A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases

Coronary artery disease (CAD) is a common disease with significantly high morbidity and mortality (Libby et al., 1998). It is also one of the leading causes of death worldwide. In 2012, it was stated that CAD participates in over 30% of Malaysian adult mortality rate (Malaysian death profile, 2013)....

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Main Authors:	Ibrahim, Wisam Nabeel, A.Talib, Norlelawati, Abdullah, Nor Zamzila
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/41513/ http://irep.iium.edu.my/41513/2/A_STUDY_ON_ANGIO.pdf http://irep.iium.edu.my/41513/3/72_%281%29.pdf

id	iium-41513
recordtype	eprints
spelling	iium-415132018-05-05T17:50:24Z http://irep.iium.edu.my/41513/ A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila QP Physiology Coronary artery disease (CAD) is a common disease with significantly high morbidity and mortality (Libby et al., 1998). It is also one of the leading causes of death worldwide. In 2012, it was stated that CAD participates in over 30% of Malaysian adult mortality rate (Malaysian death profile, 2013). CAD occurs from complex interactions between variety of environmental and genetic factors. Smoking, alcoholism, and sedentary lifestyle are believed to be the commonest environmental predisposing factors for CAD. On the other hand there is no strong evidence on the role of genetic factors and the extent by which they could cause this serious disease(Sinorita et al., 2010). Angiotensin converting enzyme (ACE) is an enzyme produced by the pulmonary and renal endothelial cells. This enzyme plays a key role in the production of angiotensin II and in the catabolism of bradykinin, two peptides involved in the modulation of vascular tone and in the proliferation of smooth muscle cells. Angiotensinogen, rennin, ACE, angiotensin-II and angiotensin-II receptors are primary components of rennin-angiotensin system (RAS). This system functions as the major regulator of blood pressure, fluid and electrolyte homeostasis. Disturbances among RAS components plays important role in developing hypertension & other different cardiovascular diseases (Cambien et al., 1992). Genetic variants have been identified in several components of RAS. The reported insertion/deletion polymorphism of the ACE gene has been linked with hypertension (Sayed-Tabatabaei et al., 2006). However studies on its association with other cardiovascular diseases and specially CAD are inconsistent & not well recognized 2014-06-11 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/41513/2/A_STUDY_ON_ANGIO.pdf application/pdf en http://irep.iium.edu.my/41513/3/72_%281%29.pdf Ibrahim, Wisam Nabeel and A.Talib, Norlelawati and Abdullah, Nor Zamzila (2014) A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases. In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014), 11th -13th June 2014, Cultural Activity Center (CAC), Internatioanal Islamic University Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology
spellingShingle	QP Physiology Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases
description	Coronary artery disease (CAD) is a common disease with significantly high morbidity and mortality (Libby et al., 1998). It is also one of the leading causes of death worldwide. In 2012, it was stated that CAD participates in over 30% of Malaysian adult mortality rate (Malaysian death profile, 2013). CAD occurs from complex interactions between variety of environmental and genetic factors. Smoking, alcoholism, and sedentary lifestyle are believed to be the commonest environmental predisposing factors for CAD. On the other hand there is no strong evidence on the role of genetic factors and the extent by which they could cause this serious disease(Sinorita et al., 2010). Angiotensin converting enzyme (ACE) is an enzyme produced by the pulmonary and renal endothelial cells. This enzyme plays a key role in the production of angiotensin II and in the catabolism of bradykinin, two peptides involved in the modulation of vascular tone and in the proliferation of smooth muscle cells. Angiotensinogen, rennin, ACE, angiotensin-II and angiotensin-II receptors are primary components of rennin-angiotensin system (RAS). This system functions as the major regulator of blood pressure, fluid and electrolyte homeostasis. Disturbances among RAS components plays important role in developing hypertension & other different cardiovascular diseases (Cambien et al., 1992). Genetic variants have been identified in several components of RAS. The reported insertion/deletion polymorphism of the ACE gene has been linked with hypertension (Sayed-Tabatabaei et al., 2006). However studies on its association with other cardiovascular diseases and specially CAD are inconsistent & not well recognized
format	Conference or Workshop Item
author	Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila
author_facet	Ibrahim, Wisam Nabeel A.Talib, Norlelawati Abdullah, Nor Zamzila
author_sort	Ibrahim, Wisam Nabeel
title	A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases
title_short	A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases
title_full	A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases
title_fullStr	A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases
title_full_unstemmed	A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases
title_sort	study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases
publishDate	2014
url	http://irep.iium.edu.my/41513/ http://irep.iium.edu.my/41513/2/A_STUDY_ON_ANGIO.pdf http://irep.iium.edu.my/41513/3/72_%281%29.pdf
first_indexed	2023-09-18T20:59:26Z
last_indexed	2023-09-18T20:59:26Z
_version_	1777410524088107008

A study on angiotensin converting enzyme gene insertion/ deletion polymorphism in cardiovascular diseases

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