Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes

Cinnamon is a common spice which is widely advocated for its efficacy controlling of hyperglycemia. However, the mechanism of action has yet to be established for the effect on the blood glucose concentration. Cinnamon was extracted with water and induced to cell line namely 3T3-L1 preadipocyte (Ame...

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Main Authors:	Azahari, Nuraniza, Khattak, Muhammad Muzaffar Ali Khan, Bakhtiar, M. Taher, Arief Ichwan, Solachuddin Jauhari
Format:	Article
Language:	English
Published:	Science and Education Publishing 2014
Subjects:	TX Home economics TX341 Nutrition. Foods and food supply
Online Access:	http://irep.iium.edu.my/38810/ http://irep.iium.edu.my/38810/ http://irep.iium.edu.my/38810/ http://irep.iium.edu.my/38810/1/Nuraniza_Paper_1.pdf

id	iium-38810
recordtype	eprints
spelling	iium-388102019-09-03T02:20:49Z http://irep.iium.edu.my/38810/ Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes Azahari, Nuraniza Khattak, Muhammad Muzaffar Ali Khan Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari TX Home economics TX341 Nutrition. Foods and food supply Cinnamon is a common spice which is widely advocated for its efficacy controlling of hyperglycemia. However, the mechanism of action has yet to be established for the effect on the blood glucose concentration. Cinnamon was extracted with water and induced to cell line namely 3T3-L1 preadipocyte (American Type cell Culture Collection). The cell proliferation, differentiation (adipogenesis) and glucose uptake activity were assessed by measuring the uptake of radio-labelled glucose. Furthermore, for comparison glucose oxidase assay was also performed by using Glucose Assay Kit (Sigma-Aldrich, Inc). The collected data was statistically analysed using SPSS version 12.0 for any possible differences. This study revealed that there was a significant (P<0.01) increase the activity/adipogenesis. This increase activity was accompanied by significant (P<0.01) increase in the glucose uptake and reduced catalytic activity of lipids (lipolysis). The finding reveals that C. Zeylanicum extract has similar effect to that of insulin activity. The present study suggests that the cinnamon enhances glucose uptakes, reduces the lipid breakdown and resembles insulin activity. Science and Education Publishing 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38810/1/Nuraniza_Paper_1.pdf Azahari, Nuraniza and Khattak, Muhammad Muzaffar Ali Khan and Bakhtiar, M. Taher and Arief Ichwan, Solachuddin Jauhari (2014) Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes. Journal of Food and Nutrition Research, 2 (11). pp. 764-769. ISSN 13368672 http://www.sciepub.com/journal/JFNR 10.12691/jfnr-2-11-1
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TX Home economics TX341 Nutrition. Foods and food supply
spellingShingle	TX Home economics TX341 Nutrition. Foods and food supply Azahari, Nuraniza Khattak, Muhammad Muzaffar Ali Khan Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes
description	Cinnamon is a common spice which is widely advocated for its efficacy controlling of hyperglycemia. However, the mechanism of action has yet to be established for the effect on the blood glucose concentration. Cinnamon was extracted with water and induced to cell line namely 3T3-L1 preadipocyte (American Type cell Culture Collection). The cell proliferation, differentiation (adipogenesis) and glucose uptake activity were assessed by measuring the uptake of radio-labelled glucose. Furthermore, for comparison glucose oxidase assay was also performed by using Glucose Assay Kit (Sigma-Aldrich, Inc). The collected data was statistically analysed using SPSS version 12.0 for any possible differences. This study revealed that there was a significant (P<0.01) increase the activity/adipogenesis. This increase activity was accompanied by significant (P<0.01) increase in the glucose uptake and reduced catalytic activity of lipids (lipolysis). The finding reveals that C. Zeylanicum extract has similar effect to that of insulin activity. The present study suggests that the cinnamon enhances glucose uptakes, reduces the lipid breakdown and resembles insulin activity.
format	Article
author	Azahari, Nuraniza Khattak, Muhammad Muzaffar Ali Khan Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari
author_facet	Azahari, Nuraniza Khattak, Muhammad Muzaffar Ali Khan Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari
author_sort	Azahari, Nuraniza
title	Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes
title_short	Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes
title_full	Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes
title_fullStr	Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes
title_full_unstemmed	Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes
title_sort	dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3t3-l1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes
publisher	Science and Education Publishing
publishDate	2014
url	http://irep.iium.edu.my/38810/ http://irep.iium.edu.my/38810/ http://irep.iium.edu.my/38810/ http://irep.iium.edu.my/38810/1/Nuraniza_Paper_1.pdf
first_indexed	2023-09-18T20:55:46Z
last_indexed	2023-09-18T20:55:46Z
_version_	1777410292927430656

Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes

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