Isolation and anti-proliferative activity of natural products from green seaweed

Seaweeds are marine organism that is chemically rich in source of different bioactive compounds of secondary metabolites. Selected green seaweed has been commonly consumed as human food due to their nutrient content. However, huge numbers of bioactive metabolites from green seaweed has been unexplor...

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Main Authors:	Zulhedi Ilyas, Fitriyanti, Darnis, Deny Susanti, Mohammad Noor, Normawaty, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/40506/ http://irep.iium.edu.my/40506/1/ICSTIE2014.pdf http://irep.iium.edu.my/40506/6/Green_Seaweed_.pdf

id	iium-40506
recordtype	eprints
spelling	iium-405062015-01-26T02:48:43Z http://irep.iium.edu.my/40506/ Isolation and anti-proliferative activity of natural products from green seaweed Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher QD Chemistry Seaweeds are marine organism that is chemically rich in source of different bioactive compounds of secondary metabolites. Selected green seaweed has been commonly consumed as human food due to their nutrient content. However, huge numbers of bioactive metabolites from green seaweed has been unexplored yet. The aims of this study are to isolate phytochemical from selected Malaysian seaweed and to investigate the antiproliferative activity of isolated compounds. Seaweed is extracted by soxhlet extractor with using organic solvents for 24 hours, and then the crude seaweed is fractionated by vacuum liquid chromatography and column chromatography. The isolated compounds of seaweed are characterized by HRMS, FTIR spectroscopy, 1D and 2D NMR spectroscopy. They also are studied for their ability to inhibit cell proliferation of breast cancer cell MCF-7 using MTT assay. Two isolated compounds that were identified as Coumarin derivative showed activity against MCF-7. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/40506/1/ICSTIE2014.pdf application/pdf en http://irep.iium.edu.my/40506/6/Green_Seaweed_.pdf Zulhedi Ilyas, Fitriyanti and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2014) Isolation and anti-proliferative activity of natural products from green seaweed. In: 5th International Conference on Science & Technology: Applications in Industry & Education (ICSTIE 2014), 17-18 September 2014, Parkroyal Resort, Penang.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher Isolation and anti-proliferative activity of natural products from green seaweed
description	Seaweeds are marine organism that is chemically rich in source of different bioactive compounds of secondary metabolites. Selected green seaweed has been commonly consumed as human food due to their nutrient content. However, huge numbers of bioactive metabolites from green seaweed has been unexplored yet. The aims of this study are to isolate phytochemical from selected Malaysian seaweed and to investigate the antiproliferative activity of isolated compounds. Seaweed is extracted by soxhlet extractor with using organic solvents for 24 hours, and then the crude seaweed is fractionated by vacuum liquid chromatography and column chromatography. The isolated compounds of seaweed are characterized by HRMS, FTIR spectroscopy, 1D and 2D NMR spectroscopy. They also are studied for their ability to inhibit cell proliferation of breast cancer cell MCF-7 using MTT assay. Two isolated compounds that were identified as Coumarin derivative showed activity against MCF-7.
format	Conference or Workshop Item
author	Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher
author_facet	Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher
author_sort	Zulhedi Ilyas, Fitriyanti
title	Isolation and anti-proliferative activity of natural products from green seaweed
title_short	Isolation and anti-proliferative activity of natural products from green seaweed
title_full	Isolation and anti-proliferative activity of natural products from green seaweed
title_fullStr	Isolation and anti-proliferative activity of natural products from green seaweed
title_full_unstemmed	Isolation and anti-proliferative activity of natural products from green seaweed
title_sort	isolation and anti-proliferative activity of natural products from green seaweed
publishDate	2014
url	http://irep.iium.edu.my/40506/ http://irep.iium.edu.my/40506/1/ICSTIE2014.pdf http://irep.iium.edu.my/40506/6/Green_Seaweed_.pdf
first_indexed	2023-09-18T20:58:08Z
last_indexed	2023-09-18T20:58:08Z
_version_	1777410442626334720

Isolation and anti-proliferative activity of natural products from green seaweed

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