Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia

Even though the role of the DICS1 gene as a risk factor for schizophrenia is still unclear, there is substantial evidence from functional and cell biology studies that supports the connection of the gene with schizophrenia. The studies associating the DISC1 gene with schizophrenia in Asian populatio...

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Main Authors:	A. Talib, Norlelawati, Abdullah, Kartini, Ku Zaifah, Norsidah, Musa, Ramli, Abdul Razak, Tariq, Wan Rohani, Wan Taib
Format:	Article
Language:	English
Published:	Korean Neuropsychiatric Association 2015
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/42198/ http://irep.iium.edu.my/42198/ http://irep.iium.edu.my/42198/ http://irep.iium.edu.my/42198/1/Disrupted_in_Sz_Evidence_fr_Malaysia_2015.pdf

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spelling	iium-421982018-02-26T10:16:05Z http://irep.iium.edu.my/42198/ Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia A. Talib, Norlelawati Abdullah, Kartini Ku Zaifah, Norsidah Musa, Ramli Abdul Razak, Tariq Wan Rohani, Wan Taib R Medicine (General) Even though the role of the DICS1 gene as a risk factor for schizophrenia is still unclear, there is substantial evidence from functional and cell biology studies that supports the connection of the gene with schizophrenia. The studies associating the DISC1 gene with schizophrenia in Asian populations are limited to East-Asian populations. Our study examined several DISC1 markers of schizophrenia that were identified in the Caucasian and East-Asian populations in Malaysia and assessed the role of rs2509382, which is located at 11q14.3, the mutual translocation region of the famous DISC1 translocation [t (1; 11) (p42.1; q14.3)]. METHODS: We genotyped eleven single-neucleotide polymorphism (SNPs) within or related to DISC1 (rs821597, rs821616, rs4658971, rs1538979, rs843979, rs2812385, rs1407599, rs4658890, and rs2509382) using the PCR-RFLP methods. RESULTS: In all, there were 575 participants (225 schizophrenic patients and 350 healthy controls) of either Malay or Chinese ethnicity. The case-control analyses found two SNPs that were associated with schizophrenia [rs4658971 (p=0.030; OR=1.43 (1.35-1.99) and rs1538979-(p=0.036; OR=1.35 (1.02-1.80)] and rs2509382-susceptibility among the males schizophrenics [p=0.0082; OR=2.16 (1.22-3.81)]. This is similar to the meta-analysis findings for the Caucasian populations. CONCLUSION: The study supports the notion that the DISC1 gene is a marker of schizophrenia susceptibility and that rs2509382 in the mutual DISC1 translocation region is a susceptibility marker for schizophrenia among males in Malaysia. However, the finding of the study is limited due to possible genetic stratification and the small sample size. KEYWORDS: DISC1; SNPs; Schizophrenia; Susceptibility Korean Neuropsychiatric Association 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42198/1/Disrupted_in_Sz_Evidence_fr_Malaysia_2015.pdf A. Talib, Norlelawati and Abdullah, Kartini and Ku Zaifah, Norsidah and Musa, Ramli and Abdul Razak, Tariq and Wan Rohani, Wan Taib (2015) Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia. Psychiatry Investigation, 12 (1). pp. 103-111. ISSN 1738-3684 (P) 1976-3026 (O) http://synapse.koreamed.org/DOIx.php?id=10.4306/pi.2015.12.1.103 10.4306/pi.2015.12.1.103
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) A. Talib, Norlelawati Abdullah, Kartini Ku Zaifah, Norsidah Musa, Ramli Abdul Razak, Tariq Wan Rohani, Wan Taib Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia
description	Even though the role of the DICS1 gene as a risk factor for schizophrenia is still unclear, there is substantial evidence from functional and cell biology studies that supports the connection of the gene with schizophrenia. The studies associating the DISC1 gene with schizophrenia in Asian populations are limited to East-Asian populations. Our study examined several DISC1 markers of schizophrenia that were identified in the Caucasian and East-Asian populations in Malaysia and assessed the role of rs2509382, which is located at 11q14.3, the mutual translocation region of the famous DISC1 translocation [t (1; 11) (p42.1; q14.3)]. METHODS: We genotyped eleven single-neucleotide polymorphism (SNPs) within or related to DISC1 (rs821597, rs821616, rs4658971, rs1538979, rs843979, rs2812385, rs1407599, rs4658890, and rs2509382) using the PCR-RFLP methods. RESULTS: In all, there were 575 participants (225 schizophrenic patients and 350 healthy controls) of either Malay or Chinese ethnicity. The case-control analyses found two SNPs that were associated with schizophrenia [rs4658971 (p=0.030; OR=1.43 (1.35-1.99) and rs1538979-(p=0.036; OR=1.35 (1.02-1.80)] and rs2509382-susceptibility among the males schizophrenics [p=0.0082; OR=2.16 (1.22-3.81)]. This is similar to the meta-analysis findings for the Caucasian populations. CONCLUSION: The study supports the notion that the DISC1 gene is a marker of schizophrenia susceptibility and that rs2509382 in the mutual DISC1 translocation region is a susceptibility marker for schizophrenia among males in Malaysia. However, the finding of the study is limited due to possible genetic stratification and the small sample size. KEYWORDS: DISC1; SNPs; Schizophrenia; Susceptibility
format	Article
author	A. Talib, Norlelawati Abdullah, Kartini Ku Zaifah, Norsidah Musa, Ramli Abdul Razak, Tariq Wan Rohani, Wan Taib
author_facet	A. Talib, Norlelawati Abdullah, Kartini Ku Zaifah, Norsidah Musa, Ramli Abdul Razak, Tariq Wan Rohani, Wan Taib
author_sort	A. Talib, Norlelawati
title	Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia
title_short	Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia
title_full	Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia
title_fullStr	Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia
title_full_unstemmed	Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia
title_sort	disrupted-in-schizophrenia-1 snps and susceptibility to schizophrenia: evidence from malaysia
publisher	Korean Neuropsychiatric Association
publishDate	2015
url	http://irep.iium.edu.my/42198/ http://irep.iium.edu.my/42198/ http://irep.iium.edu.my/42198/ http://irep.iium.edu.my/42198/1/Disrupted_in_Sz_Evidence_fr_Malaysia_2015.pdf
first_indexed	2023-09-18T21:00:12Z
last_indexed	2023-09-18T21:00:12Z
_version_	1777410572728401920

Disrupted-in-schizophrenia-1 SNPs and susceptibility to schizophrenia: evidence from Malaysia

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