Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects

Purpose. The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young and elderly subjects. Methods. Doppler FD-OCT blood flow w...

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Main Authors:	Tayyari, Faryan Tayyari, Yusof, Firdaus, Vymyslicky, Michal, Tan, Ou, Huang, David, Flanagan, John G. Flanagan, Hudson, Christopher
Format:	Article
Language:	English English
Published:	The Association for Research in Vision and Ophthalmology, Inc. 2014
Subjects:	QC Physics RE Ophthalmology
Online Access:	http://irep.iium.edu.my/40327/ http://irep.iium.edu.my/40327/ http://irep.iium.edu.my/40327/ http://irep.iium.edu.my/40327/1/FYA_variability_IOVS_paper.pdf http://irep.iium.edu.my/40327/4/40327_Variability%20and%20repeatability%20of%20quantitative_scopus.pdf

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spelling	iium-403272017-09-19T02:57:15Z http://irep.iium.edu.my/40327/ Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects Tayyari, Faryan Tayyari Yusof, Firdaus Vymyslicky, Michal Tan, Ou Huang, David Flanagan, John G. Flanagan Hudson, Christopher QC Physics RE Ophthalmology Purpose. The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young and elderly subjects. Methods. Doppler FD-OCT blood flow was measured using the RTVue system. One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ±5.1 years) subjects was randomly selected, and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e., each separate measurement comprising an upper and a lower nasal pupil scan) were acquired at each session. Measurements were repeated approximately 2 weeks later. Total retinal blood flow was calculated by summing flow from all detectable venules surrounding the optic nerve head. The coefficient of variation (COV) and coefficient of repeatability (COR) were calculated for each individual. Results. The individual COVs for retinal blood flow for young subjects ranged from 0.4% to 20.4% (median 7.5%) and for the elderly subjects ranged from 0.6% to 34.6% (median 9.2%). The group mean CORs for retinal blood flow for young participants were 6.4 μL/min (median 5.91 μL/min, relative to a mean effect 39.8 μL/min) and for elderly subjects were 10.5 μL/min (median 9.2 μL/min, relative to a mean effect 46.4 μL/min). Conclusions. Doppler FD-OCT gave consistent and repeatable blood flow measurements within retinal venules in normal subjects. Considering the individual variation in blood flow measurements, confidence limits for retinal hemodynamics need to be determined on an individual basis. The Association for Research in Vision and Ophthalmology, Inc. 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40327/1/FYA_variability_IOVS_paper.pdf application/pdf en http://irep.iium.edu.my/40327/4/40327_Variability%20and%20repeatability%20of%20quantitative_scopus.pdf Tayyari, Faryan Tayyari and Yusof, Firdaus and Vymyslicky, Michal and Tan, Ou and Huang, David and Flanagan, John G. Flanagan and Hudson, Christopher (2014) Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects. Investigative Ophthalmology & Visual Science, 55 (12). pp. 7716-7725. ISSN 0146-0404 http://www.iovs.org/content/current 10.1167/iovs.14-14430
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QC Physics RE Ophthalmology
spellingShingle	QC Physics RE Ophthalmology Tayyari, Faryan Tayyari Yusof, Firdaus Vymyslicky, Michal Tan, Ou Huang, David Flanagan, John G. Flanagan Hudson, Christopher Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
description	Purpose. The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young and elderly subjects. Methods. Doppler FD-OCT blood flow was measured using the RTVue system. One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ±5.1 years) subjects was randomly selected, and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e., each separate measurement comprising an upper and a lower nasal pupil scan) were acquired at each session. Measurements were repeated approximately 2 weeks later. Total retinal blood flow was calculated by summing flow from all detectable venules surrounding the optic nerve head. The coefficient of variation (COV) and coefficient of repeatability (COR) were calculated for each individual. Results. The individual COVs for retinal blood flow for young subjects ranged from 0.4% to 20.4% (median 7.5%) and for the elderly subjects ranged from 0.6% to 34.6% (median 9.2%). The group mean CORs for retinal blood flow for young participants were 6.4 μL/min (median 5.91 μL/min, relative to a mean effect 39.8 μL/min) and for elderly subjects were 10.5 μL/min (median 9.2 μL/min, relative to a mean effect 46.4 μL/min). Conclusions. Doppler FD-OCT gave consistent and repeatable blood flow measurements within retinal venules in normal subjects. Considering the individual variation in blood flow measurements, confidence limits for retinal hemodynamics need to be determined on an individual basis.
format	Article
author	Tayyari, Faryan Tayyari Yusof, Firdaus Vymyslicky, Michal Tan, Ou Huang, David Flanagan, John G. Flanagan Hudson, Christopher
author_facet	Tayyari, Faryan Tayyari Yusof, Firdaus Vymyslicky, Michal Tan, Ou Huang, David Flanagan, John G. Flanagan Hudson, Christopher
author_sort	Tayyari, Faryan Tayyari
title	Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_short	Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_full	Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_fullStr	Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_full_unstemmed	Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_sort	variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
publisher	The Association for Research in Vision and Ophthalmology, Inc.
publishDate	2014
url	http://irep.iium.edu.my/40327/ http://irep.iium.edu.my/40327/ http://irep.iium.edu.my/40327/ http://irep.iium.edu.my/40327/1/FYA_variability_IOVS_paper.pdf http://irep.iium.edu.my/40327/4/40327_Variability%20and%20repeatability%20of%20quantitative_scopus.pdf
first_indexed	2023-09-18T20:57:50Z
last_indexed	2023-09-18T20:57:50Z
_version_	1777410423680663552

Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects

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