Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes

High dose atorvastatin is known to be associated with new onset diabetes mellitus (NODM) in patients with high risk for developing diabetes mellitus (DM). However, low dose atorvastatin is more commonly used as compared with high dose atorvastatin. The aim of this study is to investigate the impact...

Full description

Bibliographic Details
Main Authors:	Ji , Ji Young Park, Seung , Seung Woon Rha, Jae , Woong Choi, Sung , Kee Ryu, Seunghwan, Kim, Yung, Kyun Noh, Se , Yeon Choi, Raghavender , Goud Akkala, Hu, Li, Ali, Jabar, Shaopeng , Xu, Ngow, Harris Abdullah, Jae, Joong Lee, Gwang , No Lee, Jibak, Kim, Sunki , Lee, Jin , Oh Na, Cheol, Ung Choi, Hong, Euy Lim, Jin, Won Kim, Englu, Kim, Chang , Gyu Park, Hong, Seog Seo, Dong, Joo Oh
Format:	Article
Language:	English
Published:	Elsevier Ireland Ltd 2015
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/42707/ http://irep.iium.edu.my/42707/ http://irep.iium.edu.my/42707/ http://irep.iium.edu.my/42707/1/Impact_of_low_dose_atorvastatin_on_development_of_newonset_diabetes_mellitus_in_Asian_population._Three_year_clinical_outcomes.pdf

