Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor

The production of monoclonal antibody (IgM) for anti-cancer by fermentation of hybridoma cell in benchtop bioreactor has been investigated. The main target of this study was to increase the percentage of cell viability and to achieve high yield of IgM. There are many ways that can be applied to impr...

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Main Authors:	Mel, Maizirwan, Arifin, Mohd Azmir, Abdul Karim, Mohamed Ismail, Yusof, Faridah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	TP155 Chemical engineering TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/4232/ http://irep.iium.edu.my/4232/1/Paper_SCP.pdf

id	iium-4232
recordtype	eprints
spelling	iium-42322011-10-05T06:42:11Z http://irep.iium.edu.my/4232/ Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor Mel, Maizirwan Arifin, Mohd Azmir Abdul Karim, Mohamed Ismail Yusof, Faridah TP155 Chemical engineering TP248.13 Biotechnology The production of monoclonal antibody (IgM) for anti-cancer by fermentation of hybridoma cell in benchtop bioreactor has been investigated. The main target of this study was to increase the percentage of cell viability and to achieve high yield of IgM. There are many ways that can be applied to improve the process and one of them is by choosing the correct Six Sigma’s Design of Experiment (DOE). In this study, Taguchi’s Experimental Design has been applied to achieve high percentage of cell viability in the fermentation experiment. The process capability of this study was later analyzed by using the MiniTab Software (Ver. 14). Analysis has shown that this study has fulfilled a minimum target of process improvement as indicated by the Cp and Cpk value of 0.90 and 0.86. This proved that the fermentation experiment has achieved cell viability of more than 80% throughout the study. 2011 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/4232/1/Paper_SCP.pdf Mel, Maizirwan and Arifin, Mohd Azmir and Abdul Karim, Mohamed Ismail and Yusof, Faridah (2011) Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor. In: 2nd International Conference on Biotechnology Engineering (ICBioE 2011), 17-19 May 2011, The Legend Hotel, Kuala Lumpur.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP155 Chemical engineering TP248.13 Biotechnology
spellingShingle	TP155 Chemical engineering TP248.13 Biotechnology Mel, Maizirwan Arifin, Mohd Azmir Abdul Karim, Mohamed Ismail Yusof, Faridah Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor
description	The production of monoclonal antibody (IgM) for anti-cancer by fermentation of hybridoma cell in benchtop bioreactor has been investigated. The main target of this study was to increase the percentage of cell viability and to achieve high yield of IgM. There are many ways that can be applied to improve the process and one of them is by choosing the correct Six Sigma’s Design of Experiment (DOE). In this study, Taguchi’s Experimental Design has been applied to achieve high percentage of cell viability in the fermentation experiment. The process capability of this study was later analyzed by using the MiniTab Software (Ver. 14). Analysis has shown that this study has fulfilled a minimum target of process improvement as indicated by the Cp and Cpk value of 0.90 and 0.86. This proved that the fermentation experiment has achieved cell viability of more than 80% throughout the study.
format	Conference or Workshop Item
author	Mel, Maizirwan Arifin, Mohd Azmir Abdul Karim, Mohamed Ismail Yusof, Faridah
author_facet	Mel, Maizirwan Arifin, Mohd Azmir Abdul Karim, Mohamed Ismail Yusof, Faridah
author_sort	Mel, Maizirwan
title	Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor
title_short	Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor
title_full	Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor
title_fullStr	Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor
title_full_unstemmed	Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor
title_sort	simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor
publishDate	2011
url	http://irep.iium.edu.my/4232/ http://irep.iium.edu.my/4232/1/Paper_SCP.pdf
first_indexed	2023-09-18T20:12:22Z
last_indexed	2023-09-18T20:12:22Z
_version_	1777407563320524800

Simple process capability analysis and quality validation of monoclonal antibody production in bench-top bioreactor

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