Apolipoprotein E gene polymorphism in hypertension

Essential hypertension is a common multifactorial disease of the cardiovascular system with significant morbidity and mortality (Trenk et al .,1999 ). It is believed that essential hypertension is caused by complex interactions between multiple environmental and genetic factors. Even though much is...

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Main Authors:	Ibrahim, Wisam Nabeel, A.Talib, Norlelawati, Abdullah, Nor Zamzila, Aung, Nilar, Ku Zaifah, Norsidah
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/41525/ http://irep.iium.edu.my/41525/1/41525.pdf

id	iium-41525
recordtype	eprints
spelling	iium-415252015-04-28T01:33:52Z http://irep.iium.edu.my/41525/ Apolipoprotein E gene polymorphism in hypertension Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Nilar Ku Zaifah, Norsidah QP Physiology Essential hypertension is a common multifactorial disease of the cardiovascular system with significant morbidity and mortality (Trenk et al .,1999 ). It is believed that essential hypertension is caused by complex interactions between multiple environmental and genetic factors. Even though much is known about the environmental factors such as salt intake and exercise, but on the other hand the genetic factors that predispose individuals to hypertension are still poorly understood. It is also very clear from literatures that oxidative stress, atherosclerosis and endothelial dysfunction play an important role in the pathogenesis of experimental and human hypertension (Touyz et al., 2004). Apo lipoprotein E (Apo E) is a plasma protein which has shown a powerful antioxidant, anti atherosclerotic and endothelial protective properties that might protect from initiation and progression of hypertension. Apo E is synthesized mainly by the liver. It is the critical ligand in the plasma clearance of triglyceride and cholesterol-rich lipoproteins (chylomicron remnants, VLDL, intermediate density lipoproteins and LDL), (Mahley et al., 2000). The biological function of Apo E is highly effected by the polymorphism in its gene which is located on chromosome 19 and it’s polymorphism results in three common alleles of protein (Ԑ2, Ԑ3 and Ԑ4) (Mahley et al., 2011) . In which the Ԑ3 allele is the normal functional form while the Ԑ2 and Ԑ4 alleles are the dysfunctional forms which are associated with increased risk for atherosclerosis & oxidative stress (Mahley et al., 2011). 2013 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/41525/1/41525.pdf Ibrahim, Wisam Nabeel and A.Talib, Norlelawati and Abdullah, Nor Zamzila and Aung, Nilar and Ku Zaifah, Norsidah (2013) Apolipoprotein E gene polymorphism in hypertension. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2013, 19-20th February 2013, Cultural Activity Centre (CAC) and KAED Gallery, IIUM.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology
spellingShingle	QP Physiology Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Nilar Ku Zaifah, Norsidah Apolipoprotein E gene polymorphism in hypertension
description	Essential hypertension is a common multifactorial disease of the cardiovascular system with significant morbidity and mortality (Trenk et al .,1999 ). It is believed that essential hypertension is caused by complex interactions between multiple environmental and genetic factors. Even though much is known about the environmental factors such as salt intake and exercise, but on the other hand the genetic factors that predispose individuals to hypertension are still poorly understood. It is also very clear from literatures that oxidative stress, atherosclerosis and endothelial dysfunction play an important role in the pathogenesis of experimental and human hypertension (Touyz et al., 2004). Apo lipoprotein E (Apo E) is a plasma protein which has shown a powerful antioxidant, anti atherosclerotic and endothelial protective properties that might protect from initiation and progression of hypertension. Apo E is synthesized mainly by the liver. It is the critical ligand in the plasma clearance of triglyceride and cholesterol-rich lipoproteins (chylomicron remnants, VLDL, intermediate density lipoproteins and LDL), (Mahley et al., 2000). The biological function of Apo E is highly effected by the polymorphism in its gene which is located on chromosome 19 and it’s polymorphism results in three common alleles of protein (Ԑ2, Ԑ3 and Ԑ4) (Mahley et al., 2011) . In which the Ԑ3 allele is the normal functional form while the Ԑ2 and Ԑ4 alleles are the dysfunctional forms which are associated with increased risk for atherosclerosis & oxidative stress (Mahley et al., 2011).
format	Conference or Workshop Item
author	Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Nilar Ku Zaifah, Norsidah
author_facet	Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Nilar Ku Zaifah, Norsidah
author_sort	Ibrahim, Wisam Nabeel
title	Apolipoprotein E gene polymorphism in hypertension
title_short	Apolipoprotein E gene polymorphism in hypertension
title_full	Apolipoprotein E gene polymorphism in hypertension
title_fullStr	Apolipoprotein E gene polymorphism in hypertension
title_full_unstemmed	Apolipoprotein E gene polymorphism in hypertension
title_sort	apolipoprotein e gene polymorphism in hypertension
publishDate	2013
url	http://irep.iium.edu.my/41525/ http://irep.iium.edu.my/41525/1/41525.pdf
first_indexed	2023-09-18T20:59:27Z
last_indexed	2023-09-18T20:59:27Z
_version_	1777410525223714816

Apolipoprotein E gene polymorphism in hypertension

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