Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan
Infective endocarditis (IE) remains a life threatening infection that is virtually always fatal if untreated. Despite advances in early diagnosis and treatment, several studies have reported an increase in the incidence of IE with notable changes in the nature of underlying cardiac disease. Degene...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Databases of Indian Medical Journals
2006
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/39596/ http://irep.iium.edu.my/39596/ http://irep.iium.edu.my/39596/1/%28IE%292006.pdf |
| Summary: | Infective endocarditis (IE) remains a life threatening infection that is virtually always fatal if untreated.
Despite advances in early diagnosis and treatment, several studies have reported an increase in the incidence
of IE with notable changes in the nature of underlying cardiac disease. Degenerative, prosthetic, iatrogenic
valvular disease and IE among intravenous drug users (IVDU) are now reported more frequently than rheumatic
heart disease. The objective of this study was to determine the frequency of IE, its predisposing factors,
microbiological status, and outcome at a state hospital in eastern Malaysia. Sixty seven inpatients diagnosed as
IE or suspected IE from June 2000 till July 2002 were identified from hospital records out of which 45 cases that
fulfilled the Duke criteria for diagnosis were included in the present study. The patients’ predisposing factors,
clinical findings, complications, results of investigations and data on clinical outcome were extracted. There
were 44 male and 1 female cases with a mean age of 31.9 years, of which 86.7% were IVDUs. Fifteen of our
patients were HIV positive, all of whom were IVDU. There was no statistically .significant difference in
bacteriology and echocardiography findings among HIV-positive and HIV-negative patients. Among IVDU,
Staphylococcus aureus was the most common organism (61.5%) followed by streptococci (17.9%). Among
non-IVDU, streptococci were isolated in 66.6 % cases, and Staphylococcus aureus in 1 case (16.6%). All cases
were treated medically and median follow up was 6 months. A successful outcome was seen in 91% of patients.
Conclusion: Intravenous drug use is the commonest predisposing factor for IE among our patients. |
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