Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines

Thymoquinone (TQ) is the main constituent of black seed (Nigella sativa, spp) essential oil which shows promising in vitro and in vivo anti-neoplastic activities in different tumor cell lines. However, to date there are only a few reports regarding the apoptotic effects of TQ on cervical cancer cell...

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Main Authors:	Arief Ichwan, Solachuddin Jauhari, Al-Ani, Imad Matloub Dally, Bilal, Hakim Gharib, Suriyah, Wastuti Hidayati, Bakhtiar, M. Taher, Ikeda, Masa-Aki
Format:	Article
Language:	English
Published:	The Chinese Physiological Society and Airiti Press Inc 2014
Subjects:	RB Pathology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/38368/ http://irep.iium.edu.my/38368/ http://irep.iium.edu.my/38368/ http://irep.iium.edu.my/38368/4/Apoptotic_Activities_of_Thymoquinone.pdf

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recordtype	eprints
spelling	iium-383682018-06-12T02:04:09Z http://irep.iium.edu.my/38368/ Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines Arief Ichwan, Solachuddin Jauhari Al-Ani, Imad Matloub Dally Bilal, Hakim Gharib Suriyah, Wastuti Hidayati Bakhtiar, M. Taher Ikeda, Masa-Aki Bilal, Hakim Gharib RB Pathology RM300 Drugs and their action Thymoquinone (TQ) is the main constituent of black seed (Nigella sativa, spp) essential oil which shows promising in vitro and in vivo anti-neoplastic activities in different tumor cell lines. However, to date there are only a few reports regarding the apoptotic effects of TQ on cervical cancer cells. Here, we report that TQ stimulated distinct apoptotic pathways in two human cervical cell lines, Siha and C33A. TQ markedly induced apoptosis as demonstrated by cell cycle analysis in both cell lines. More- over, quantitative PCR revealed that TQ induced apoptosis in Siha cells through p53-dependent pathway as shown by elevated level of p53-mediated apoptosis target genes, whereas apoptosis in C33A cells was mainly associated with the activation of caspase-3. These results support previous findings on TQ as a potential therapeutic agent for human cervical cancer. The Chinese Physiological Society and Airiti Press Inc 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38368/4/Apoptotic_Activities_of_Thymoquinone.pdf Arief Ichwan, Solachuddin Jauhari and Al-Ani, Imad Matloub Dally and Bilal, Hakim Gharib and Suriyah, Wastuti Hidayati and Bakhtiar, M. Taher and Ikeda, Masa-Aki and Bilal, Hakim Gharib (2014) Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines. Chinese Journal of Physiology , 57 (5). 249 -255. ISSN 0304-4920 http://www.cps.org.tw/index.php?id=259 10.4077/CJP.2014.BAB190
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology RM300 Drugs and their action
spellingShingle	RB Pathology RM300 Drugs and their action Arief Ichwan, Solachuddin Jauhari Al-Ani, Imad Matloub Dally Bilal, Hakim Gharib Suriyah, Wastuti Hidayati Bakhtiar, M. Taher Ikeda, Masa-Aki Bilal, Hakim Gharib Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
description	Thymoquinone (TQ) is the main constituent of black seed (Nigella sativa, spp) essential oil which shows promising in vitro and in vivo anti-neoplastic activities in different tumor cell lines. However, to date there are only a few reports regarding the apoptotic effects of TQ on cervical cancer cells. Here, we report that TQ stimulated distinct apoptotic pathways in two human cervical cell lines, Siha and C33A. TQ markedly induced apoptosis as demonstrated by cell cycle analysis in both cell lines. More- over, quantitative PCR revealed that TQ induced apoptosis in Siha cells through p53-dependent pathway as shown by elevated level of p53-mediated apoptosis target genes, whereas apoptosis in C33A cells was mainly associated with the activation of caspase-3. These results support previous findings on TQ as a potential therapeutic agent for human cervical cancer.
format	Article
author	Arief Ichwan, Solachuddin Jauhari Al-Ani, Imad Matloub Dally Bilal, Hakim Gharib Suriyah, Wastuti Hidayati Bakhtiar, M. Taher Ikeda, Masa-Aki Bilal, Hakim Gharib
author_facet	Arief Ichwan, Solachuddin Jauhari Al-Ani, Imad Matloub Dally Bilal, Hakim Gharib Suriyah, Wastuti Hidayati Bakhtiar, M. Taher Ikeda, Masa-Aki Bilal, Hakim Gharib
author_sort	Arief Ichwan, Solachuddin Jauhari
title	Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
title_short	Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
title_full	Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
title_fullStr	Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
title_full_unstemmed	Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
title_sort	apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
publisher	The Chinese Physiological Society and Airiti Press Inc
publishDate	2014
url	http://irep.iium.edu.my/38368/ http://irep.iium.edu.my/38368/ http://irep.iium.edu.my/38368/ http://irep.iium.edu.my/38368/4/Apoptotic_Activities_of_Thymoquinone.pdf
first_indexed	2023-09-18T20:55:07Z
last_indexed	2023-09-18T20:55:07Z
_version_	1777410252205981696

Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines

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