Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?

The prevalence of diabetes mellitus has reached epidemic proportion in Malaysia and worldwide. Scientific studies have shown that herbal plant Piper sarmentosum exhibits an antidiabetic property. Despite the extensive usage and studies of this herb as alternative medicine, there is paucity of the li...

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Main Authors:	Mohd Zainudi, Maizura, Zakaria, Zaiton, Megat Mohd Nordin, Nor Anita, Othman, Faizah
Format:	Article
Language:	English
Published:	Hindawi Publishing Corporation 2013
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/39527/ http://irep.iium.edu.my/39527/ http://irep.iium.edu.my/39527/ http://irep.iium.edu.my/39527/1/705950_MAIZURA.pdf

id	iium-39527
recordtype	eprints
spelling	iium-395272015-04-09T08:45:24Z http://irep.iium.edu.my/39527/ Does oral ingestion of piper sarmentosum cause toxicity in experimental animals? Mohd Zainudi, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita Othman, Faizah R Medicine (General) The prevalence of diabetes mellitus has reached epidemic proportion in Malaysia and worldwide. Scientific studies have shown that herbal plant Piper sarmentosum exhibits an antidiabetic property. Despite the extensive usage and studies of this herb as alternative medicine, there is paucity of the literature on the safety information of this plant. Thus, the present study aimed to observe the subacute toxic effects of Piper sarmentosum aqueous extract (PSAE) on the haematological profile, liver, and kidney in rats. The extract was administered by oral gavage to 6 male and female Sprague Dawley rats in daily dose of 50 mg/kg, 300 mg/kg, and 2000 mg/kg for 28 consecutive days. The control group received normal saline. General behavior of the rats, adverse effects, and mortality were observed for 28 days. The haematological and biochemical parameters were determined at baseline and after the treatment. PSAE did not show abnormality on the body weight and gross observation of internal organs. The haematological, biochemical and histopathological profiles showed minimal changes and variation within normal clinical range except for significant increase in serum potassium level that suggests the need of regular monitoring. Nevertheless, these findings suggested that PSAE up to 2000 mg/kg/day did not show subacute toxicity in Sprague Dawley rats. Hindawi Publishing Corporation 2013-06-24 Article PeerReviewed application/pdf en cc_by http://irep.iium.edu.my/39527/1/705950_MAIZURA.pdf Mohd Zainudi, Maizura and Zakaria, Zaiton and Megat Mohd Nordin, Nor Anita and Othman, Faizah (2013) Does oral ingestion of piper sarmentosum cause toxicity in experimental animals? Evidence-Based Complementary and Alternative Medicine, 2013. pp. 1-9. ISSN 1741-427X http://www.hindawi.com/journals/ecam/2013/705950/ http://dx.doi.org/10.1155/2013/705950
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohd Zainudi, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita Othman, Faizah Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?
description	The prevalence of diabetes mellitus has reached epidemic proportion in Malaysia and worldwide. Scientific studies have shown that herbal plant Piper sarmentosum exhibits an antidiabetic property. Despite the extensive usage and studies of this herb as alternative medicine, there is paucity of the literature on the safety information of this plant. Thus, the present study aimed to observe the subacute toxic effects of Piper sarmentosum aqueous extract (PSAE) on the haematological profile, liver, and kidney in rats. The extract was administered by oral gavage to 6 male and female Sprague Dawley rats in daily dose of 50 mg/kg, 300 mg/kg, and 2000 mg/kg for 28 consecutive days. The control group received normal saline. General behavior of the rats, adverse effects, and mortality were observed for 28 days. The haematological and biochemical parameters were determined at baseline and after the treatment. PSAE did not show abnormality on the body weight and gross observation of internal organs. The haematological, biochemical and histopathological profiles showed minimal changes and variation within normal clinical range except for significant increase in serum potassium level that suggests the need of regular monitoring. Nevertheless, these findings suggested that PSAE up to 2000 mg/kg/day did not show subacute toxicity in Sprague Dawley rats.
format	Article
author	Mohd Zainudi, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita Othman, Faizah
author_facet	Mohd Zainudi, Maizura Zakaria, Zaiton Megat Mohd Nordin, Nor Anita Othman, Faizah
author_sort	Mohd Zainudi, Maizura
title	Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?
title_short	Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?
title_full	Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?
title_fullStr	Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?
title_full_unstemmed	Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?
title_sort	does oral ingestion of piper sarmentosum cause toxicity in experimental animals?
publisher	Hindawi Publishing Corporation
publishDate	2013
url	http://irep.iium.edu.my/39527/ http://irep.iium.edu.my/39527/ http://irep.iium.edu.my/39527/ http://irep.iium.edu.my/39527/1/705950_MAIZURA.pdf
first_indexed	2023-09-18T20:56:48Z
last_indexed	2023-09-18T20:56:48Z
_version_	1777410357961162752

Does oral ingestion of piper sarmentosum cause toxicity in experimental animals?

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