id	iium-42707
recordtype	eprints
spelling	iium-427072015-07-03T07:32:36Z http://irep.iium.edu.my/42707/ Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes Ji , Ji Young Park Seung , Seung Woon Rha Jae , Woong Choi Sung , Kee Ryu Seunghwan, Kim Yung, Kyun Noh Se , Yeon Choi Raghavender , Goud Akkala Hu, Li Ali, Jabar Shaopeng , Xu Ngow, Harris Abdullah Jae, Joong Lee Gwang , No Lee Jibak, Kim Sunki , Lee Jin , Oh Na Cheol, Ung Choi Hong, Euy Lim Jin, Won Kim Englu, Kim Chang , Gyu Park Hong, Seog Seo Dong, Joo Oh RC Internal medicine High dose atorvastatin is known to be associated with new onset diabetes mellitus (NODM) in patients with high risk for developing diabetes mellitus (DM). However, low dose atorvastatin is more commonly used as compared with high dose atorvastatin. The aim of this study is to investigate the impact of low dose atorvastatin (LDA, 10 mg or 20 mg) on the development of NODM up to three years in Asian patients. From January 2004 to September 2009, we investigated a total of 3566 patients who did not have DM. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM (C-statistics: 0.851), a total of 818 patients (LDA group, n = 409 patients and control group, n = 409 patients) were enrolled for analysis. Before PSM, the cumulative incidence of NODM (5.8% vs. 2.1%, p < 0.001), myocardial infarction (0.5% vs. 0.1%, p-value = 0.007), and major adverse cardio-cerebral event (MACCE, 1.8% vs. 0.7%, p-value = 0.012) at three-years were higher in the LAD group. However, after PSM, there was a trend toward higher incidence of NODM (5.9% vs. 3.2%, p = 0.064) in the LDA group, but the incidence of MACCE (1.2% vs. 1.5%, p-value = 1.000) was similar between the two groups. In multivariable analysis, the LDA administration was tended to be an independent predictor of NODM (OR: 1.99, 95% CI: 1.00–3.98, p-value 0.050). In this study, the use of LDA tended to be a risk factor for NODM in Asian patients and reduced clinical events similar to the control group. However, large-scale randomized controlled trials will be needed to get the final conclusion. Elsevier Ireland Ltd 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42707/1/Impact_of_low_dose_atorvastatin_on_development_of_newonset_diabetes_mellitus_in_Asian_population._Three_year_clinical_outcomes.pdf Ji , Ji Young Park and Seung , Seung Woon Rha and Jae , Woong Choi and Sung , Kee Ryu and Seunghwan, Kim and Yung, Kyun Noh and Se , Yeon Choi and Raghavender , Goud Akkala and Hu, Li and Ali, Jabar and Shaopeng , Xu and Ngow, Harris Abdullah and Jae, Joong Lee and Gwang , No Lee and Jibak, Kim and Sunki , Lee and Jin , Oh Na and Cheol, Ung Choi and Hong, Euy Lim and Jin, Won Kim and Englu, Kim and Chang , Gyu Park and Hong, Seog Seo and Dong, Joo Oh (2015) Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes. International Journal of Cardiology, 184. pp. 502-506. ISSN 0167-5273 http://www.sciencedirect.com/science/article/pii/S0167527315002855 10.1016/j.ijcard.2015.03.047
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Ji , Ji Young Park Seung , Seung Woon Rha Jae , Woong Choi Sung , Kee Ryu Seunghwan, Kim Yung, Kyun Noh Se , Yeon Choi Raghavender , Goud Akkala Hu, Li Ali, Jabar Shaopeng , Xu Ngow, Harris Abdullah Jae, Joong Lee Gwang , No Lee Jibak, Kim Sunki , Lee Jin , Oh Na Cheol, Ung Choi Hong, Euy Lim Jin, Won Kim Englu, Kim Chang , Gyu Park Hong, Seog Seo Dong, Joo Oh Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes
description	High dose atorvastatin is known to be associated with new onset diabetes mellitus (NODM) in patients with high risk for developing diabetes mellitus (DM). However, low dose atorvastatin is more commonly used as compared with high dose atorvastatin. The aim of this study is to investigate the impact of low dose atorvastatin (LDA, 10 mg or 20 mg) on the development of NODM up to three years in Asian patients. From January 2004 to September 2009, we investigated a total of 3566 patients who did not have DM. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM (C-statistics: 0.851), a total of 818 patients (LDA group, n = 409 patients and control group, n = 409 patients) were enrolled for analysis. Before PSM, the cumulative incidence of NODM (5.8% vs. 2.1%, p < 0.001), myocardial infarction (0.5% vs. 0.1%, p-value = 0.007), and major adverse cardio-cerebral event (MACCE, 1.8% vs. 0.7%, p-value = 0.012) at three-years were higher in the LAD group. However, after PSM, there was a trend toward higher incidence of NODM (5.9% vs. 3.2%, p = 0.064) in the LDA group, but the incidence of MACCE (1.2% vs. 1.5%, p-value = 1.000) was similar between the two groups. In multivariable analysis, the LDA administration was tended to be an independent predictor of NODM (OR: 1.99, 95% CI: 1.00–3.98, p-value 0.050). In this study, the use of LDA tended to be a risk factor for NODM in Asian patients and reduced clinical events similar to the control group. However, large-scale randomized controlled trials will be needed to get the final conclusion.
format	Article
author	Ji , Ji Young Park Seung , Seung Woon Rha Jae , Woong Choi Sung , Kee Ryu Seunghwan, Kim Yung, Kyun Noh Se , Yeon Choi Raghavender , Goud Akkala Hu, Li Ali, Jabar Shaopeng , Xu Ngow, Harris Abdullah Jae, Joong Lee Gwang , No Lee Jibak, Kim Sunki , Lee Jin , Oh Na Cheol, Ung Choi Hong, Euy Lim Jin, Won Kim Englu, Kim Chang , Gyu Park Hong, Seog Seo Dong, Joo Oh
author_facet	Ji , Ji Young Park Seung , Seung Woon Rha Jae , Woong Choi Sung , Kee Ryu Seunghwan, Kim Yung, Kyun Noh Se , Yeon Choi Raghavender , Goud Akkala Hu, Li Ali, Jabar Shaopeng , Xu Ngow, Harris Abdullah Jae, Joong Lee Gwang , No Lee Jibak, Kim Sunki , Lee Jin , Oh Na Cheol, Ung Choi Hong, Euy Lim Jin, Won Kim Englu, Kim Chang , Gyu Park Hong, Seog Seo Dong, Joo Oh
author_sort	Ji , Ji Young Park
title	Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes
title_short	Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes
title_full	Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes
title_fullStr	Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes
title_full_unstemmed	Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes
title_sort	impact of low dose atorvastatin on development of new-onset diabetes mellitus in asian population: three-year clinical outcomes
publisher	Elsevier Ireland Ltd
publishDate	2015
url	http://irep.iium.edu.my/42707/ http://irep.iium.edu.my/42707/ http://irep.iium.edu.my/42707/ http://irep.iium.edu.my/42707/1/Impact_of_low_dose_atorvastatin_on_development_of_newonset_diabetes_mellitus_in_Asian_population._Three_year_clinical_outcomes.pdf
first_indexed	2023-09-18T21:00:51Z
last_indexed	2023-09-18T21:00:51Z
_version_	1777410613219164160

Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes

Similar Items