The effect of eurycoma longifolia jack root extract on serum lipids of rats

Eurycoma Longifolia jack (E.L) has many useful biological activities and there is continuous research to find new effects of this plant. Objectives: to investigate the effect of E.L. extract on serum lipids of rats. Methodology: 40 mature albino Wistar rats were used. Baseline blood samples were ana...

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Main Authors:	Faisal, Ghasak Ghazi, Mustafa Al-Ahmad, Basma Ezzat, Mustafa, Nazih Shaban, Najmuldeen, Ghazi Faisal, Althunibat, Osama Yousef
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2014
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/38903/ http://irep.iium.edu.my/38903/ http://irep.iium.edu.my/38903/1/ICNP_2014_poster.pdf http://irep.iium.edu.my/38903/4/ICNP_2014.pdf http://irep.iium.edu.my/38903/5/conference_book.pdf http://irep.iium.edu.my/38903/8/scan0002.pdf

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spelling	iium-389032015-01-08T11:21:07Z http://irep.iium.edu.my/38903/ The effect of eurycoma longifolia jack root extract on serum lipids of rats Faisal, Ghasak Ghazi Mustafa Al-Ahmad, Basma Ezzat Mustafa, Nazih Shaban Najmuldeen, Ghazi Faisal Althunibat, Osama Yousef R Medicine (General) RB Pathology Eurycoma Longifolia jack (E.L) has many useful biological activities and there is continuous research to find new effects of this plant. Objectives: to investigate the effect of E.L. extract on serum lipids of rats. Methodology: 40 mature albino Wistar rats were used. Baseline blood samples were analyzed for serum lipids; cholesterol(chol) ,High density lipoprotein (HDL) and Low density Lipoprotein (LDL). The rats were then kept for 4 weeks on high fat diet. After that period , serum lipid analysis was done again. Then the rats were divided into 2 groups (A,B) and kept on the same high fat diet and additionally received twice daily treatment of E.L. root extract with a dose of 5and 10mg/Kg for group A and B respectively for 4 weeks.Lipid analysis was done again. Results: There was a statistically significant rise in the cholesterol level from the baseline of 136 to 192mg/dl after feeding with high fat diet. However, after treatment with E.L. extract, Both group A and B showed a significant decrease in the cholesterol level 142,139 mg/dl respectively. Regarding LDL and HDL, group A showed a more favorable outcome because in group B there was a sharp drop in the HDL and a rise in LDL level which makes the LDL/HDL ratio increase well above the recommended safety limits. Conclusion: E.L. root extract may be used for lowering of serum cholesterol. However, the dose should be adjusted to prevent unwanted changes in HDL and LDL levels. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/38903/1/ICNP_2014_poster.pdf application/pdf en http://irep.iium.edu.my/38903/4/ICNP_2014.pdf application/pdf en http://irep.iium.edu.my/38903/5/conference_book.pdf application/pdf en http://irep.iium.edu.my/38903/8/scan0002.pdf Faisal, Ghasak Ghazi and Mustafa Al-Ahmad, Basma Ezzat and Mustafa, Nazih Shaban and Najmuldeen, Ghazi Faisal and Althunibat, Osama Yousef (2014) The effect of eurycoma longifolia jack root extract on serum lipids of rats. In: International Conference on Natural Products 2014, 18-19 Mar 2014, Putrajaya. http://www.ukm.my/icnp2014/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Faisal, Ghasak Ghazi Mustafa Al-Ahmad, Basma Ezzat Mustafa, Nazih Shaban Najmuldeen, Ghazi Faisal Althunibat, Osama Yousef The effect of eurycoma longifolia jack root extract on serum lipids of rats
description	Eurycoma Longifolia jack (E.L) has many useful biological activities and there is continuous research to find new effects of this plant. Objectives: to investigate the effect of E.L. extract on serum lipids of rats. Methodology: 40 mature albino Wistar rats were used. Baseline blood samples were analyzed for serum lipids; cholesterol(chol) ,High density lipoprotein (HDL) and Low density Lipoprotein (LDL). The rats were then kept for 4 weeks on high fat diet. After that period , serum lipid analysis was done again. Then the rats were divided into 2 groups (A,B) and kept on the same high fat diet and additionally received twice daily treatment of E.L. root extract with a dose of 5and 10mg/Kg for group A and B respectively for 4 weeks.Lipid analysis was done again. Results: There was a statistically significant rise in the cholesterol level from the baseline of 136 to 192mg/dl after feeding with high fat diet. However, after treatment with E.L. extract, Both group A and B showed a significant decrease in the cholesterol level 142,139 mg/dl respectively. Regarding LDL and HDL, group A showed a more favorable outcome because in group B there was a sharp drop in the HDL and a rise in LDL level which makes the LDL/HDL ratio increase well above the recommended safety limits. Conclusion: E.L. root extract may be used for lowering of serum cholesterol. However, the dose should be adjusted to prevent unwanted changes in HDL and LDL levels.
format	Conference or Workshop Item
author	Faisal, Ghasak Ghazi Mustafa Al-Ahmad, Basma Ezzat Mustafa, Nazih Shaban Najmuldeen, Ghazi Faisal Althunibat, Osama Yousef
author_facet	Faisal, Ghasak Ghazi Mustafa Al-Ahmad, Basma Ezzat Mustafa, Nazih Shaban Najmuldeen, Ghazi Faisal Althunibat, Osama Yousef
author_sort	Faisal, Ghasak Ghazi
title	The effect of eurycoma longifolia jack root extract on serum lipids of rats
title_short	The effect of eurycoma longifolia jack root extract on serum lipids of rats
title_full	The effect of eurycoma longifolia jack root extract on serum lipids of rats
title_fullStr	The effect of eurycoma longifolia jack root extract on serum lipids of rats
title_full_unstemmed	The effect of eurycoma longifolia jack root extract on serum lipids of rats
title_sort	effect of eurycoma longifolia jack root extract on serum lipids of rats
publishDate	2014
url	http://irep.iium.edu.my/38903/ http://irep.iium.edu.my/38903/ http://irep.iium.edu.my/38903/1/ICNP_2014_poster.pdf http://irep.iium.edu.my/38903/4/ICNP_2014.pdf http://irep.iium.edu.my/38903/5/conference_book.pdf http://irep.iium.edu.my/38903/8/scan0002.pdf
first_indexed	2023-09-18T20:55:54Z
last_indexed	2023-09-18T20:55:54Z
_version_	1777410301404119040

The effect of eurycoma longifolia jack root extract on serum lipids of rats

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