Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine

A series of fluorobenzoylthioreas bearing a- and b- alanine with different position of fluoro atom substitution have been successfully synthesised and characterised using CHNS micro elemental analysis and spectroscopic method including FTIR, UV-Vis and 1H and 13C NMR. Microelemental analysis data o...

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Main Authors:	Mohamed, Nor Azanita, Ngah, Nurziana, Darnis, Deny Susanti
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/41262/ http://irep.iium.edu.my/41262/1/icnp2014.pdf http://irep.iium.edu.my/41262/3/ICNP2014_nurziana.pdf

id	iium-41262
recordtype	eprints
spelling	iium-412622018-06-19T08:33:43Z http://irep.iium.edu.my/41262/ Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti QD Chemistry A series of fluorobenzoylthioreas bearing a- and b- alanine with different position of fluoro atom substitution have been successfully synthesised and characterised using CHNS micro elemental analysis and spectroscopic method including FTIR, UV-Vis and 1H and 13C NMR. Microelemental analysis data of the compounds were in agreement with the calculated values. The FTIR spectra showed the presence of important bands of the compounds and 1H and 13C exhibited expected chemical shift. Antibacterial and anti fungal activities have been evaluated by zone of inhibition, MIC and MBC/MFC studies against B.cereus, S.epidermidis, E. coli, P.aeruginosa, C. Albicans and T. metagrophytes. Most of the compounds showed moderate antibacterial activity against B.cereus and S.epidermidis and moderate to excellent anti fungal activity against T.metagrophytes. The antimicrobial activities of the compounds were related to the different position of fluoro atom substitution and a-and b-alanine presence in the compounds 2014-03-18 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/41262/1/icnp2014.pdf application/pdf en http://irep.iium.edu.my/41262/3/ICNP2014_nurziana.pdf Mohamed, Nor Azanita and Ngah, Nurziana and Darnis, Deny Susanti (2014) Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine. In: International Conference on Natural Products 2014 (ICNP 2014), 18th-19th March 2014, Palm Garden Hotel, IOI Resorts, Putrajaya, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
description	A series of fluorobenzoylthioreas bearing a- and b- alanine with different position of fluoro atom substitution have been successfully synthesised and characterised using CHNS micro elemental analysis and spectroscopic method including FTIR, UV-Vis and 1H and 13C NMR. Microelemental analysis data of the compounds were in agreement with the calculated values. The FTIR spectra showed the presence of important bands of the compounds and 1H and 13C exhibited expected chemical shift. Antibacterial and anti fungal activities have been evaluated by zone of inhibition, MIC and MBC/MFC studies against B.cereus, S.epidermidis, E. coli, P.aeruginosa, C. Albicans and T. metagrophytes. Most of the compounds showed moderate antibacterial activity against B.cereus and S.epidermidis and moderate to excellent anti fungal activity against T.metagrophytes. The antimicrobial activities of the compounds were related to the different position of fluoro atom substitution and a-and b-alanine presence in the compounds
format	Conference or Workshop Item
author	Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti
author_facet	Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti
author_sort	Mohamed, Nor Azanita
title	Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
title_short	Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
title_full	Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
title_fullStr	Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
title_full_unstemmed	Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
title_sort	synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
publishDate	2014
url	http://irep.iium.edu.my/41262/ http://irep.iium.edu.my/41262/1/icnp2014.pdf http://irep.iium.edu.my/41262/3/ICNP2014_nurziana.pdf
first_indexed	2023-09-18T20:59:07Z
last_indexed	2023-09-18T20:59:07Z
_version_	1777410503636680704

Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine

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