Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi

Effect of aqueous and alcoholic extracts of the roots of Mirabilis jalapa Linn. Four Oclock plant, onthe spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation ofSetaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract caused theinhibit...

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Main Authors:	Ahmed, Qamar Uddin, N, Parveen, Khan, Nizam U, SM Kashif, R Zaidi, Singal, KC
Format:	Article
Language:	English
Published:	Springer, Springer Korea Limited, Seoul, Korea (Rep.). 2003
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/40989/ http://irep.iium.edu.my/40989/ http://irep.iium.edu.my/40989/1/Antifilarial_potential_of_the_root_extract_of_the_Mirabilis_jalapa_Linn._%28Nyctaginaceae%29_on_cattle_filarial_parasite_Setaria_cervi.pdf

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spelling	iium-409892015-03-10T00:55:38Z http://irep.iium.edu.my/40989/ Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi Ahmed, Qamar Uddin N, Parveen Khan, Nizam U SM Kashif, R Zaidi Singal, KC Q Science (General) Effect of aqueous and alcoholic extracts of the roots of Mirabilis jalapa Linn. Four Oclock plant, onthe spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation ofSetaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract caused theinhibition of spontaneous movements of the whole worm and the n.m. preparation of S. cervi,whereas aqueous extract caused inhibition of spontaneous movements of the n.m. preparation.The initial stimulatory effect was not observed by aqueous and alcoholic extracts on n.m.preparation while effect of alcoholic extract on the whole worm was characterized by an increasein the amplitude of contractions followed by reversible paralysis. The concentrations required toinhibit the movements of the whole worm and n.m. preparation for alcoholic extract of root were270mg/mL and 40 mg/mL, respectively whereas an aqueous extract caused inhibition of n.m.preparation at 30 mg/mL suggesting a cuticular permeability barrier. Alcoholic extract of the rootsof M. jalapa caused concentration related effect on the survival of microfilariae of S. cervi. The LC50and LC90 for alcoholic extract as observed after 6 hrs. were found to be 10 ng/mL and 18 ng/mL.,respectively. Springer, Springer Korea Limited, Seoul, Korea (Rep.). 2003 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40989/1/Antifilarial_potential_of_the_root_extract_of_the_Mirabilis_jalapa_Linn._%28Nyctaginaceae%29_on_cattle_filarial_parasite_Setaria_cervi.pdf Ahmed, Qamar Uddin and N, Parveen and Khan, Nizam U and SM Kashif, R Zaidi and Singal, KC (2003) Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi. Oriental Pharmacy and Experimental Medicine, 3 (4). pp. 180-186. ISSN 1598-2386 http://opem.or.kr/bbs/board.php?bo_table=m02_12&wr_id=6
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Ahmed, Qamar Uddin N, Parveen Khan, Nizam U SM Kashif, R Zaidi Singal, KC Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
description	Effect of aqueous and alcoholic extracts of the roots of Mirabilis jalapa Linn. Four Oclock plant, onthe spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation ofSetaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract caused theinhibition of spontaneous movements of the whole worm and the n.m. preparation of S. cervi,whereas aqueous extract caused inhibition of spontaneous movements of the n.m. preparation.The initial stimulatory effect was not observed by aqueous and alcoholic extracts on n.m.preparation while effect of alcoholic extract on the whole worm was characterized by an increasein the amplitude of contractions followed by reversible paralysis. The concentrations required toinhibit the movements of the whole worm and n.m. preparation for alcoholic extract of root were270mg/mL and 40 mg/mL, respectively whereas an aqueous extract caused inhibition of n.m.preparation at 30 mg/mL suggesting a cuticular permeability barrier. Alcoholic extract of the rootsof M. jalapa caused concentration related effect on the survival of microfilariae of S. cervi. The LC50and LC90 for alcoholic extract as observed after 6 hrs. were found to be 10 ng/mL and 18 ng/mL.,respectively.
format	Article
author	Ahmed, Qamar Uddin N, Parveen Khan, Nizam U SM Kashif, R Zaidi Singal, KC
author_facet	Ahmed, Qamar Uddin N, Parveen Khan, Nizam U SM Kashif, R Zaidi Singal, KC
author_sort	Ahmed, Qamar Uddin
title	Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_short	Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_full	Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_fullStr	Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_full_unstemmed	Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_sort	antifilarial potential of the root extract of the mirabilis jalapa linn. (nyctaginaceae) on cattle filarial parasite setaria cervi
publisher	Springer, Springer Korea Limited, Seoul, Korea (Rep.).
publishDate	2003
url	http://irep.iium.edu.my/40989/ http://irep.iium.edu.my/40989/ http://irep.iium.edu.my/40989/1/Antifilarial_potential_of_the_root_extract_of_the_Mirabilis_jalapa_Linn._%28Nyctaginaceae%29_on_cattle_filarial_parasite_Setaria_cervi.pdf
first_indexed	2023-09-18T20:58:43Z
last_indexed	2023-09-18T20:58:43Z
_version_	1777410478993047552

Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi

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