Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit
INTRODUCTION: Cardiovascular diseases (CVDs) continue to be the single leading cause of deaths globally. Most CVD patients are troubled with a condition known as atherosclerosis. Oxidation of low-density lipoprotein (LDL) and chronic inflammation are the two clinical hallmarks of atherosclerosis. No...
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2014
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| Online Access: | http://irep.iium.edu.my/40686/ http://irep.iium.edu.my/40686/ http://irep.iium.edu.my/40686/1/ANTIATHEROSCLEROTIC_EFFECT.pdf |
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iium-406862015-02-10T03:11:27Z http://irep.iium.edu.my/40686/ Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit Mikail, Maryam Abimbola Ahmed, Idris Adewale Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Md Isa, Muhammad Lokman Draman, Samsul RB Pathology INTRODUCTION: Cardiovascular diseases (CVDs) continue to be the single leading cause of deaths globally. Most CVD patients are troubled with a condition known as atherosclerosis. Oxidation of low-density lipoprotein (LDL) and chronic inflammation are the two clinical hallmarks of atherosclerosis. Not only the fruits that are more known to the common man today, promise a good health, but many underutilized fruits are also nutritious and have medicinal properties. Baccaurea angulata (BA), locally known as ‘belimbing dayak’ or ‘belimbing hutan’, as one of the underutilized fruits, is widely distributed in Borneo Island of Malaysia and several other regions of Indonesia. The present study was conducted to investigate the effects of B. angulata whole fruit on lipid peroxidation, antioxidative enzyme activities, inflammatory biomarkers and atherosclerotic plaque formation in rabbits fed high cholesterol diet. MATERIALS AND METHODS: Twenty five male rabbits of New Zealand strain were used and randomly divided into five groups. Group C was fed 1% cholesterol diet; group C1 was fed 1% cholesterol diet + 0.5ml/kg/day BA whole fruit juice; group C2 was fed 1% cholesterol diet + 1ml/kg/day BA whole fruit juice; group C3 was fed 1% cholesterol diet + 1.5ml/kg/day BA whole fruit juice; group N was fed normal pellet. Blood, aortas and livers were collected for analysis after 12 weeks of feeding. RESULTS AND DISCUSSION: B. angulata juice had higher antioxidants and anti-inflammatory activities indicated by the increase in the antioxidant enzymes and decrease in inflammatory biomarkers, respectively. Likewise, B. angulata juice reduced plaque formation in rabbit aortas. CONCLUSION: It can be concluded that B. angulata juice possesses the ability to counterbalance oxidation reaction, boost antioxidant enzymes, inhibit inflammatory biomarkers and reduce atherosclerotic plaque, which in turn could prevent atherosclerosis. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/40686/1/ANTIATHEROSCLEROTIC_EFFECT.pdf Mikail, Maryam Abimbola and Ahmed, Idris Adewale and Ibrahim, Muhammad and Hazali, Norazlanshah and Abdull Rasad, Mohammad Syaiful Baharii and Abdul Ghani, Radiah and Hashim, Ridzwan and Abdul Wahab, Ridhwan and Md Isa, Muhammad Lokman and Draman, Samsul (2014) Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit. In: K.A.H.S. Research Week 2014, 17-21 Nov. 2014, KAHS IIUM, Kuantan, Pahang. http://www.iium.edu.my/kahs/events/kahs-research-week-2014 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RB Pathology |
| spellingShingle |
RB Pathology Mikail, Maryam Abimbola Ahmed, Idris Adewale Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Md Isa, Muhammad Lokman Draman, Samsul Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit |
| description |
INTRODUCTION: Cardiovascular diseases (CVDs) continue to be the single leading cause of deaths globally. Most CVD patients are troubled with a condition known as atherosclerosis. Oxidation of low-density lipoprotein (LDL) and chronic inflammation are the two clinical hallmarks of atherosclerosis. Not only the fruits that are more known to the common man today, promise a good health, but many underutilized fruits are also nutritious and have medicinal properties. Baccaurea angulata (BA), locally known as ‘belimbing dayak’ or ‘belimbing hutan’, as one of the underutilized fruits, is widely distributed in Borneo Island of Malaysia and several other regions of Indonesia. The present study was conducted to investigate the effects of B. angulata whole fruit on lipid peroxidation, antioxidative enzyme activities, inflammatory biomarkers and atherosclerotic plaque formation in rabbits fed high cholesterol diet. MATERIALS AND METHODS: Twenty five male rabbits of New Zealand strain were used and randomly divided into five groups. Group C was fed 1% cholesterol diet; group C1 was fed 1% cholesterol diet + 0.5ml/kg/day BA whole fruit juice; group C2 was fed 1% cholesterol diet + 1ml/kg/day BA whole fruit juice; group C3 was fed 1% cholesterol diet + 1.5ml/kg/day BA whole fruit juice; group N was fed normal pellet. Blood, aortas and livers were collected for analysis after 12 weeks of feeding. RESULTS AND DISCUSSION: B. angulata juice had higher antioxidants and anti-inflammatory activities indicated by the increase in the antioxidant enzymes and decrease in inflammatory biomarkers, respectively. Likewise, B. angulata juice reduced plaque formation in rabbit aortas. CONCLUSION: It can be concluded that B. angulata juice possesses the ability to counterbalance oxidation reaction, boost antioxidant enzymes, inhibit inflammatory biomarkers and reduce atherosclerotic plaque, which in turn could prevent atherosclerosis. |
| format |
Conference or Workshop Item |
| author |
Mikail, Maryam Abimbola Ahmed, Idris Adewale Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Md Isa, Muhammad Lokman Draman, Samsul |
| author_facet |
Mikail, Maryam Abimbola Ahmed, Idris Adewale Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Md Isa, Muhammad Lokman Draman, Samsul |
| author_sort |
Mikail, Maryam Abimbola |
| title |
Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit |
| title_short |
Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit |
| title_full |
Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit |
| title_fullStr |
Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit |
| title_full_unstemmed |
Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit |
| title_sort |
antiatherosclerotic effect of baccaurea angulate: an under-utilized fruit |
| publishDate |
2014 |
| url |
http://irep.iium.edu.my/40686/ http://irep.iium.edu.my/40686/ http://irep.iium.edu.my/40686/1/ANTIATHEROSCLEROTIC_EFFECT.pdf |
| first_indexed |
2023-09-18T20:58:22Z |
| last_indexed |
2023-09-18T20:58:22Z |
| _version_ |
1777410456612241408 |