Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria

It is important to find new ways that are effective for the treatment of infectious diseases caused by drug-resistant bacteria such as the usage of plant extracts such as prophetic medicine which have the antibacterial activity together with antibiotics which do provide synergistic effect. The objec...

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Main Authors:	Mohamed Ali, Insathe, Darnis, Deny Susanti
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/40513/ http://irep.iium.edu.my/40513/2/poster_sympo_4.pdf http://irep.iium.edu.my/40513/6/synergism.pdf

id	iium-40513
recordtype	eprints
spelling	iium-405132015-01-06T07:07:55Z http://irep.iium.edu.my/40513/ Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria Mohamed Ali, Insathe Darnis, Deny Susanti Q Science (General) It is important to find new ways that are effective for the treatment of infectious diseases caused by drug-resistant bacteria such as the usage of plant extracts such as prophetic medicine which have the antibacterial activity together with antibiotics which do provide synergistic effect. The objectives of this study are to evaluate synergism between different types of prophetic medicine and antibiotics towards different bacterial strains and to increase the susceptibility of antibiotic resistant bacteria towards different types of antibiotics with the usage of Prophetic medicine. Three samples of Prophetic medicine had been used such as Allium Cepa (Onion), Aloe Vera (Aloe) and Ocimum basilicum (Basil) was prepared by the method freeze drying. Those samples are combined with several types of antibiotics like ampicillin, erythromycin, penicillin, streptomycin and tetracycline and were tested against different types of bacteria which are S.aureus, B.cereus, E.coli and P.aeruginosa by using broth microdilution method in order to determine the minimum inhibitory concentration (MIC). Fractional inhibitory concentration (FIC) was determined in order to know the synergy interaction between the prophetic medicine and antibiotics. The antibiotic penicillin produces synergistic effect when being combined with onion in order to combat the bacteria S.aureus, B.cereus and E.coli. The combination between onion and both ampicillin and erythromycin also have synergism toward overcoming the bacteria E.coli. Other than that combination of basil with both ampicillin and penicillin also produces synergistic effect upon combating B.cereus while, for aloe it produces synergism when being combined with tetracycline and penicillin in order to combat the bacteria S.aureus and E.coli respectively. Most of the effect of synergism observed when prophetic medicine was given with the antibiotic penicillin. Hence it can be concluded that only certain Prophetic Medicine can provide synergistic effect with certain types of antibiotic in order to combat a particular bacteria due to their different ways of combating the bacteria and only antibacterial activity of both at the same place will have synergistic effect. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/40513/2/poster_sympo_4.pdf application/pdf en http://irep.iium.edu.my/40513/6/synergism.pdf Mohamed Ali, Insathe and Darnis, Deny Susanti (2014) Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria. In: 5th Malaysian Symposium of Biomedical Science, 10th-11th May 2014, UKM Kuala Lumpur Campus, Kuala Lumpur.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Mohamed Ali, Insathe Darnis, Deny Susanti Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria
description	It is important to find new ways that are effective for the treatment of infectious diseases caused by drug-resistant bacteria such as the usage of plant extracts such as prophetic medicine which have the antibacterial activity together with antibiotics which do provide synergistic effect. The objectives of this study are to evaluate synergism between different types of prophetic medicine and antibiotics towards different bacterial strains and to increase the susceptibility of antibiotic resistant bacteria towards different types of antibiotics with the usage of Prophetic medicine. Three samples of Prophetic medicine had been used such as Allium Cepa (Onion), Aloe Vera (Aloe) and Ocimum basilicum (Basil) was prepared by the method freeze drying. Those samples are combined with several types of antibiotics like ampicillin, erythromycin, penicillin, streptomycin and tetracycline and were tested against different types of bacteria which are S.aureus, B.cereus, E.coli and P.aeruginosa by using broth microdilution method in order to determine the minimum inhibitory concentration (MIC). Fractional inhibitory concentration (FIC) was determined in order to know the synergy interaction between the prophetic medicine and antibiotics. The antibiotic penicillin produces synergistic effect when being combined with onion in order to combat the bacteria S.aureus, B.cereus and E.coli. The combination between onion and both ampicillin and erythromycin also have synergism toward overcoming the bacteria E.coli. Other than that combination of basil with both ampicillin and penicillin also produces synergistic effect upon combating B.cereus while, for aloe it produces synergism when being combined with tetracycline and penicillin in order to combat the bacteria S.aureus and E.coli respectively. Most of the effect of synergism observed when prophetic medicine was given with the antibiotic penicillin. Hence it can be concluded that only certain Prophetic Medicine can provide synergistic effect with certain types of antibiotic in order to combat a particular bacteria due to their different ways of combating the bacteria and only antibacterial activity of both at the same place will have synergistic effect.
format	Conference or Workshop Item
author	Mohamed Ali, Insathe Darnis, Deny Susanti
author_facet	Mohamed Ali, Insathe Darnis, Deny Susanti
author_sort	Mohamed Ali, Insathe
title	Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria
title_short	Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria
title_full	Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria
title_fullStr	Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria
title_full_unstemmed	Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria
title_sort	synergism between antibiotics and the extract of selected prophet medicine toward different types of bacteria
publishDate	2014
url	http://irep.iium.edu.my/40513/ http://irep.iium.edu.my/40513/2/poster_sympo_4.pdf http://irep.iium.edu.my/40513/6/synergism.pdf
first_indexed	2023-09-18T20:58:09Z
last_indexed	2023-09-18T20:58:09Z
_version_	1777410443665473536

Synergism between antibiotics and the extract of selected Prophet medicine toward different types of bacteria

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