Cytotoxic tirucallane triterpenes from the stem of luvunga scandens

Two tirucallane triterpenes, namely flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures...

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Main Authors:	Al Zikri, Putri Nurhidayah, Bakhtiar, M. Taher, Darnis, Deny Susanti, Rezali, Mohd Fazlin, Read, Roger W, Sohrab, Md. Hossain, Hasan, Choudhury Mahmood, Ahmad, Farediah
Format:	Article
Language:	English English
Published:	Sociedade Brasileira de Farmacognosia 2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/40039/ http://irep.iium.edu.my/40039/ http://irep.iium.edu.my/40039/1/Putri_et_al_2014.pdf http://irep.iium.edu.my/40039/4/40039_Cytotoxic%20tirucallane%20triterpenes_SCOPUS.pdf

id	iium-40039
recordtype	eprints
spelling	iium-400392017-09-19T07:17:47Z http://irep.iium.edu.my/40039/ Cytotoxic tirucallane triterpenes from the stem of luvunga scandens Al Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah RS Pharmacy and materia medica Two tirucallane triterpenes, namely flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures were constructed by high resolution mass and 2D NMR spectroscopic data. The cytotoxic potential of the two pure compounds 1 and 2 were determined by MTT assay against human breast adenocarcinoma cell line (MCF-7). Compounds 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 μM, respec- tively. This result suggested their potential activity as antitumor agents. Sociedade Brasileira de Farmacognosia 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40039/1/Putri_et_al_2014.pdf application/pdf en http://irep.iium.edu.my/40039/4/40039_Cytotoxic%20tirucallane%20triterpenes_SCOPUS.pdf Al Zikri, Putri Nurhidayah and Bakhtiar, M. Taher and Darnis, Deny Susanti and Rezali, Mohd Fazlin and Read, Roger W and Sohrab, Md. Hossain and Hasan, Choudhury Mahmood and Ahmad, Farediah (2014) Cytotoxic tirucallane triterpenes from the stem of luvunga scandens. Brazilian Journal of Pharmacognosy, 24 (5). pp. 561-564. ISSN 0102-695X http://www.journals.elsevier.com/revista-brasileira-de-farmacognosia
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Al Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah Cytotoxic tirucallane triterpenes from the stem of luvunga scandens
description	Two tirucallane triterpenes, namely flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures were constructed by high resolution mass and 2D NMR spectroscopic data. The cytotoxic potential of the two pure compounds 1 and 2 were determined by MTT assay against human breast adenocarcinoma cell line (MCF-7). Compounds 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 μM, respec- tively. This result suggested their potential activity as antitumor agents.
format	Article
author	Al Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah
author_facet	Al Zikri, Putri Nurhidayah Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Read, Roger W Sohrab, Md. Hossain Hasan, Choudhury Mahmood Ahmad, Farediah
author_sort	Al Zikri, Putri Nurhidayah
title	Cytotoxic tirucallane triterpenes from the stem of luvunga scandens
title_short	Cytotoxic tirucallane triterpenes from the stem of luvunga scandens
title_full	Cytotoxic tirucallane triterpenes from the stem of luvunga scandens
title_fullStr	Cytotoxic tirucallane triterpenes from the stem of luvunga scandens
title_full_unstemmed	Cytotoxic tirucallane triterpenes from the stem of luvunga scandens
title_sort	cytotoxic tirucallane triterpenes from the stem of luvunga scandens
publisher	Sociedade Brasileira de Farmacognosia
publishDate	2014
url	http://irep.iium.edu.my/40039/ http://irep.iium.edu.my/40039/ http://irep.iium.edu.my/40039/1/Putri_et_al_2014.pdf http://irep.iium.edu.my/40039/4/40039_Cytotoxic%20tirucallane%20triterpenes_SCOPUS.pdf
first_indexed	2023-09-18T20:57:28Z
last_indexed	2023-09-18T20:57:28Z
_version_	1777410400722092032

Cytotoxic tirucallane triterpenes from the stem of luvunga scandens

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