Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice

Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice

Pain sensation is the major problem worldwide which may affect human health and lifestyle. The search for pain relieving agents continued to rise over time. Alkaloid is believed to stimulate analgesic activity via blocking transmission of pain stimuli on both central and peripheral pain. The study a...

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Main Authors: Soib, Husnul Hanani, Wan Sulaiman, Wan Mohd. Azizi, Darnis, Deny Susanti, Tg Zakaria, Tg Muhammad Faris Syafiq, Edueng, Khadijah, Bakhtiar, M. Taher
Format: Article
Language:English
Published: Malaysian Pharmaceutical Society 2014
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/38826/
http://irep.iium.edu.my/38826/
http://irep.iium.edu.my/38826/1/Malaysian_Journal_of_Pharmacy.pdf
id iium-38826
recordtype eprints
spelling iium-388262015-01-29T08:31:19Z http://irep.iium.edu.my/38826/ Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice Soib, Husnul Hanani Wan Sulaiman, Wan Mohd. Azizi Darnis, Deny Susanti Tg Zakaria, Tg Muhammad Faris Syafiq Edueng, Khadijah Bakhtiar, M. Taher RS Pharmacy and materia medica Pain sensation is the major problem worldwide which may affect human health and lifestyle. The search for pain relieving agents continued to rise over time. Alkaloid is believed to stimulate analgesic activity via blocking transmission of pain stimuli on both central and peripheral pain. The study aimed to investigate the antinociceptive effects of alkaloids rich fraction of Aidia densiflora (AD) in albino ICR mice via acetic acid-induced writhing and the hot plate tests, which was reversed by aspirin. Four groups of mice were separated and treated with alkaloids extract from AD at increasing doses of 100, 200, 500, 1000 mg/kg. In writhing test, subcutaneously administered AD extract was reported to maximally block abdominal contraction by 71.1% at 1000 mg/kg (p<0.05) as compared to lower doses. Meanwhile, the hot plate test (55°C) revealed that intraperitoneally administered AD showed that there was no significant difference between lower doses which corresponded to 100 and 200 mg/kg AD. However, higher dose of 500 and 1000 mg/kg were statistically significant (p<0.05). Therefore, the results suggested that the alkaloid extract possessed potential analgesic activities which demonstrated to act through both peripheral and central mechanisms of pain. Despite safety and effectiveness profile of the extract, the present data may serve as the basis for the rational utilization of AD in alleviating symptoms including pain. Malaysian Pharmaceutical Society 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38826/1/Malaysian_Journal_of_Pharmacy.pdf Soib, Husnul Hanani and Wan Sulaiman, Wan Mohd. Azizi and Darnis, Deny Susanti and Tg Zakaria, Tg Muhammad Faris Syafiq and Edueng, Khadijah and Bakhtiar, M. Taher (2014) Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice. Malaysian Journal of Pharmacy, 1 (11). p. 223. ISSN 1675-3666 http://www.mps.org.my
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Soib, Husnul Hanani
Wan Sulaiman, Wan Mohd. Azizi
Darnis, Deny Susanti
Tg Zakaria, Tg Muhammad Faris Syafiq
Edueng, Khadijah
Bakhtiar, M. Taher
Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice
description Pain sensation is the major problem worldwide which may affect human health and lifestyle. The search for pain relieving agents continued to rise over time. Alkaloid is believed to stimulate analgesic activity via blocking transmission of pain stimuli on both central and peripheral pain. The study aimed to investigate the antinociceptive effects of alkaloids rich fraction of Aidia densiflora (AD) in albino ICR mice via acetic acid-induced writhing and the hot plate tests, which was reversed by aspirin. Four groups of mice were separated and treated with alkaloids extract from AD at increasing doses of 100, 200, 500, 1000 mg/kg. In writhing test, subcutaneously administered AD extract was reported to maximally block abdominal contraction by 71.1% at 1000 mg/kg (p<0.05) as compared to lower doses. Meanwhile, the hot plate test (55°C) revealed that intraperitoneally administered AD showed that there was no significant difference between lower doses which corresponded to 100 and 200 mg/kg AD. However, higher dose of 500 and 1000 mg/kg were statistically significant (p<0.05). Therefore, the results suggested that the alkaloid extract possessed potential analgesic activities which demonstrated to act through both peripheral and central mechanisms of pain. Despite safety and effectiveness profile of the extract, the present data may serve as the basis for the rational utilization of AD in alleviating symptoms including pain.
format Article
author Soib, Husnul Hanani
Wan Sulaiman, Wan Mohd. Azizi
Darnis, Deny Susanti
Tg Zakaria, Tg Muhammad Faris Syafiq
Edueng, Khadijah
Bakhtiar, M. Taher
author_facet Soib, Husnul Hanani
Wan Sulaiman, Wan Mohd. Azizi
Darnis, Deny Susanti
Tg Zakaria, Tg Muhammad Faris Syafiq
Edueng, Khadijah
Bakhtiar, M. Taher
author_sort Soib, Husnul Hanani
title Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice
title_short Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice
title_full Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice
title_fullStr Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice
title_full_unstemmed Antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice
title_sort antinociceptive effects of alkaloids rich fraction of aidia densiflora in mice
publisher Malaysian Pharmaceutical Society
publishDate 2014
url http://irep.iium.edu.my/38826/
http://irep.iium.edu.my/38826/
http://irep.iium.edu.my/38826/1/Malaysian_Journal_of_Pharmacy.pdf
first_indexed 2023-09-18T20:55:47Z
last_indexed 2023-09-18T20:55:47Z
_version_ 1777410294129098752

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