The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis

Purpose: The aim of this study is to evaluate the effectiveness of tobramycin pellet (OSTEOSET ® T) in eradicating osteomyelitis of long bone. Design: Retrospective case series Setting: Advance trauma and Limb reconstruction Unit, Dept of Orthopaedic, HTAA Patients/ participants: Patient trea...

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Main Author:	Mohd Yusof, Nazri
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/40567/ http://irep.iium.edu.my/40567/1/The_efficiacy_of_the_Tobramycin.pdf

id	iium-40567
recordtype	eprints
spelling	iium-405672015-02-09T08:16:40Z http://irep.iium.edu.my/40567/ The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis Mohd Yusof, Nazri RD701 Orthopedics Purpose: The aim of this study is to evaluate the effectiveness of tobramycin pellet (OSTEOSET ® T) in eradicating osteomyelitis of long bone. Design: Retrospective case series Setting: Advance trauma and Limb reconstruction Unit, Dept of Orthopaedic, HTAA Patients/ participants: Patient treated for osteomyelitis of long bone in Advance trauma and Limb reconstruction Unit Intervention: Debridement of infected soft tissue and bone, insertion of calcium sulphate pellet, direct wound closure or with local flaps, external fixation followed by bone grafting or bone transport. Main outcome measures: The primary outcome is eradication of infection. Secondary outcomes include fracture union, Enneking functional score and Lower Extremity Functional Scale. Results: Twelve patients (80%) achieved control of infection. Three patients’ undergone repeated debridement because of persistent serous discharge. In one patient the infection was due to retained implant and repeated culture grew MRSA. Two patients had inadequate resection and repeated culture also grew MRSA in one of them and the other did not grow any organism. Conclusion: Tobramycin pellet is effective adjuvant therapy for osteomyelitis. However, aggressive debridement is still mandatory to achieve control of infection. Significance: Removal of foreign body and adequate debridement are necessary to control osteomyelitis. Tobramycin pellet is useful as adjuvant treatment for osteomyelitis. Local antibiotic delivery was developed to achieve high local concentration of antibiotic while maintaining low level systemic antibiotic levels. It also obliterates dead space that left following resection of osteomyelitic bone 2013-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/40567/1/The_efficiacy_of_the_Tobramycin.pdf Mohd Yusof, Nazri (2013) The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis. In: 5th APOA Infection Section Scientific Meeting, 29-31 August 2013, Pullman Kuching, Sarawak. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Mohd Yusof, Nazri The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis
description	Purpose: The aim of this study is to evaluate the effectiveness of tobramycin pellet (OSTEOSET ® T) in eradicating osteomyelitis of long bone. Design: Retrospective case series Setting: Advance trauma and Limb reconstruction Unit, Dept of Orthopaedic, HTAA Patients/ participants: Patient treated for osteomyelitis of long bone in Advance trauma and Limb reconstruction Unit Intervention: Debridement of infected soft tissue and bone, insertion of calcium sulphate pellet, direct wound closure or with local flaps, external fixation followed by bone grafting or bone transport. Main outcome measures: The primary outcome is eradication of infection. Secondary outcomes include fracture union, Enneking functional score and Lower Extremity Functional Scale. Results: Twelve patients (80%) achieved control of infection. Three patients’ undergone repeated debridement because of persistent serous discharge. In one patient the infection was due to retained implant and repeated culture grew MRSA. Two patients had inadequate resection and repeated culture also grew MRSA in one of them and the other did not grow any organism. Conclusion: Tobramycin pellet is effective adjuvant therapy for osteomyelitis. However, aggressive debridement is still mandatory to achieve control of infection. Significance: Removal of foreign body and adequate debridement are necessary to control osteomyelitis. Tobramycin pellet is useful as adjuvant treatment for osteomyelitis. Local antibiotic delivery was developed to achieve high local concentration of antibiotic while maintaining low level systemic antibiotic levels. It also obliterates dead space that left following resection of osteomyelitic bone
format	Conference or Workshop Item
author	Mohd Yusof, Nazri
author_facet	Mohd Yusof, Nazri
author_sort	Mohd Yusof, Nazri
title	The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis
title_short	The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis
title_full	The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis
title_fullStr	The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis
title_full_unstemmed	The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis
title_sort	efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis
publishDate	2013
url	http://irep.iium.edu.my/40567/ http://irep.iium.edu.my/40567/1/The_efficiacy_of_the_Tobramycin.pdf
first_indexed	2023-09-18T20:58:14Z
last_indexed	2023-09-18T20:58:14Z
_version_	1777410448077881344

The efficacy of tobramycin pellet as a local drug delivery in the treatment of osteomyelitis

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