Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases

Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging...

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Main Authors:	Lestari, Widya, Jaswir, Irwandi, Nordin, Nur Sazwi, Octavianti, Fitri, Nagao, Akihiko
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/42170/ http://irep.iium.edu.my/42170/11/42170-certificate.pdf http://irep.iium.edu.my/42170/13/42170_poster.pdf

id	iium-42170
recordtype	eprints
spelling	iium-421702016-08-03T08:37:25Z http://irep.iium.edu.my/42170/ Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko RK Dentistry Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging DNA. Epidemiological evidences have suggested that intake of fruits and vegetables reduces the risk of both cancer and cardiovascular disease. Flavonoids, carotenoids, vitamin C, vitamin E and selenium are the major dietary antioxidants. Several large intervention studies have thus been conducted with beta-carotene and vitamin E, leading investigations on chemoprevention of chronic diseases with dietary antioxidants. However, beta-carotene supplementation has shown not only positive but also negative effects on human health. The antioxidant activity of these compounds may shift into prooxidant activity, depending on the redox potential of the carotenoid molecules as well as on the biological environment in which they act. The prooxidant potency of these compounds is determined by several factors, including oxygen tension, carotenoid concentration, and interactions with other antioxidants. Prooxidant activity can induce harmful results in biologic systems and influence the development of human chronic diseases. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/42170/11/42170-certificate.pdf application/pdf en http://irep.iium.edu.my/42170/13/42170_poster.pdf Lestari, Widya and Jaswir, Irwandi and Nordin, Nur Sazwi and Octavianti, Fitri and Nagao, Akihiko (2014) Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases. In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014), 11th -13th June 2014, Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RK Dentistry
spellingShingle	RK Dentistry Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
description	Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging DNA. Epidemiological evidences have suggested that intake of fruits and vegetables reduces the risk of both cancer and cardiovascular disease. Flavonoids, carotenoids, vitamin C, vitamin E and selenium are the major dietary antioxidants. Several large intervention studies have thus been conducted with beta-carotene and vitamin E, leading investigations on chemoprevention of chronic diseases with dietary antioxidants. However, beta-carotene supplementation has shown not only positive but also negative effects on human health. The antioxidant activity of these compounds may shift into prooxidant activity, depending on the redox potential of the carotenoid molecules as well as on the biological environment in which they act. The prooxidant potency of these compounds is determined by several factors, including oxygen tension, carotenoid concentration, and interactions with other antioxidants. Prooxidant activity can induce harmful results in biologic systems and influence the development of human chronic diseases.
format	Conference or Workshop Item
author	Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko
author_facet	Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko
author_sort	Lestari, Widya
title	Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_short	Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_full	Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_fullStr	Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_full_unstemmed	Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_sort	dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
publishDate	2014
url	http://irep.iium.edu.my/42170/ http://irep.iium.edu.my/42170/11/42170-certificate.pdf http://irep.iium.edu.my/42170/13/42170_poster.pdf
first_indexed	2023-09-18T21:00:10Z
last_indexed	2023-09-18T21:00:10Z
_version_	1777410570275782656

Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases

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