Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits

INTRODUCTION: The build-up of cholesterol within the lining of the vascular wall alters vascular structure and function thus interfering with endothelial function and leading to plaques, lesions, occlusion, and embolism. Thus, a considerable effort has been made towards evaluating the impact and mec...

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Main Authors:	Ahmed, Idris Adewale, Mikail, Maryam Abimbola, Ibrahim, Muhammad, Hazali, Norazlanshah, Abdull Rasad, Mohammad Syaiful Baharii, Abdul Ghani, Radiah, Hashim, Ridzwan, Abdul Wahab, Ridhwan, Arief Ichwan, Solachuddin Jauhari, Md Isa, Muhammad Lokman, Draman, Samsul, Ishola, Afeez Adekunle
Format:	Conference or Workshop Item
Language:	English
Published:	2014
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/40684/ http://irep.iium.edu.my/40684/ http://irep.iium.edu.my/40684/1/HYPOCHOLESTEROLEMIC_-_Radiah.pdf

id	iium-40684
recordtype	eprints
spelling	iium-406842015-02-10T02:46:33Z http://irep.iium.edu.my/40684/ Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits Ahmed, Idris Adewale Mikail, Maryam Abimbola Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Arief Ichwan, Solachuddin Jauhari Md Isa, Muhammad Lokman Draman, Samsul Ishola, Afeez Adekunle RB Pathology INTRODUCTION: The build-up of cholesterol within the lining of the vascular wall alters vascular structure and function thus interfering with endothelial function and leading to plaques, lesions, occlusion, and embolism. Thus, a considerable effort has been made towards evaluating the impact and mechanisms of cholesterol-lowering therapies and interventions for cardiovascular outcomes. Therefore, this work was aimed at evaluating the potential health benefit of Baccaurea angulata (BA) fruit in reducing total cholesterol (TC) in serum, aorta and liver of hypercholesterolemic rabbits. MATERIALS AND METHODS: Different doses of BA (0, 0.5, 1.0, and 1.5 mL juice/kg rabbits/day) representing negative control (NgC), low, medium and high doses were given to rabbits fed high-cholesterol diet for 90 days. The result was compared with normal control (NC) group fed commercial pellet only. The serum was obtained from the blood taken at the beginning and end of the experimental period. Rabbits’ liver and thoracic aortas were also homogenized and analysed. RESULTS AND DISCUSSION: The administration of low, medium and high doses of BA fruit juice to high-cholesterol fed rabbits resulted in 21.37, 35.54 and 30.21% reduction in serum TC respectively relative to the negative control. The atherogenic rabbits receiving 1.0 and 1.5 mL/kg/day also had a significant dose-dependent reduction (p<0.05) in their aortic and hepatic TC levels. The aortic TC of the medium and high doses groups were 1.17±0.38 and 1.07±0.32 mmol/L respectively, compared to the NgC and 0.5 mL/kg/day groups with 2.37±0.06 and 1.87±0.55 mmol/L aortic TC respectively. CONCLUSION: Though, the mechanism involved in the reduction of TC in the rabbit serum, liver and aorta by the diet supplementation with BA is yet to be clearly understood, the protective and hypocholesterolemic capacity of BA may be attributed to its antioxidant action thereby attenuating the consequent damage to the heart tissue. Therefore, BA fruit possesses hypocholesterolemic and antioxidant properties. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/40684/1/HYPOCHOLESTEROLEMIC_-_Radiah.pdf Ahmed, Idris Adewale and Mikail, Maryam Abimbola and Ibrahim, Muhammad and Hazali, Norazlanshah and Abdull Rasad, Mohammad Syaiful Baharii and Abdul Ghani, Radiah and Hashim, Ridzwan and Abdul Wahab, Ridhwan and Arief Ichwan, Solachuddin Jauhari and Md Isa, Muhammad Lokman and Draman, Samsul and Ishola, Afeez Adekunle (2014) Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits. In: K.A.H.S. Research Week 2014, 17-21 Nov. 2014, KAHS IIUM, Kuantan, Pahang. http://www.iium.edu.my/kahs/events/kahs-research-week-2014
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Ahmed, Idris Adewale Mikail, Maryam Abimbola Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Arief Ichwan, Solachuddin Jauhari Md Isa, Muhammad Lokman Draman, Samsul Ishola, Afeez Adekunle Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits
description	INTRODUCTION: The build-up of cholesterol within the lining of the vascular wall alters vascular structure and function thus interfering with endothelial function and leading to plaques, lesions, occlusion, and embolism. Thus, a considerable effort has been made towards evaluating the impact and mechanisms of cholesterol-lowering therapies and interventions for cardiovascular outcomes. Therefore, this work was aimed at evaluating the potential health benefit of Baccaurea angulata (BA) fruit in reducing total cholesterol (TC) in serum, aorta and liver of hypercholesterolemic rabbits. MATERIALS AND METHODS: Different doses of BA (0, 0.5, 1.0, and 1.5 mL juice/kg rabbits/day) representing negative control (NgC), low, medium and high doses were given to rabbits fed high-cholesterol diet for 90 days. The result was compared with normal control (NC) group fed commercial pellet only. The serum was obtained from the blood taken at the beginning and end of the experimental period. Rabbits’ liver and thoracic aortas were also homogenized and analysed. RESULTS AND DISCUSSION: The administration of low, medium and high doses of BA fruit juice to high-cholesterol fed rabbits resulted in 21.37, 35.54 and 30.21% reduction in serum TC respectively relative to the negative control. The atherogenic rabbits receiving 1.0 and 1.5 mL/kg/day also had a significant dose-dependent reduction (p<0.05) in their aortic and hepatic TC levels. The aortic TC of the medium and high doses groups were 1.17±0.38 and 1.07±0.32 mmol/L respectively, compared to the NgC and 0.5 mL/kg/day groups with 2.37±0.06 and 1.87±0.55 mmol/L aortic TC respectively. CONCLUSION: Though, the mechanism involved in the reduction of TC in the rabbit serum, liver and aorta by the diet supplementation with BA is yet to be clearly understood, the protective and hypocholesterolemic capacity of BA may be attributed to its antioxidant action thereby attenuating the consequent damage to the heart tissue. Therefore, BA fruit possesses hypocholesterolemic and antioxidant properties.
format	Conference or Workshop Item
author	Ahmed, Idris Adewale Mikail, Maryam Abimbola Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Arief Ichwan, Solachuddin Jauhari Md Isa, Muhammad Lokman Draman, Samsul Ishola, Afeez Adekunle
author_facet	Ahmed, Idris Adewale Mikail, Maryam Abimbola Ibrahim, Muhammad Hazali, Norazlanshah Abdull Rasad, Mohammad Syaiful Baharii Abdul Ghani, Radiah Hashim, Ridzwan Abdul Wahab, Ridhwan Arief Ichwan, Solachuddin Jauhari Md Isa, Muhammad Lokman Draman, Samsul Ishola, Afeez Adekunle
author_sort	Ahmed, Idris Adewale
title	Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits
title_short	Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits
title_full	Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits
title_fullStr	Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits
title_full_unstemmed	Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits
title_sort	potential hypocholesterolemic and health benefitsof baccaurea angulata fruit in hypercholesterolemic rabbits
publishDate	2014
url	http://irep.iium.edu.my/40684/ http://irep.iium.edu.my/40684/ http://irep.iium.edu.my/40684/1/HYPOCHOLESTEROLEMIC_-_Radiah.pdf
first_indexed	2023-09-18T20:58:22Z
last_indexed	2023-09-18T20:58:22Z
_version_	1777410456453906432

Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits

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