.7 million) of Malaysian
adults aged 18 and older suffer from hypertension. Hypertension is still treated by conventional medicine despite
its exact aetiology being unknown. Studies showed that oxidative stress and low availability of nitric oxide (NO)
causes an increase in vascular wall tension and increase blood pressure. Piper sarmentosum (PS) a traditional Malay
herbal plant is well known for its high antioxidant content. Antioxidant is useful in improving cardiovascular
diseases particularly hypertension. Thus, it is beneficial to determine the effect of PS leaves aqueous extract
(Kadukmy™) on the blood pressure, NO level, oxidative stress markers and serum cholesterol level of the
Spontaneous Hypertensive Rats (SHR).
Methods: Rats were devided into five groups consisting of three treatment groups and two control groups.
Baseline blood investigations were done before and following commencement of treatment. Spontaneous
hypertensive rats were treated for 28 consecutive days and the blood pressure was measured weekly.
Results: Kadukmy™ administration showed a significant reduction in systolic blood pressure (SBP), diastolic blood
pressure (DBP) and mean arterial pressure (MAP) (P < 0.05), increased serum NO level (P < 0.05), reduced serum
malondialdehyde (MDA) level (P < 0.05) and reduction of serum total cholesterol level in groups treated with
Kadukmy-1™.
Conclusions: The result of the present study revealed that Kadukmy™ exerts its antioxidant activity to reduce
oxidative stress damage, increase NO production and able to reduce blood pressure and cholesterol level. |
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