Antimicrobial study of the leaves extracts of atocarpus lanceifolius

Infectious diseases constitute an arising number of annual deaths recorded worldwide. The world is currently experiencing challenges of increased resistance development against available antimicrobial drugs. Therefore, the search for new antimicrobial drug is urgently needed to reduce the burden of...

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Main Authors:	Mohamed Safri, Fatim Nasuha, Bakhtiar, M. Taher, Darnis, Deny Susanti
Format:	Conference or Workshop Item
Language:	English English English
Published:	2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/39552/ http://irep.iium.edu.my/39552/ http://irep.iium.edu.my/39552/2/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39552/3/IHCI_2014_Programme_Book.pdf http://irep.iium.edu.my/39552/8/poster_ihci_fatim-2.pdf

id	iium-39552
recordtype	eprints
spelling	iium-395522015-01-06T07:03:47Z http://irep.iium.edu.my/39552/ Antimicrobial study of the leaves extracts of atocarpus lanceifolius Mohamed Safri, Fatim Nasuha Bakhtiar, M. Taher Darnis, Deny Susanti RS Pharmacy and materia medica Infectious diseases constitute an arising number of annual deaths recorded worldwide. The world is currently experiencing challenges of increased resistance development against available antimicrobial drugs. Therefore, the search for new antimicrobial drug is urgently needed to reduce the burden of disease globally. Traditional plants have been a prominent source in drug discovery. Artocarpuslanceifolius is used in this study as it is known to have many therapeutic values. Thus, the aim of this study is to screen for antimicrobial activity in the leaves extracts of A.lanceifolius against selected microorganisms. Extraction is done via Soxhlet apparatus with a series of solvents, n-Hexane, ethyl acetate and methanol in sequence of increasing polarity. Antimicrobial properties are evaluated using disc diffusion and broth microdilutionmethod. The obtained results showed that only methanol and ethyl acetate extracts exhibit antimicrobial properties whereas n-Hexane possessed no antimicrobial properties. Among the tested microorganisms, only Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) were found to be susceptible towards methanol extract (Inhibition zone: 11.33 - 12.33 mm; MIC value: 50 mg/ml; MBC value: 100 mg/ml) and ethyl acetate extract (Inhibition zone: 7.67 – 11.67 mm; MIC value: 50 and 100 mg/ml for B. cereus and S. aureus, respectively; MBC value: 100 mg/ml). Meanwhile, Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Candidaalbicansand Aspergillus spp.) were found to be not sensitive towards all extracts. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/39552/2/IHCI_2014_Abstract_Book.pdf application/pdf en http://irep.iium.edu.my/39552/3/IHCI_2014_Programme_Book.pdf application/pdf en http://irep.iium.edu.my/39552/8/poster_ihci_fatim-2.pdf Mohamed Safri, Fatim Nasuha and Bakhtiar, M. Taher and Darnis, Deny Susanti (2014) Antimicrobial study of the leaves extracts of atocarpus lanceifolius. In: International Health Conference IIUM 2014, 3-4 December 2014, Kuantan. (Unpublished) http://www.iium.edu.my/ihci
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohamed Safri, Fatim Nasuha Bakhtiar, M. Taher Darnis, Deny Susanti Antimicrobial study of the leaves extracts of atocarpus lanceifolius
description	Infectious diseases constitute an arising number of annual deaths recorded worldwide. The world is currently experiencing challenges of increased resistance development against available antimicrobial drugs. Therefore, the search for new antimicrobial drug is urgently needed to reduce the burden of disease globally. Traditional plants have been a prominent source in drug discovery. Artocarpuslanceifolius is used in this study as it is known to have many therapeutic values. Thus, the aim of this study is to screen for antimicrobial activity in the leaves extracts of A.lanceifolius against selected microorganisms. Extraction is done via Soxhlet apparatus with a series of solvents, n-Hexane, ethyl acetate and methanol in sequence of increasing polarity. Antimicrobial properties are evaluated using disc diffusion and broth microdilutionmethod. The obtained results showed that only methanol and ethyl acetate extracts exhibit antimicrobial properties whereas n-Hexane possessed no antimicrobial properties. Among the tested microorganisms, only Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) were found to be susceptible towards methanol extract (Inhibition zone: 11.33 - 12.33 mm; MIC value: 50 mg/ml; MBC value: 100 mg/ml) and ethyl acetate extract (Inhibition zone: 7.67 – 11.67 mm; MIC value: 50 and 100 mg/ml for B. cereus and S. aureus, respectively; MBC value: 100 mg/ml). Meanwhile, Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Candidaalbicansand Aspergillus spp.) were found to be not sensitive towards all extracts.
format	Conference or Workshop Item
author	Mohamed Safri, Fatim Nasuha Bakhtiar, M. Taher Darnis, Deny Susanti
author_facet	Mohamed Safri, Fatim Nasuha Bakhtiar, M. Taher Darnis, Deny Susanti
author_sort	Mohamed Safri, Fatim Nasuha
title	Antimicrobial study of the leaves extracts of atocarpus lanceifolius
title_short	Antimicrobial study of the leaves extracts of atocarpus lanceifolius
title_full	Antimicrobial study of the leaves extracts of atocarpus lanceifolius
title_fullStr	Antimicrobial study of the leaves extracts of atocarpus lanceifolius
title_full_unstemmed	Antimicrobial study of the leaves extracts of atocarpus lanceifolius
title_sort	antimicrobial study of the leaves extracts of atocarpus lanceifolius
publishDate	2014
url	http://irep.iium.edu.my/39552/ http://irep.iium.edu.my/39552/ http://irep.iium.edu.my/39552/2/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39552/3/IHCI_2014_Programme_Book.pdf http://irep.iium.edu.my/39552/8/poster_ihci_fatim-2.pdf
first_indexed	2023-09-18T20:56:51Z
last_indexed	2023-09-18T20:56:51Z
_version_	1777410361177145344

Antimicrobial study of the leaves extracts of atocarpus lanceifolius

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