Anti-inflammatory activity of kapok (ceiba pentandra) thorns in acute inflammation
This research was conducted to evaluate the anti-inflammatory effect of Kapok (Ceiba pentandra) thorn extract. Standard screening tests were used to detect for the presence of secondary metabolites such as alkaloids, flavonoids, tannins, steroids, saponin and terpenoids. For anti-inflammatory eff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Asian Academic Research Associates
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/41142/ http://irep.iium.edu.my/41142/ http://irep.iium.edu.my/41142/1/kapok_thorn.pdf |
| Summary: | This research was conducted to evaluate the anti-inflammatory effect of Kapok (Ceiba
pentandra) thorn extract. Standard screening tests were used to detect for the presence of
secondary metabolites such as alkaloids, flavonoids, tannins, steroids, saponin and
terpenoids. For anti-inflammatory effect, carrageenan induced rat paw edema model was
used. Paw edema was initially induced on the right hind paw of rats by subplantar injection
of 0.1ml of carrageenan solution. Then, the contralateral paw was injected with 0.1ml normal
saline as control. Later, the extracts at doses 50 mg/kg and 500 mg/kg were injected
intraperitoneally to the respective rats after 1 h post-carrageenan injection. Dexamethasone
5 mg/kg being used as a positive control the negative control received only saline solution.
Paw volume measurements were recorded immediately by phlethysmometer before and at 1 h
interval after the injection of carrageenan for a period of 7 h. The increase in paw volume
was taken as the volume of edema for each rat. Anti-inflammatory activity was reported as
percentage of edema inhibition compared to the control group. Based on the results obtained,
the extracts showed anti-inflammatory activity at doses 50 mg/kg and 500 mg/kg. Higher
reduction of paw volume was shown at the dose of 50 mg/kg compared to other treatments.
In conclusion, the results showed the extract of C. pentandra thorn has anti-inflammatory
property. This finding, therefore, lead to the basis of using the plant for the traditional
treatment. |
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