Effects of process parameters on spray drying of recombinant bromelain

Bromelain is a plant protease with diverse industrial, analytical and pharmacological uses. This research work is aimed at evaluating the effects of some process parameters (inlet temperature, pump and aspirator settings) on spray drying of recombinant bromelain using full factorial design of experi...

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Main Authors:	Muntari, Bala, Amid, Azura, Jami, Mohammed Saedi, Mel, Maizirwan, Mohd. Salleh, Hamzah
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/42415/ http://irep.iium.edu.my/42415/ http://irep.iium.edu.my/42415/1/ICBIOE_Bala_cover.pdf

id	iium-42415
recordtype	eprints
spelling	iium-424152015-04-27T02:01:14Z http://irep.iium.edu.my/42415/ Effects of process parameters on spray drying of recombinant bromelain Muntari, Bala Amid, Azura Jami, Mohammed Saedi Mel, Maizirwan Mohd. Salleh, Hamzah TP248.13 Biotechnology Bromelain is a plant protease with diverse industrial, analytical and pharmacological uses. This research work is aimed at evaluating the effects of some process parameters (inlet temperature, pump and aspirator settings) on spray drying of recombinant bromelain using full factorial design of experiments. The experiments were conducted in Buchi B-290 mini spray dryer using maltodextrin as carrier agent. The results obtained revealed that the interaction and linear coefficients wer e statistically significant coupled with existence of good conformity between the experimental and the theoretical values predicted by the model. The precise optimum conditions obtained (aspirator setting, 90 (%); inlet temperature, 110 ºC; and pump setting, 12.5 %) generated the maximum activity of 78.08±0.07 U/ml (equivalent to residual activity of about 92.64±0.09) for the spray dried recombinant bromelain. This implies that the study has effectively produced viable and well formulated spray dried recombinant bromelain under optimized conditions. 2013 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/42415/1/ICBIOE_Bala_cover.pdf Muntari, Bala and Amid, Azura and Jami, Mohammed Saedi and Mel, Maizirwan and Mohd. Salleh, Hamzah (2013) Effects of process parameters on spray drying of recombinant bromelain. In: 3rd International Conference on Biotechnology Engineering (ICBIoE 2013), 2-4 July 2013, Kuala Lumpur, Malaysia. http://www.iium.edu.my/icbioe/2013/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Muntari, Bala Amid, Azura Jami, Mohammed Saedi Mel, Maizirwan Mohd. Salleh, Hamzah Effects of process parameters on spray drying of recombinant bromelain
description	Bromelain is a plant protease with diverse industrial, analytical and pharmacological uses. This research work is aimed at evaluating the effects of some process parameters (inlet temperature, pump and aspirator settings) on spray drying of recombinant bromelain using full factorial design of experiments. The experiments were conducted in Buchi B-290 mini spray dryer using maltodextrin as carrier agent. The results obtained revealed that the interaction and linear coefficients wer e statistically significant coupled with existence of good conformity between the experimental and the theoretical values predicted by the model. The precise optimum conditions obtained (aspirator setting, 90 (%); inlet temperature, 110 ºC; and pump setting, 12.5 %) generated the maximum activity of 78.08±0.07 U/ml (equivalent to residual activity of about 92.64±0.09) for the spray dried recombinant bromelain. This implies that the study has effectively produced viable and well formulated spray dried recombinant bromelain under optimized conditions.
format	Conference or Workshop Item
author	Muntari, Bala Amid, Azura Jami, Mohammed Saedi Mel, Maizirwan Mohd. Salleh, Hamzah
author_facet	Muntari, Bala Amid, Azura Jami, Mohammed Saedi Mel, Maizirwan Mohd. Salleh, Hamzah
author_sort	Muntari, Bala
title	Effects of process parameters on spray drying of recombinant bromelain
title_short	Effects of process parameters on spray drying of recombinant bromelain
title_full	Effects of process parameters on spray drying of recombinant bromelain
title_fullStr	Effects of process parameters on spray drying of recombinant bromelain
title_full_unstemmed	Effects of process parameters on spray drying of recombinant bromelain
title_sort	effects of process parameters on spray drying of recombinant bromelain
publishDate	2013
url	http://irep.iium.edu.my/42415/ http://irep.iium.edu.my/42415/ http://irep.iium.edu.my/42415/1/ICBIOE_Bala_cover.pdf
first_indexed	2023-09-18T21:00:28Z
last_indexed	2023-09-18T21:00:28Z
_version_	1777410588627959808

Effects of process parameters on spray drying of recombinant bromelain

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