Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens

Luvunga scandens species belongs to the family of Rutaceae. This plant usually inhabit tropical and moist environment and known as ‘Mengkurat Jakun’ among locals. A bioactivity-guided isolation and chemical investigation of the stem of Luvunga scandens resulted in the isolation and characterization...

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Main Authors:	Al-Zikri, Putri Nurhidayah, Bakhtiar, M. Taher, Darnis, Deny Susanti, Rezali, Mohd Fazlin, Read, Roger W, Sohrab, Md. Hossain, Hasan, Choudhury Mahmood, Ahmad, Farediah
Format:	Conference or Workshop Item
Language:	English English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/42493/ http://irep.iium.edu.my/42493/ http://irep.iium.edu.my/42493/1/42493.pdf http://irep.iium.edu.my/42493/2/Taher.pdf

id	iium-42493
recordtype	eprints
spelling	iium-424932016-05-23T07:01:12Z http://irep.iium.edu.my/42493/ Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens Al-Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah RS Pharmacy and materia medica Luvunga scandens species belongs to the family of Rutaceae. This plant usually inhabit tropical and moist environment and known as ‘Mengkurat Jakun’ among locals. A bioactivity-guided isolation and chemical investigation of the stem of Luvunga scandens resulted in the isolation and characterization of triterpenoids, 3-oxotirucalla-7,24-dien-21-oic-acid (1), and flindissol (2). The structures of the compound were determined on the basis of spectroscopic analyses including 2D NMR. The inhibitory effects of 1–2 on the proliferation on human breast adenocarcinoma cell line (MCF-7) have been evaluated by MTT assay and their effects on cell cycle and apoptosis investigated by flow cytometry with the morphological observation under Scanning Electron Microscope (SEM). Compounds 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 27.5 µM and 13.8 µM respectively. Flow cytometry investigations for 1–2 demonstrated that both compounds exert their anti-proliferative effect on MCF-7 cells through inhibiting cell cycle and inducing apoptosis. This result suggested that both compounds might be useful for anticancer agents. 2015-03 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/42493/1/42493.pdf application/pdf en http://irep.iium.edu.my/42493/2/Taher.pdf Al-Zikri, Putri Nurhidayah and Bakhtiar, M. Taher and Darnis, Deny Susanti and Rezali, Mohd Fazlin and Read, Roger W and Sohrab, Md. Hossain and Hasan, Choudhury Mahmood and Ahmad, Farediah (2015) Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens. In: International Conference on Natural Products 2015, 24-25 March 2015, Double Tree by Hilton, Johor Bahru. http://science.utm.my/icnp2015/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Al-Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens
description	Luvunga scandens species belongs to the family of Rutaceae. This plant usually inhabit tropical and moist environment and known as ‘Mengkurat Jakun’ among locals. A bioactivity-guided isolation and chemical investigation of the stem of Luvunga scandens resulted in the isolation and characterization of triterpenoids, 3-oxotirucalla-7,24-dien-21-oic-acid (1), and flindissol (2). The structures of the compound were determined on the basis of spectroscopic analyses including 2D NMR. The inhibitory effects of 1–2 on the proliferation on human breast adenocarcinoma cell line (MCF-7) have been evaluated by MTT assay and their effects on cell cycle and apoptosis investigated by flow cytometry with the morphological observation under Scanning Electron Microscope (SEM). Compounds 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 27.5 µM and 13.8 µM respectively. Flow cytometry investigations for 1–2 demonstrated that both compounds exert their anti-proliferative effect on MCF-7 cells through inhibiting cell cycle and inducing apoptosis. This result suggested that both compounds might be useful for anticancer agents.
format	Conference or Workshop Item
author	Al-Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah
author_facet	Al-Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah
author_sort	Al-Zikri, Putri Nurhidayah
title	Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens
title_short	Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens
title_full	Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens
title_fullStr	Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens
title_full_unstemmed	Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens
title_sort	bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens
publishDate	2015
url	http://irep.iium.edu.my/42493/ http://irep.iium.edu.my/42493/ http://irep.iium.edu.my/42493/1/42493.pdf http://irep.iium.edu.my/42493/2/Taher.pdf
first_indexed	2023-09-18T21:00:35Z
last_indexed	2023-09-18T21:00:35Z
_version_	1777410596279418880

Bioguided isolation of cytotoxic triterpenoids from the stem of luvunga scandens

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