Do Asian women have endometrial cancer at a younger age?

The purpose of this study is to examine the epidemiological and clinical characteristics of patients with endometrial adenocarcinoma. This is a retrospective observational study of all cases of endometrial adenocarcinoma managed in Hospital Tengku Ampuan Afzan, from January 2011 until December 2013....

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Main Authors:	Awang, Mokhtar, Zakaria, Abdul Razak, Ong, N., Mat Ali, N., Roslani, A. L., Ismail, R.
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/42331/ http://irep.iium.edu.my/42331/ http://irep.iium.edu.my/42331/4/ESGO_State_of_the_Art_Conference_2014.pdf http://irep.iium.edu.my/42331/3/ESGO_Epideomiological_and_Clinical_Characteristics.doc

id	iium-42331
recordtype	eprints
spelling	iium-423312018-06-19T01:35:41Z http://irep.iium.edu.my/42331/ Do Asian women have endometrial cancer at a younger age? Awang, Mokhtar Zakaria, Abdul Razak Ong, N. Mat Ali, N. Roslani, A. L. Ismail, R. RG Gynecology and obstetrics The purpose of this study is to examine the epidemiological and clinical characteristics of patients with endometrial adenocarcinoma. This is a retrospective observational study of all cases of endometrial adenocarcinoma managed in Hospital Tengku Ampuan Afzan, from January 2011 until December 2013. During this study period there were 48 cases of endometrial adenocarcinoma. The mean age at diagnosis was 53.5  10.5 year-old (range 30-79). One-fifth of these patients were 45 years and younger. The mean parity was 2.5  2.5. The majority (80%) were obese with a mean BMI of 28.8  5.9. The prevalence of diabetes, hypertension and polycystic ovarian disease were only 30%, 25% and 15% respectively. A significant proportion of women (40%) were in their premenopausal period. The remaining (60%) were in their peri/postmenopausal period. All the patients presented with abnormal uterine bleeding with a mean endometrial thickness of 22.7  13.9mm. Equal numbers of women had office endometrial sampling and hysteroscopy and dilatation and curettage as a primary endometrial assessment. In this study, we found that the positive predictive value (PPV) of office endometrial sampling is 76.0%. The majority of the endometrial carcinoma was of endometriod type (81.3%) and the others were high-grade endometrial carcinoma (4.2%), clear cell adenocarcinoma (4.2%), papillary serous (2.1%) and others (8.3%). The PPV of histological grade obtained via office endometrial sampling for grade 1, grade 2 and grade 3 in comparison to the full histology was 81.8%, 58.8% and 60.0% respectively. However, the differences observed in the PPV for different histological grading did not reach statistical significance (p=0.185). In this study, the majority of patients (66.7%) had stage 1 disease followed by stage 3 (23.0%) at diagnosis. Small percentages of women had stage 2 and stage 4 disease at diagnosis i.e. 6.3% and 4.2% respectively. The majority of patients, 58.3% required further adjuvant treatment while the remaining 41.7% did not need further treatment. The mean age of diagnosis of endometrial cancer in our studied population is about ten years younger compared to Western populations. The percentage of Asian women 45 years and younger diagnosed with endometrial carcinoma was alarmingly high i.e. 4 fold higher compared to Caucasian women. Thus we recommend a lower age threshold for proper evaluation of Asian women presenting with abnormal uterine bleeding i.e. 35 years instead of 45 years as recommended by most cancer centres in the west. 2014-09 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/42331/4/ESGO_State_of_the_Art_Conference_2014.pdf application/pdf en http://irep.iium.edu.my/42331/3/ESGO_Epideomiological_and_Clinical_Characteristics.doc Awang, Mokhtar and Zakaria, Abdul Razak and Ong, N. and Mat Ali, N. and Roslani, A. L. and Ismail, R. (2014) Do Asian women have endometrial cancer at a younger age? In: ESGO,State of the Art Conference 2014, Follow up in Gynaecological Malignancy, 11-13 Sep 2014, Torino, Italy. (Unpublished) http://torino2014.esgo.org/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Awang, Mokhtar Zakaria, Abdul Razak Ong, N. Mat Ali, N. Roslani, A. L. Ismail, R. Do Asian women have endometrial cancer at a younger age?
