Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats

Introduction: The aim of the study is to analyse the antioxidant effect of oral administration of aqueous extract of Annona squamosa (A. squamosa) leaf on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, antioxidant enzymes and lipid peroxidation in liver and kidney to streptozo...

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Main Authors:	Kaleem, Mohammed, Asif, Mohd S., Ahmed, Qamar Uddin, Bano, Bilqees
Format:	Article
Language:	English
Published:	Singapore Medical Association 2006
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/40984/ http://irep.iium.edu.my/40984/ http://irep.iium.edu.my/40984/1/Antidiabetic_and_antioxidant_activity_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf

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spelling	iium-409842015-03-09T08:49:11Z http://irep.iium.edu.my/40984/ Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats Kaleem, Mohammed Asif, Mohd S. Ahmed, Qamar Uddin Bano, Bilqees R Medicine (General) Introduction: The aim of the study is to analyse the antioxidant effect of oral administration of aqueous extract of Annona squamosa (A. squamosa) leaf on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, antioxidant enzymes and lipid peroxidation in liver and kidney to streptozotocin (STZ)-induced diabetic rats. Methods: Aqueous extract of A. squamosa on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, serum lipid and the levels of lipid peroxides and antioxidant enzymes, such as catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione, were examined in the liver and kidney tissues of control and experimental groups. Results: Oral administration of A. squamosa aqueous extract to diabetic rats for 30 days significantly reduced the levels of blood glucose, lipids and lipid peroxidation, but increased the activities of plasma insulin and antioxidant enzymes, like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase. Conclusion: The A. squamosa aqueous extract supplementation is useful in controlling the blood glucose level, improves the plasma insulin, lipid metabolism and is beneficial in preventing diabetic complications from lipid peroxidation and antioxidant systems in experimental diabetic rats; therefore, it could be useful for prevention or early treatment of diabetes mellitus. Singapore Medical Association 2006 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40984/1/Antidiabetic_and_antioxidant_activity_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf Kaleem, Mohammed and Asif, Mohd S. and Ahmed, Qamar Uddin and Bano, Bilqees (2006) Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Medical Journal, 47 (8). pp. 670-675. ISSN 0037-5675 http://www.sma.org.sg/smj/4708/4708a2.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Kaleem, Mohammed Asif, Mohd S. Ahmed, Qamar Uddin Bano, Bilqees Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats
description	Introduction: The aim of the study is to analyse the antioxidant effect of oral administration of aqueous extract of Annona squamosa (A. squamosa) leaf on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, antioxidant enzymes and lipid peroxidation in liver and kidney to streptozotocin (STZ)-induced diabetic rats. Methods: Aqueous extract of A. squamosa on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, serum lipid and the levels of lipid peroxides and antioxidant enzymes, such as catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione, were examined in the liver and kidney tissues of control and experimental groups. Results: Oral administration of A. squamosa aqueous extract to diabetic rats for 30 days significantly reduced the levels of blood glucose, lipids and lipid peroxidation, but increased the activities of plasma insulin and antioxidant enzymes, like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase. Conclusion: The A. squamosa aqueous extract supplementation is useful in controlling the blood glucose level, improves the plasma insulin, lipid metabolism and is beneficial in preventing diabetic complications from lipid peroxidation and antioxidant systems in experimental diabetic rats; therefore, it could be useful for prevention or early treatment of diabetes mellitus.
format	Article
author	Kaleem, Mohammed Asif, Mohd S. Ahmed, Qamar Uddin Bano, Bilqees
author_facet	Kaleem, Mohammed Asif, Mohd S. Ahmed, Qamar Uddin Bano, Bilqees
author_sort	Kaleem, Mohammed
title	Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats
title_short	Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats
title_full	Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats
title_fullStr	Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats
title_full_unstemmed	Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats
title_sort	antidiabetic and antioxidant activity of annona squamosa extract in streptozotocin-induced diabetic rats
publisher	Singapore Medical Association
publishDate	2006
url	http://irep.iium.edu.my/40984/ http://irep.iium.edu.my/40984/ http://irep.iium.edu.my/40984/1/Antidiabetic_and_antioxidant_activity_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf
first_indexed	2023-09-18T20:58:42Z
last_indexed	2023-09-18T20:58:42Z
_version_	1777410478423670784

Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats

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