Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines

Natural products have been recognized and utilized by humans in management of disease, injuries and other health problems. This study was conducted to evaluate cytotoxic and anti- inflammatory activities of Garcinia xanthochymus extracts on cell lines. Roots and stem barks of plant were extracted us...

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Main Authors:	Hamidon, Hanisuhana, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/39531/ http://irep.iium.edu.my/39531/ http://irep.iium.edu.my/39531/1/IHCI_2014_Programme_Book.pdf http://irep.iium.edu.my/39531/2/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39531/3/IHCI_poster_-_Anis-2.pptx http://irep.iium.edu.my/39531/8/IHCI_poster_-_Anis-2.pdf

id	iium-39531
recordtype	eprints
spelling	iium-395312015-01-06T10:34:41Z http://irep.iium.edu.my/39531/ Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines Hamidon, Hanisuhana Bakhtiar, M. Taher RS Pharmacy and materia medica Natural products have been recognized and utilized by humans in management of disease, injuries and other health problems. This study was conducted to evaluate cytotoxic and anti- inflammatory activities of Garcinia xanthochymus extracts on cell lines. Roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. Cell viability study of extracts against cell line was first done using MTT assay. Then, chosen safe concentration was used in the nitric oxide production study in LPS-stimulated cells that based on Griess reagent reaction. The result of cytotoxicity study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. As conclusion, these finding indicated that G. xanthochymus extracts may become interesting candidate for treatment of cancer and inflammation. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/39531/1/IHCI_2014_Programme_Book.pdf application/pdf en http://irep.iium.edu.my/39531/2/IHCI_2014_Abstract_Book.pdf application/pdf en http://irep.iium.edu.my/39531/3/IHCI_poster_-_Anis-2.pptx application/pdf en http://irep.iium.edu.my/39531/8/IHCI_poster_-_Anis-2.pdf Hamidon, Hanisuhana and Bakhtiar, M. Taher (2014) Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines. In: International Health Conference IIUM 2014, 3rd - 4th December 2014, Kuantan, Pahang. (Unpublished) http://www.iium.edu.my/ihci
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Hamidon, Hanisuhana Bakhtiar, M. Taher Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
description	Natural products have been recognized and utilized by humans in management of disease, injuries and other health problems. This study was conducted to evaluate cytotoxic and anti- inflammatory activities of Garcinia xanthochymus extracts on cell lines. Roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. Cell viability study of extracts against cell line was first done using MTT assay. Then, chosen safe concentration was used in the nitric oxide production study in LPS-stimulated cells that based on Griess reagent reaction. The result of cytotoxicity study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. As conclusion, these finding indicated that G. xanthochymus extracts may become interesting candidate for treatment of cancer and inflammation.
format	Conference or Workshop Item
author	Hamidon, Hanisuhana Bakhtiar, M. Taher
author_facet	Hamidon, Hanisuhana Bakhtiar, M. Taher
author_sort	Hamidon, Hanisuhana
title	Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
title_short	Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
title_full	Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
title_fullStr	Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
title_full_unstemmed	Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
title_sort	cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
publishDate	2014
url	http://irep.iium.edu.my/39531/ http://irep.iium.edu.my/39531/ http://irep.iium.edu.my/39531/1/IHCI_2014_Programme_Book.pdf http://irep.iium.edu.my/39531/2/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39531/3/IHCI_poster_-_Anis-2.pptx http://irep.iium.edu.my/39531/8/IHCI_poster_-_Anis-2.pdf
first_indexed	2023-09-18T20:56:48Z
last_indexed	2023-09-18T20:56:48Z
_version_	1777410358392127488

Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines

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