description	The purpose of this study is to examine the epidemiological and clinical characteristics of patients with endometrial adenocarcinoma. This is a retrospective observational study of all cases of endometrial adenocarcinoma managed in Hospital Tengku Ampuan Afzan, from January 2011 until December 2013. During this study period there were 48 cases of endometrial adenocarcinoma. The mean age at diagnosis was 53.5  10.5 year-old (range 30-79). One-fifth of these patients were 45 years and younger. The mean parity was 2.5  2.5. The majority (80%) were obese with a mean BMI of 28.8  5.9. The prevalence of diabetes, hypertension and polycystic ovarian disease were only 30%, 25% and 15% respectively. A significant proportion of women (40%) were in their premenopausal period. The remaining (60%) were in their peri/postmenopausal period. All the patients presented with abnormal uterine bleeding with a mean endometrial thickness of 22.7  13.9mm. Equal numbers of women had office endometrial sampling and hysteroscopy and dilatation and curettage as a primary endometrial assessment. In this study, we found that the positive predictive value (PPV) of office endometrial sampling is 76.0%. The majority of the endometrial carcinoma was of endometriod type (81.3%) and the others were high-grade endometrial carcinoma (4.2%), clear cell adenocarcinoma (4.2%), papillary serous (2.1%) and others (8.3%). The PPV of histological grade obtained via office endometrial sampling for grade 1, grade 2 and grade 3 in comparison to the full histology was 81.8%, 58.8% and 60.0% respectively. However, the differences observed in the PPV for different histological grading did not reach statistical significance (p=0.185). In this study, the majority of patients (66.7%) had stage 1 disease followed by stage 3 (23.0%) at diagnosis. Small percentages of women had stage 2 and stage 4 disease at diagnosis i.e. 6.3% and 4.2% respectively. The majority of patients, 58.3% required further adjuvant treatment while the remaining 41.7% did not need further treatment. The mean age of diagnosis of endometrial cancer in our studied population is about ten years younger compared to Western populations. The percentage of Asian women 45 years and younger diagnosed with endometrial carcinoma was alarmingly high i.e. 4 fold higher compared to Caucasian women. Thus we recommend a lower age threshold for proper evaluation of Asian women presenting with abnormal uterine bleeding i.e. 35 years instead of 45 years as recommended by most cancer centres in the west.
format	Conference or Workshop Item
author	Awang, Mokhtar Zakaria, Abdul Razak Ong, N. Mat Ali, N. Roslani, A. L. Ismail, R.
author_facet	Awang, Mokhtar Zakaria, Abdul Razak Ong, N. Mat Ali, N. Roslani, A. L. Ismail, R.
author_sort	Awang, Mokhtar
title	Do Asian women have endometrial cancer at a younger age?
title_short	Do Asian women have endometrial cancer at a younger age?
title_full	Do Asian women have endometrial cancer at a younger age?
title_fullStr	Do Asian women have endometrial cancer at a younger age?
title_full_unstemmed	Do Asian women have endometrial cancer at a younger age?
title_sort	do asian women have endometrial cancer at a younger age?
publishDate	2014
url	http://irep.iium.edu.my/42331/ http://irep.iium.edu.my/42331/ http://irep.iium.edu.my/42331/4/ESGO_State_of_the_Art_Conference_2014.pdf http://irep.iium.edu.my/42331/3/ESGO_Epideomiological_and_Clinical_Characteristics.doc
first_indexed	2023-09-18T21:00:21Z
last_indexed	2023-09-18T21:00:21Z
_version_	1777410581887713280

Do Asian women have endometrial cancer at a younger age?

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