Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects

Purpose: The purpose was to determine the within-session variability and between-session repeatability of SD-OCT Doppler measurement of retinal blood flow in young and elderly healthy subjects. Methods: SD-OCT Doppler blood flow was non-invasively measured using the RTVue system (Optovue Inc., USA)...

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Main Authors:	Tayyari, Faryan, Yusof @ Alias, Firdaus, Vymyslicky, Michal, Flanagan, John G, Hudson, Christopher
Format:	Article
Language:	English
Published:	The Association for Research in Vision and Ophthalmology, Inc. 2014
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/40375/ http://irep.iium.edu.my/40375/ http://irep.iium.edu.my/40375/ http://irep.iium.edu.my/40375/1/40375.pdf

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spelling	iium-403752018-05-24T04:50:30Z http://irep.iium.edu.my/40375/ Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects Tayyari, Faryan Yusof @ Alias, Firdaus Vymyslicky, Michal Flanagan, John G Hudson, Christopher RE Ophthalmology Purpose: The purpose was to determine the within-session variability and between-session repeatability of SD-OCT Doppler measurement of retinal blood flow in young and elderly healthy subjects. Methods: SD-OCT Doppler blood flow was non-invasively measured using the RTVue system (Optovue Inc., USA). One eye of each of 6 healthy young (mean age 25.7; SD 3.5 years) and 6 healthy elderly (mean age 63.1; SD 1.8 years) subjects was randomly selected for the study and the pupil was dilated using Mydriacyl 1%. A double circular scanning pattern was employed. A minimum of six separate SD-OCT Doppler measurements (i.e. each separate measurement comprising an upper nasal pupil scan and a lower nasal pupil scan) were acquired at each session. Measurements were repeated on a second day. Retinal blood flow was calculated, using data from valid scans only, by summing flow from all detectable venules. The coefficient of variation and the coefficient of repeatability were calculated for each individual. Results: The individual COVs for retinal blood flow for young subjects ranged from 2 to 51.9% (median 28.8%) and for the elderly subjects ranged from 0.6 to 81.2% (median 9.9%). The group mean CORs for retinal blood flow for young subjects were 30.5 μl/min (median 29.5 μl/min, relative to a mean effect 39.8 μl/min) and for elderly subjects were 16.9 μl/min (median 7.2 μl/min, relative to a mean effect 34.7 μl/min). Conclusions: The Doppler SD-OCT in general gave consistent measurements of retinal blood flow in normal subjects, while the data was far more repeatable for the elderly group. The relatively small sample size needs to be considered when interpreting these results. The Association for Research in Vision and Ophthalmology, Inc. 2014-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40375/1/40375.pdf Tayyari, Faryan and Yusof @ Alias, Firdaus and Vymyslicky, Michal and Flanagan, John G and Hudson, Christopher (2014) Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects. Investigative Ophthalmology & Visual Science, 55 (12). pp. 7716-7725. ISSN 0146-0404 http://iovs.arvojournals.org/article.aspx?articleid=2212627 10.1167/iovs.14-14430
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Tayyari, Faryan Yusof @ Alias, Firdaus Vymyslicky, Michal Flanagan, John G Hudson, Christopher Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects
description	Purpose: The purpose was to determine the within-session variability and between-session repeatability of SD-OCT Doppler measurement of retinal blood flow in young and elderly healthy subjects. Methods: SD-OCT Doppler blood flow was non-invasively measured using the RTVue system (Optovue Inc., USA). One eye of each of 6 healthy young (mean age 25.7; SD 3.5 years) and 6 healthy elderly (mean age 63.1; SD 1.8 years) subjects was randomly selected for the study and the pupil was dilated using Mydriacyl 1%. A double circular scanning pattern was employed. A minimum of six separate SD-OCT Doppler measurements (i.e. each separate measurement comprising an upper nasal pupil scan and a lower nasal pupil scan) were acquired at each session. Measurements were repeated on a second day. Retinal blood flow was calculated, using data from valid scans only, by summing flow from all detectable venules. The coefficient of variation and the coefficient of repeatability were calculated for each individual. Results: The individual COVs for retinal blood flow for young subjects ranged from 2 to 51.9% (median 28.8%) and for the elderly subjects ranged from 0.6 to 81.2% (median 9.9%). The group mean CORs for retinal blood flow for young subjects were 30.5 μl/min (median 29.5 μl/min, relative to a mean effect 39.8 μl/min) and for elderly subjects were 16.9 μl/min (median 7.2 μl/min, relative to a mean effect 34.7 μl/min). Conclusions: The Doppler SD-OCT in general gave consistent measurements of retinal blood flow in normal subjects, while the data was far more repeatable for the elderly group. The relatively small sample size needs to be considered when interpreting these results.
format	Article
author	Tayyari, Faryan Yusof @ Alias, Firdaus Vymyslicky, Michal Flanagan, John G Hudson, Christopher
author_facet	Tayyari, Faryan Yusof @ Alias, Firdaus Vymyslicky, Michal Flanagan, John G Hudson, Christopher
author_sort	Tayyari, Faryan
title	Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects
title_short	Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects
title_full	Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects
title_fullStr	Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects
title_full_unstemmed	Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects
title_sort	variability and repeatability of quantitative, sd-oct doppler blood flow in young and elderly healthy subjects
publisher	The Association for Research in Vision and Ophthalmology, Inc.
publishDate	2014
url	http://irep.iium.edu.my/40375/ http://irep.iium.edu.my/40375/ http://irep.iium.edu.my/40375/ http://irep.iium.edu.my/40375/1/40375.pdf
first_indexed	2023-09-18T20:57:55Z
last_indexed	2023-09-18T20:57:55Z
_version_	1777410428485238784

Variability and repeatability of quantitative, SD-OCT doppler blood flow in young and elderly healthy subjects

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