In vitro wound healing activity of sapium indicum willd leaf extracts

Background: Sapium indicum Willd (Euphorbiaceae) is traditionally used to accelerate wound healing process in Malay community. Objective: To evaluate wound healing potential of aqueous (AESI) and ethanolic extract of S. indicum leaves (EESI) using cell migration model. Methods: AESI and EESI were...

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Main Authors:	Abdul Aziz, Huwaida, Bakhtiar, M. Taher, Darnis, Deny Susanti, Zakaria, Zainul Amiruddin
Format:	Article
Language:	English English
Published:	African Ethnomedicines Network 2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/42490/ http://irep.iium.edu.my/42490/ http://irep.iium.edu.my/42490/ http://irep.iium.edu.my/42490/1/Huwaida_wound_healing.pdf http://irep.iium.edu.my/42490/4/42490__WOS_and_SCOPUS.pdf

id	iium-42490
recordtype	eprints
spelling	iium-424902016-05-16T02:30:07Z http://irep.iium.edu.my/42490/ In vitro wound healing activity of sapium indicum willd leaf extracts Abdul Aziz, Huwaida Bakhtiar, M. Taher Darnis, Deny Susanti Zakaria, Zainul Amiruddin RS Pharmacy and materia medica Background: Sapium indicum Willd (Euphorbiaceae) is traditionally used to accelerate wound healing process in Malay community. Objective: To evaluate wound healing potential of aqueous (AESI) and ethanolic extract of S. indicum leaves (EESI) using cell migration model. Methods: AESI and EESI were prepared using maceration techniques. The extracts were subjected to phytochemical screening, cytotoxicity (MTT assay) and scratch assay. Results: AESI contained saponins and tannins while EESI contained triterpenes, tannins and proteins. Based on MTT assay, AESI and EESI exhibited IC50 = 16.3 and 70.9 μg/mL, respectively. In the scratch assay, EESI caused significant (P< 0.05) concentration-dependent migration on 3T3 L1 cells whereas AESI exerted concentration-independent effect. Conclusion: The leaves of S. indicum exhibited wound healing potential and contained phytochemicals that may contribute to the activity. These findings would support potential use of S. indicum as wound healing plant. African Ethnomedicines Network 2015-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42490/1/Huwaida_wound_healing.pdf application/pdf en http://irep.iium.edu.my/42490/4/42490__WOS_and_SCOPUS.pdf Abdul Aziz, Huwaida and Bakhtiar, M. Taher and Darnis, Deny Susanti and Zakaria, Zainul Amiruddin (2015) In vitro wound healing activity of sapium indicum willd leaf extracts. African Journal of Traditional, Complementary and Alternative Medicines, 12 (2). pp. 126-132. ISSN 0189-6016 http://journals.sfu.ca/africanem/index.php/ajtcam/index http://dx.doi.org/10.4314/ajtcam.v12i2.19
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abdul Aziz, Huwaida Bakhtiar, M. Taher Darnis, Deny Susanti Zakaria, Zainul Amiruddin In vitro wound healing activity of sapium indicum willd leaf extracts
description	Background: Sapium indicum Willd (Euphorbiaceae) is traditionally used to accelerate wound healing process in Malay community. Objective: To evaluate wound healing potential of aqueous (AESI) and ethanolic extract of S. indicum leaves (EESI) using cell migration model. Methods: AESI and EESI were prepared using maceration techniques. The extracts were subjected to phytochemical screening, cytotoxicity (MTT assay) and scratch assay. Results: AESI contained saponins and tannins while EESI contained triterpenes, tannins and proteins. Based on MTT assay, AESI and EESI exhibited IC50 = 16.3 and 70.9 μg/mL, respectively. In the scratch assay, EESI caused significant (P< 0.05) concentration-dependent migration on 3T3 L1 cells whereas AESI exerted concentration-independent effect. Conclusion: The leaves of S. indicum exhibited wound healing potential and contained phytochemicals that may contribute to the activity. These findings would support potential use of S. indicum as wound healing plant.
format	Article
author	Abdul Aziz, Huwaida Bakhtiar, M. Taher Darnis, Deny Susanti Zakaria, Zainul Amiruddin
author_facet	Abdul Aziz, Huwaida Bakhtiar, M. Taher Darnis, Deny Susanti Zakaria, Zainul Amiruddin
author_sort	Abdul Aziz, Huwaida
title	In vitro wound healing activity of sapium indicum willd leaf extracts
title_short	In vitro wound healing activity of sapium indicum willd leaf extracts
title_full	In vitro wound healing activity of sapium indicum willd leaf extracts
title_fullStr	In vitro wound healing activity of sapium indicum willd leaf extracts
title_full_unstemmed	In vitro wound healing activity of sapium indicum willd leaf extracts
title_sort	in vitro wound healing activity of sapium indicum willd leaf extracts
publisher	African Ethnomedicines Network
publishDate	2015
url	http://irep.iium.edu.my/42490/ http://irep.iium.edu.my/42490/ http://irep.iium.edu.my/42490/ http://irep.iium.edu.my/42490/1/Huwaida_wound_healing.pdf http://irep.iium.edu.my/42490/4/42490__WOS_and_SCOPUS.pdf
first_indexed	2023-09-18T21:00:35Z
last_indexed	2023-09-18T21:00:35Z
_version_	1777410595977428992

In vitro wound healing activity of sapium indicum willd leaf extracts

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